CORE--Hazard Identification

危险识别核心的目标是提供毒物学和分析服务 这将被我们几乎所有的生物医学和环境科学研究所利用 项目。这个核心提供了许多调查人员需要的服务，其中一些 调查人员需要，但在技术上没有准备好执行任务。这样做的具体目的是 核心是在两个领域提供研究支持：生物响应和金属分析。这个 生物反应部分将包括生态毒性(细菌和水蚤)、哺乳动物 细胞毒性(HepG2细胞)和遗传毒性(Ames)检测。水蚤的生态毒性分析 将在与达特茅斯SBRP的财团协议中执行。金属分析 部分将使用电感耦合等离子体质谱仪分析总金属含量，并使用高效液相-电感耦合等离子体质谱分析 金属的化学物种分析。将分析多种金属，但大多数金属 将对砷及其化学形态(如代谢物)进行分析。论危险因素识别 CORE有效地为我们的SBRP提供通用分析(生物或金属分析) 因此，研究人员可以将更多的SBRP资金用于个别研究项目，并对分析进行统一的质量控制。

The objective of the Hazard Identification Core is to provide toxicological and analytical services that will be utilized by virtually all of our Biomedical and Environmental Sciences Research Projects. This Core provides a number of services that many investigators require and that some investigators need, but are not technologically equipped to perform. The Specific Aims of this Core are to provide research support in two areas: Biological Response and Metal Analysis. The Biological Response section will include ecotoxicity (bacterial and daphnia), mammalian cytotoxicity (HepG2 cells), and genotoxicity (Ames) assays. The daphnia - ecotoxicity analyses will be performed in a consortium agreement with the Dartmouth SBRP. The Metal Analyses section will use ICP-Mass Spectrometer analysis for total metal content and HPLC-ICP-MS for analysis of chemical species of metal. Multiple metals will be analyzed but the majority of the analyses will be for arsenic and its chemical species (e.g. metabolites). The Hazard Identification Core efficiently provides common analyses (biological or metal analyses) to our SBRP investigators thus allowing for more SBRP funds to be directed to the individual research projects as well as uniform quality control of the analyses.