Functional mapping of cortical networks in primates with laser stimulation

激光刺激灵长类动物皮质网络的功能图谱

• 批准号: 8302537
• 负责人: ANNA W. ROE
• 金额: $ 22.39万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8302537
• 关键词: Animals; Area; Behavior; Behavioral; Brain; Brain Diseases; Cerebral cortex; Clinical Treatment; Development; Electric Stimulation; Electrodes; Electrophysiology (science); Engineering; Environment; Functional Magnetic Resonance Imaging; Funding Mechanisms; Future; Goals; Human; Image; Institutes; Knowledge; Lasers; Lead; Link; Local Area Networks; Macaca; Maps; Methodology; Methods; Monkeys; Network-based; Neurologic; Neurosciences; Pattern; Peripheral Nervous System; Physiologic pulse; Primates; Psychology; Relative (related person); Resolution; Scientist; System; Technology; Training; Writing; awake; base; behavior influence; high risk; mental state; multidisciplinary; neural circuit; neural stimulation; neuropsychiatry; new technology; nonhuman primate; novel; novel strategies; optical imaging; response; tool

DESCRIPTION (provided by applicant): The goal of this proposal is to achieve a method to map circuits in the brain using near infrared laser stimulation in the FMRI scanner. By using the laser to focally target 100-500um sized building blocks of cortical function (cortical functional domains), we can selectively activate networks that are functionally linked to the targeted domains. Such a capability will allow us to map non-invasively, without the introduction of electrodes into the brain, functional circuits in the cerebral cortex of the primate. Both local an global connectivity patterns will be examined with fMRI, optical imaging, and electrophysiological methods. Such capability will give us a circuit diagram of how basic cortical building blocks produce specific brain functions in behavior and, in turn, will lead to development of methodologies relevant for neurological, neuropsychiatric, and neuroprosthetic applications. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to achieve a method to map circuits in the brain using near infrared laser stimulation in the FMRI scanner. Said capability wil allow us to map circuits of small 100-500um sized building blocks (functional domains) in the cerebral cortex of the primate without the introduction of electrodes into the brain, and provide a circuit diagram of how basic cortical building blocks produce specific brain functions. This knowledge will be relevant for human neurological, neuropsychiatric, and neuroprosthetic applications, which in turn, will lead to development of methodologies that target these building blocks.

描述（由申请人提供）：本提案的目标是实现一种在FMRI扫描仪中使用近红外激光刺激来绘制大脑电路的方法。通过使用激光聚焦100-500um大小的皮质功能构建块（皮质功能域），我们可以选择性地激活与目标域功能连接的网络。这种能力将使我们能够在不将电极引入大脑的情况下，非侵入性地绘制灵长类动物大脑皮层的功能电路。局部和全局连接模式将通过功能磁共振成像、光学成像和电生理方法进行检查。这种能力将为我们提供一个基本的皮层结构模块如何在行为中产生特定的大脑功能的电路图，反过来，将导致发展