DNA Nanosensors for Metal Ion Cancer Biomarkers

用于金属离子癌症生物标志物的 DNA 纳米传感器

• 批准号: 2878134
• 金额: --
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2878134
• 关键词: DNA; Nanosensors; Metal; Ion; Cancer

Cancer is a major cause of death with an estimated economic impact of £7.6bn per year in the UK alone. The earlier cancers are diagnosed the more successful therapies tend to be. We are developing diagnostic solutions for cancer based on programmable DNA nanodevices that are able to detect, amplify and report cancer markers in patient blood. This project will develop DNA nanodevices that detect raised concentrations of metal ions - a possible indicator for cancer onset and progression. This will be achieved through a combination of experimental and computational methods.

癌症是死亡的主要原因，仅在英国，每年的经济影响估计为76亿英镑。癌症诊断越早，治疗越成功。我们正在开发基于可编程DNA纳米器件的癌症诊断解决方案，这些器件能够检测、扩增和报告患者血液中的癌症标志物。该项目将开发检测金属离子浓度升高的DNA纳米器件-这是癌症发生和发展的可能指标。这将通过实验和计算方法相结合来实现。