Mechanism of Fish Oil Supplements in Prevention of Cance

鱼油补充剂预防癌症的机制

• 批准号: 7136894
• 负责人: YONG Q CHEN
• 金额: $ 100万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-21 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7136894
• 关键词: cancer prevention; chemoprevention; dietary supplements; marine animal oil; nutrition aspect of cancer; nutrition related tag; omega 3 fatty acid; prostate neoplasms

DESCRIPTION (provided by applicant): This Program Project Grant application involves a group of investigators from Wake Forest University to understand the mechanism of action for n-3 FA, particularly those found in fish oil supplements, as relate to prostate cancer. We attempt to address the following questions: How efficient is n-3 fatty acids in reducing prostate cancer incidence, progression and metastasis in a genetically defined, immune-competent animal model with orthotopic prostate cancer? Will n-3 fatty acid intake at early age, later age or life-long have different effects on prostate cancer progression? Do inhibitors of n-6 fatty acid metabolizing enzymes have similar beneficial effect for prostate cancers as fish oil? Last but not least, what is (are) the molecular mechanism(s) by which fish oil suppress prostate cancer progression? We propose a set of four integrated and complementary research projects and three cores. They are designed to tackle a complex problem from various angles, and results from each project will help to refine others. We take advantage of our strengths of in vivo and in vitro model systems. For the first time, molecular changes (mRNA and lipid) associated with fish oil diet in the prostate will be comprehensively and systematically analyzed. In addition, conventional pathway dissection approach (phosphoinositide pathway in Project I, ecosanoid pathway in Project II, platelet activating factor pathway in Project III and syndecan pathway in Project IV) will also be applied to study the mechanism of action of fish oil on prostate cancer.

描述（由申请人提供）：该计划项目赠款申请涉及一群来自Wake Forest University的研究人员，以了解N-3 FA的作用机理，尤其是在鱼油补充剂中发现的与前列腺癌有关的调查机理。我们试图解决以下问题：N-3脂肪酸在与原位前列腺癌的遗传定义的，免疫能力的动物模型中降低前列腺癌的发生，进展和转移的效率如何？ N-3脂肪酸在早期，以后的年龄或终身会对前列腺癌的进展产生不同的影响吗？ N-6脂肪酸代谢酶的抑制剂对前列腺癌具有类似的有益作用吗？ 最后但并非最不重要的一点是，鱼油抑制前列腺癌进展的分子机制是什么？ 我们建议一组四个集成和互补的研究项目和三个核心。它们旨在从各个角度解决一个复杂的问题，每个项目的结果将有助于完善其他问题。我们利用体内和体外模型系统的优势。与前列腺中的鱼油饮食相关的分子变化（mRNA和脂质）将首次进行全面和系统的分析。此外，传统的途径解剖方法（项目I中的磷酸肌醇途径，项目II项目II，项目III的血小板激活因子途径和项目IV中的Syndecan途径）也将用于研究鱼油对前列腺癌的作用机理。