IMAGE GUIDED BRAIN TUMOR SURGERY CORE

影像引导脑肿瘤手术核心

• 批准号: 7563675
• 负责人: ALEXANDRA J GOLBY
• 金额: $ 46.61万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7563675
• 关键词: Brain Mapping; Brain Neoplasms; Clinical Treatment; Computer Retrieval of Information on Scientific Projects Database; Data Collection; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Image; Institution; Language; Methods; Motor; Neurons; Operative Surgical Procedures; Outcome; Patients; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Signal Transduction; Source; Testing; Translating; United States National Institutes of Health; improved; research study; tool; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This Core project will develop the infrastructure required to translate basic technologic advances from other parts of the effort to the clinical treatment of patients with brain tumors. We will combine preoperative high-resolution functional MRI (fMRI), diffusion tensor imaging (DTI), and intraoperative electrophysiologic testing (ECS) in patients with brain tumors in eloquent cortex in order to accomplish the following general goals: 1) understand the relationship between the fMRI signal and neuronal activity; 2) develop methods which will improve the fidelity of preoperative functional brain mapping; 3) improve outcomes for patients with tumors in and around motor and language cortex; and 4) accurately assess the validity of this approach. These general goals will be supported by developing and implementing data collection and analysis tools and conducting experimental studies to accomplish the specific aims.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该核心项目将开发将基本技术进步从其他部位转化为脑肿瘤患者的临床治疗所需的基础设施。我们将结合术前高分辨率功能性MRI（FMRI），扩散张量成像（DTI）和术中电生理测试（ECS）的雄性皮质中的脑肿瘤患者，以实现以下一般目标：1）了解FMRI信号和神经元的关系之间的关系：1） 2）开发方法可以提高术前功能性脑映射的保真度； 3）改善运动和语言皮层肿瘤患者的预后； 4）准确评估这种方法的有效性。这些一般目标将通过开发和实施数据收集和分析工具以及进行实验研究以实现特定目标来支持这些总体目标。