Resting-state fMRI for Language Mapping in Brain Tumor Patients

用于脑肿瘤患者语言映射的静息态功能磁共振成像

• 批准号: 9089962
• 负责人: ALEXANDRA J GOLBY
• 金额: $ 19.3万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9089962
• 关键词: Address; Adopted; Agreement; Area; Award; Behavioral; Behavioral Paradigm; Brain; Brain Injuries; Brain Mapping; Brain Neoplasms; Brain region; Clinical; Code; Cognitive deficits; Complex; Consensus; Data; Decision Making; Enrollment; Evaluation; Excision; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Gold; Handedness; Health; Imaging Techniques; Individual; Institution; Intracarotid; Language; Language Disorders; Language Tests; Lesion; Linguistics; Magnetic Resonance Imaging; Maps; Measures; Methods; Neurologic; Neurosurgeon; Operative Surgical Procedures; Outcome; Patients; Performance; Positioning Attribute; Protocols documentation; Quality of life; Recovery; Research; Rest; Scanning; Sensitivity and Specificity; Signal Transduction; Standardization; System; Task Performances; Techniques; Testing; Time; Translating; Translational Research; Validation; Validity and Reliability; base; blood oxygen level dependent; brain surgery; clinical application; cost effective; design; experience; image guided; improved; independent component analysis; indexing; individual patient; information processing; insight; interest; neurosurgery; prognostic value; research study; response; semantic processing; tool; tumor; validation studies

 DESCRIPTION (provided by applicant): Advances in brain mapping including functional magnetic resonance imaging (fMRI) have increased our understanding of functional brain organization. Particularly relevant for clinical applications, fMRI has proven a useful and valid method for mapping of individual brain function and is increasingly being adopted as a pre-surgical tool to guide neurosurgical decision-making. fMRI now carries a clinical billing code reflecting its utility in minimizing the use of more invasive brain mapping techniques such as the intracarotid amytal test (Wada test) for language lateralization and intra- operative electrocortical stimulation (ECS) for localization of critical brain regions. Traditional fMRI requires that the subject perform a behavioral task of interest and uses correlations between task timing and signal changes to demonstrate brain areas involved in the performance of that task. Recent studies have investigated "functional connectivity" of brain regions as a method to functionally categorize brain regions, even during resting states. The use of fMRI data acquired during rest could offer numerous advantages if it is found to be valid and reliable. Compared to task-based fMRI that requires an expert neuropsychologist to administer and score the behavioral paradigm, resting-state fMRI could be acquired by a greater range of professionals thereby making it more broadly available and cost-effective. Resting-state fMRI does not require active subject participation and may thus be particularly well-suited to patients who may have neurological deficits. Investigating functional connectivity in patients undergoing neurosurgery for brain lesions may also provide insights into the changes in brain functional organization that accompany brain injury and recovery. During the award period the research team will acquire resting-state and task-based language fMRI in 15 brain tumors patients undergoing neurosurgical evaluation and treatment. We will develop functional connectivity MRI approaches to map language function at the individual subject level. The proposed experiments will evaluate test-retest reliability and validity of resting-state fMRI for language mapping against clinical god-standard techniques in individual patients. Our hypothesis is that resting-state fMRI is reliable for language mapping, and in agreement with task-based language fMRI, Wada and ECS testing. Our goal is to improve fMRI language mapping for brain tumor surgery, and to create an easily administered test which could help standardize fMRI studies across institutions. This exploratory project will generate valuable preliminary data for larger multi-center validation of resting- state fMRI in image-guide brain tumor surgery.

 描述（通过应用程序提供）：包括功能磁共振成像（fMRI）在内的大脑映射进展已增加了我们对功能性脑组织的理解。 fMRI与临床应用特别相关，已证明是一种有用的有效方法，用于绘制个体脑功能，并越来越多地被用作指导神经外科决策的手术前工具。 FMRI现在携带临床计费代码，反映了其在最大程度地减少使用更具侵入性的脑作图技术的用途，例如语言内部化的乳突内杏仁核测试（WADA测试），用于语言侧向化和可携带内部的电内皮质刺激（EC）在关键大脑区域的定位。传统的fMRI要求主题执行感兴趣的行为任务，并使用任务时间和信号变化之间的相关性，以证明该任务执行的大脑区域。最近的研究调查了大脑区域的“功能连通性”，即即使在静止状态下，即使在静止状态下，也可以在功能上对大脑区域进行分类。如果发现有效且可靠的话，在REST期间获得的fMRI数据的使用可能会带来许多优势。与需要专家神经心理学家必须管理和评分行为范式的基于任务的功能磁共振成像相比，可以通过众多专业人员获得静止状态的fMRI，从而使其更广泛地可用且具有成本效益。静止状态的fMRI不需要积极的受试者参与，因此可能特别适合可能患有神经系统缺陷的患者。研究接受神经外科治疗的患者的功能连通性也可能提供有关涉及脑损伤和康复的大脑功能组织变化的见解。在奖励期间，研究小组将在15名接受神经外科评估和治疗的脑肿瘤患者中获取静止状态和基于任务的语言fMRI。我们将开发功能连接MRI方法，以在单个主题级别绘制语言功能。拟议的实验将评估静止状态fMRI的测试重度可靠性和有效性，用于针对个别患者的临床神标准技术的语言映射。我们的假设是，静止状态fMRI对于语言映射可靠，并且与基于任务的语言fMRI，WADA和ECS测试一致。我们的目标是改善脑肿瘤手术的功能磁共振成像映射，并创建易于管理的测试，这可以帮助标准化机构的fMRI研究。该探索性项目将生成有价值的初步数据，以在图像引物脑肿瘤手术中对静息状态fMRI进行更大的多中心验证。