NEUROSURGERY CORE

神经外科核心

• 批准号: 7719654
• 负责人: ALEXANDRA J GOLBY
• 金额: $ 48.6万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719654
• 关键词: Brain Mapping; Brain Neoplasms; Clinical Treatment; Computer Retrieval of Information on Scientific Projects Database; Data Collection; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Institution; Language; Methods; Motor; Neurons; Outcome; Patients; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Signal Transduction; Source; Testing; Translating; United States National Institutes of Health; improved; neurosurgery; research study; tool; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This Core project will develop the infrastructure required to translate basic technologic advances from other parts of the effort to the clinical treatment of patients with brain tumors. We will combine preoperative high-resolution functional MRI (fMRI), diffusion tensor imaging (DTI), and intraoperative electrophysiologic testing (ECS) in patients with brain tumors in eloquent cortex in order to accomplish the following general goals: 1) understand the relationship between the fMRI signal and neuronal activity; 2) develop methods which will improve the fidelity of preoperative functional brain mapping; 3) improve outcomes for patients with tumors in and around motor and language cortex; and 4) accurately assess the validity of this approach. These general goals will be supported by developing and implementing data collection and analysis tools and conducting experimental studies to accomplish the specific aims.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这一核心项目将开发所需的基础设施，将基本技术进步从努力的其他部分转化为脑瘤患者的临床治疗。我们将结合术前高分辨率功能磁共振成像(FMRI)、扩散张量成像(DTI)和术中电生理测试(ECS)对功能区脑肿瘤患者进行检查，以实现以下总体目标：1)了解fMRI信号与神经元活动之间的关系；2)开发可提高术前脑功能图保真度的方法；3)改善运动和语言皮质内及周围肿瘤患者的预后；4)准确评估该方法的有效性。这些一般目标将通过开发和实施数据收集和分析工具以及进行实验研究来支持，以实现具体目标。