Optical Imaging of Tactile Information in SI Cortex

SI 皮层触觉信息的光学成像

• 批准号: 7266913
• 负责人: ANNA W. ROE
• 金额: $ 34万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7266913
• 关键词: Address; Anesthesia procedures; Animals; Architecture; Area; Behavior; Behavioral; Cebidae; Cells; Cercopithecidae; Complex; Condition; Digit structure; Distal; Electrodes; Epithelium; Esthesia; Exhibits; Fingers; Illusions; Image; Investigation; Maps; Masks; Methods; Modality; Numbers; Pattern; Penetration; Pentothal; Process; Property; Psychophysiology; Purpose; Relative (related person); Research Personnel; Saimiri; Sensory; Skin; Somatosensory Cortex; Standards of Weights and Measures; Stimulus; System; Tactile; Testing; Visual; Visual Cortex; Work; alertness; awake; base; driving behavior; expectation; optical imaging; preference; pressure; programs; receptive field; relating to nervous system; response; segregation; somatosensory; spatial integration; vibration

DESCRIPTION (provided by applicant): This proposal aims to study the stability of cortical representation by examining cortical maps under different states of anesthesia and alertness (pentothal and isofluane anesthesia, and awake state). Previous studies have hypothesized that different parts of single thalamocortical arbors have different degrees of dominance in Area 3b and that the effects of these secondary arbor inputs may be masked under some conditions and revealed under others. Using optical imaging and electrophysiological methods, we will probe this hypothesis by examining three aspects of finger pad representation in Area 3b and Area 1 of the squirrel monkey: topography, vibrotactile information (pressure SA, flutter RA, and vibration PC), and spatial integration (two digit). We will examine whether digit representation can, in contrast to the standard somatotopic maps, take on non-topographic organizations that are characterized by hotspots and secondary activation zones. We will examine whether SA, RA, and PC inputs can map in both overlapping and segregated manners in the superficial layers. To examine spatial integration in Area 3b and 1, we will examine whether mapping with simultaneous two-finger stimulation paradigm will result in an apparent shift in topography, and whether such a shift is more pronounced in Area 1 and more pronounced in the awake state. These examinations of alternative and shifting topographies are likely to modify the definition of topographic organization in SI and what shifting topographies are likely to modify the definition of topographic organization in SI and what topographic organization is used for in the awake animal. Furthermore, these studies may reveal that the establishment of topography is area-specific and is based on a stimulus-driven or behavior-driven integration of features rather than a simple representation of the sensory epithelium.

描述（由申请人提供）：本提案旨在通过检查不同麻醉和警觉状态（喷妥钠和异氟烷麻醉以及清醒状态）下的皮质图来研究皮质表征的稳定性。先前的研究假设，单个丘脑皮质乔木的不同部分在 3b 区具有不同程度的优势，并且这些次要乔木输入的影响可能在某些条件下被掩盖，而在其他条件下被揭示。我们将使用光学成像和电生理学方法，通过检查松鼠猴 3b 区和 1 区指垫表征的三个方面来探讨这一假设：地形、振动触觉信息（压力 SA、颤动 RA 和振动 PC）和空间积分（两位数字）。我们将研究与标准体位图相比，数字表示是否可以呈现以热点和次级激活区为特征的非地形组织。我们将检查 SA、RA 和 PC 输入是否可以在表层以重叠和隔离的方式映射。为了检查区域 3b 和 1 中的空间整合，我们将检查同时两指刺激范式的映射是否会导致地形的明显变化，以及这种变化是否在区域 1 中更明显并且在清醒状态下更明显。这些对替代和移动拓扑的检查可能会修改 SI 中拓扑组织的定义，以及哪些移动拓扑可能会修改 SI 中拓扑组织的定义以及拓扑组织在清醒动物中的用途。此外，这些研究可能揭示，地形的建立是区域特异性的，并且基于刺激驱动或行为驱动的特征整合，而不是感觉上皮的简单表示。