NEUROSURGERY CORE

神经外科核心

• 批准号: 7719654
• 负责人: ALEXANDRA J GOLBY
• 金额: $ 48.6万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719654
• 关键词: Brain Mapping; Brain Neoplasms; Clinical Treatment; Computer Retrieval of Information on Scientific Projects Database; Data Collection; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Institution; Language; Methods; Motor; Neurons; Outcome; Patients; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Signal Transduction; Source; Testing; Translating; United States National Institutes of Health; improved; neurosurgery; research study; tool; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This Core project will develop the infrastructure required to translate basic technologic advances from other parts of the effort to the clinical treatment of patients with brain tumors. We will combine preoperative high-resolution functional MRI (fMRI), diffusion tensor imaging (DTI), and intraoperative electrophysiologic testing (ECS) in patients with brain tumors in eloquent cortex in order to accomplish the following general goals: 1) understand the relationship between the fMRI signal and neuronal activity; 2) develop methods which will improve the fidelity of preoperative functional brain mapping; 3) improve outcomes for patients with tumors in and around motor and language cortex; and 4) accurately assess the validity of this approach. These general goals will be supported by developing and implementing data collection and analysis tools and conducting experimental studies to accomplish the specific aims.

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