Functional mapping of cortical networks in primates with laser stimulation

描述（由申请人提供）：本提案的目标是实现一种在功能磁共振成像扫描仪中使用近红外激光刺激绘制大脑回路的方法。通过使用激光聚焦靶向100- 500 μ m大小的皮质功能构建块（皮质功能域），我们可以选择性地激活与靶向域功能相关的网络。这种能力将使我们能够非侵入性地绘制灵长类动物大脑皮层中的功能电路，而无需将电极引入大脑。局部和全局的连接模式将与功能磁共振成像，光学成像和电生理方法进行检查。这样的能力将给我们一个基本的皮层构建模块如何在行为中产生特定的大脑功能的电路图，反过来，将导致发展 与神经病学、神经精神病学和神经假体应用相关的方法学。

DESCRIPTION (provided by applicant): The goal of this proposal is to achieve a method to map circuits in the brain using near infrared laser stimulation in the FMRI scanner. By using the laser to focally target 100-500um sized building blocks of cortical function (cortical functional domains), we can selectively activate networks that are functionally linked to the targeted domains. Such a capability will allow us to map non-invasively, without the introduction of electrodes into the brain, functional circuits in the cerebral cortex of the primate. Both local an global connectivity patterns will be examined with fMRI, optical imaging, and electrophysiological methods. Such capability will give us a circuit diagram of how basic cortical building blocks produce specific brain functions in behavior and, in turn, will lead to development of methodologies relevant for neurological, neuropsychiatric, and neuroprosthetic applications.