DATA MANAGEMENT AND BIOSTATISTICS

数据管理和生物统计学

• 批准号: 7063279
• 负责人: PATRICK JOHN FOX
• 金额: $ 12.77万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7063279
• 关键词: Alzheimer' s disease; biomedical facility; clinical research; data collection; data management; dementia; human data; information dissemination; information systems; neurogenetics; neuroimaging; neuropsychology; statistical service /center

The Data Management and Biostatistics core will provide high quality data management services and statistical consulting to the University of California at San Francisco (UCSF) Alzheimer's Disease Research Center (ADRC) research projects and cores. The core will build upon the ongoing partnership between UCSF's Institute of Health and Aging (IHA) and the UCSF Memory and Aging Center (MAC). The partnership between the Memory and Aging Center (MAC) and the Institute of Health and Aging (IHA) combines over seventeen years of IHA data management expertise with a comprehensive MAC data management program, providing a strong foundation to support the goals of the UCSF ADRC to capture a broad range of neurobehavioral, genetic, neuroimaging, neuropathology and molecular biology data on a large cohort of AD and non-AD dementia patients. The strength of the UCSF ADRC data management system will be the ability to integrate and share information between all cores, projects and clinic/lab(s), greatly facilitating the progress of the research studies. In addition, the data management processes that will be implemented will ensure a timely and accurate dataset submission to the National Alzheimer's Coordinating Center (NACC), as well as the sharing of data among other external researchers. Biostatistical consultation on the design of studies and the analysis of data will be offered across all UCSF ADRC cores and projects. This consultation will produce effective, valid analyses of project data that address the research questions of interest. The specific aims of the core include (1) maintaining a centralized UCSF ADRC clinical and research database, ensuring the integrity, availability, and confidentiality of all UCSF ADRC core and project data; (2) developing and maintaining a comprehensive data quality assurance program to ensure the identification and resolution of data errors across the USCF ADRC projects and cores; (3) develop and maintaining appropriate data management processes to ensure the timely and accurate submission of all datasets requested by the NACC; and (4) providing statistical consultation on research design and data analysis to all UCSF ADRC cores and projects.

数据管理和生物统计学核心将为加利福尼亚大学旧金山大学（UCSF）阿尔茨海默氏病研究中心（ADRC）研究项目和核心提供高质量的数据管理服务和统计咨询。核心将建立在UCSF卫生与老化研究所（IHA）与UCSF内存与老化中心（MAC）之间的持续合作伙伴关系的基础上。记忆与衰老中心（MAC）与健康与衰老研究所之间的合作伙伴关系在17年以来，IHA数据管理专业知识与全面的MAC数据管理计划相结合，为UCSF ADRC的目标提供了强大的基础，以支持UCSF ADRC的目标，以捕获广泛的神经性，遗传，神经性数据，神经疗法，神经疗法，神经疗法和分子 - 分子学和分子 - 分子学和分子 - 痴呆症患者。 UCSF ADRC数据管理系统的强度将是在所有核心，项目和诊所/实验室之间整合和共享信息的能力，从而极大地促进了研究的进度。此外，将要实施的数据管理流程将确保向国家阿尔茨海默氏症协调中心（NACC）以及其他外部研究人员共享数据的数据集提交。关于研究设计和数据分析的生物统计学咨询将在所有UCSF ADRC核心和项目中提供。这项咨询将对解决感兴趣的研究问题的项目数据进行有效的有效分析。 核心的具体目的包括（1）维护集中的UCSF ADRC临床和研究数据库，以确保所有UCSF ADRC核心和项目数据的完整性，可用性和机密性； （2）制定和维护一项全面的数据质量保证计划，以确保在USCF ADRC项目和核心识别和解决数据错误； （3）开发和维护适当的数据管理流程，以确保NACC要求的所有数据集及时，准确地提交； （4）向所有UCSF ADRC核心和项目提供有关研究设计和数据分析的统计咨询。