IMAGE GUIDED BRAIN TUMOR SURGERY CORE

影像引导脑肿瘤手术核心

• 批准号: 7360386
• 负责人: ALEXANDRA J GOLBY
• 金额: $ 39.93万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7360386
• 关键词: IMAGE; GUIDED; BRAIN; TUMOR; SURGERY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This core project will develop the infrastructure required to translate basic technologic advances from other parts of the effort to the clinical treatment of patients with brain tumors. We will combine preoperative high-resolution functional MRI (fMRI), diffusion tensor imaging (DTI), and intraoperative electrophysiologic testing (ECS) in patients with brain tumors in eloquent cortex in order to accomplish the following general goals: 1) understand the relationship between the fMRI signal and neuronal activity; 2) develop methods which will improve the fidelity of preoperative functional brain mapping; 3) improve outcomes for patients with tumors in and around motor and language cortex; and 4) accurately assess the validity of this approach. These general goals will be supported by developing and implementing data collection and analysis tools and conducting experimental studies to accomplish the specific aims.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。该核心项目将开发所需的基础设施，将其他方面的基本技术进步转化为脑肿瘤患者的临床治疗。我们将结合术前高分辨率功能磁共振成像（fMRI）、弥散张量成像（DTI）和术中电生理测试（ECS）对口才皮质脑肿瘤患者进行治疗，以实现以下总体目标：1）了解fMRI信号与神经元活动之间的关系； 2）开发提高术前功能性脑图保真度的方法； 3) 改善运动和语言皮层及其周围肿瘤患者的治疗效果； 4）准确评估该方法的有效性。这些总体目标将通过开发和实施数据收集和分析工具以及进行实验研究来支持，以实现具体目标。