NEUROSURGERY CORE

神经外科核心

• 批准号: 7719654
• 负责人: ALEXANDRA J GOLBY
• 金额: $ 48.6万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719654
• 关键词: Brain Mapping; Brain Neoplasms; Clinical Treatment; Computer Retrieval of Information on Scientific Projects Database; Data Collection; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Institution; Language; Methods; Motor; Neurons; Outcome; Patients; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Signal Transduction; Source; Testing; Translating; United States National Institutes of Health; improved; neurosurgery; research study; tool; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This Core project will develop the infrastructure required to translate basic technologic advances from other parts of the effort to the clinical treatment of patients with brain tumors. We will combine preoperative high-resolution functional MRI (fMRI), diffusion tensor imaging (DTI), and intraoperative electrophysiologic testing (ECS) in patients with brain tumors in eloquent cortex in order to accomplish the following general goals: 1) understand the relationship between the fMRI signal and neuronal activity; 2) develop methods which will improve the fidelity of preoperative functional brain mapping; 3) improve outcomes for patients with tumors in and around motor and language cortex; and 4) accurately assess the validity of this approach. These general goals will be supported by developing and implementing data collection and analysis tools and conducting experimental studies to accomplish the specific aims.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该核心项目将开发所需的基础设施，将其他部分的基本技术进步转化为脑肿瘤患者的临床治疗。我们将联合收割机结合术前高分辨率功能磁共振成像（fMRI）、弥散张量成像（DTI）和术中电生理测试（ECS）对功能区脑肿瘤患者进行检查，以实现以下总体目标：1）了解功能磁共振成像信号与神经元活动之间的关系; 2）开发提高术前功能脑标测保真度的方法; 3）改善运动和语言皮层及其周围肿瘤患者的预后; 4）准确评估这种方法的有效性。将通过开发和实施数据收集和分析工具以及为实现具体目标而开展实验研究来支持这些总体目标。