CORE--DATA MANAGEMENT AND BIOSTATISTICS

核心——数据管理和生物统计学

• 批准号: 6481087
• 负责人: PATRICK JOHN FOX
• 金额: $ 8.96万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6481087
• 关键词: Alzheimer's disease; aging; biomedical facility; data management; dementia; human middle age (35-64); human old age (65+); human subject; information systems; neural degeneration; progressive supranuclear palsy; statistics /biometry

DESCRIPTION (provided by applicant): The purpose of the Data Management and Biostatistical Core is to provide database and statistical support for the entire PPG. The specific aims are to manage the multi-disciplinary database incorporating data from the Clinical and Administrative Core, the Pathology Core, and the four individual Projects; and provide statistical consultation to all PPG investigators. The UCSF Institute for Health and Aging (IHA), in partnership with the UCSF Department of Epidemiology and Biostatistics, will serve as the Data Management and Biostatistics Core for the proposed project. In this capacity, the data management and analysis team will design, develop and implement a data management system that will securely maintain all data that are collected from the Cores and Projects. Development of standardized data collection and management procedure will be accomplished. All instrument protocols will be maintained in a Manual of Procedures. In addition to instrument protocols, the Manual will include protocols for: 1) sample recruitment; 2) data collection; 3) submission of data to the centralized database, and 4) administrative issues. This core will create and manage a single dataset that integrates all the error-checked, standardized data from each site and makes it available to the research teams via an "intranet" site. Data security will be addressed at multiple levels. The Biostatistics Core will address the statistical issues that arise in all the Projects. Specific statistical topics (tasks) will vary by Project, but concerns related to data reduction, classification and reliability studies are common to many of the Projects and will be managed through this Core.

描述（由申请人提供）：数据管理的目的 生物统计核心是为数据库和统计支持提供 整个PPG。具体目的是管理多学科数据库 结合临床和行政核心的数据，病理 核心和四个个人项目；并提供统计咨询 给所有PPG调查人员。 UCSF卫生与老化研究所（IHA）， 与UCSF流行病学和生物统计学系的合作关系，将 作为拟议项目的数据管理和生物统计学核心。 以这种能力，数据管理和分析团队将设计，开发 并实施一个数据管理系统，该系统将安全维护所有数据 从核心和项目中收集的。标准化的开发 将完成数据收集和管理程序。所有乐器 协议将在手册中维护。此外 仪器协议，手册将包括：1）样本的协议 招聘; 2）数据收集； 3）将数据提交给集中式 数据库和4）行政问题。这个核心将创建和管理 单个数据集集成了从 每个站点，并通过“ Intranet”网站向研究团队提供它。 数据安全将在多个级别上解决。生物统计学核心 将解决所有项目中出现的统计问题。具体的 统计主题（任务）将因项目而异，但与数据有关 降低，分类和可靠性研究对于许多人来说都是共同的 项目并将通过此核心进行管理。