OC Foundation Genetics Collaborative Conference

OC基金会遗传学合作会议

• 批准号: 7092242
• 负责人: DAVID L PAULS
• 金额: $ 12.01万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-23 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7092242
• 关键词: genetic susceptibility; meeting /conference /symposium; molecular genetics; obsessive compulsive disorder; travel

DESCRIPTION (provided by applicant): A multi-year conference grant is being proposed to support a forum for researchers to pursue collaborative studies of the molecular genetics of obsessive compulsive disorder (OCD). This application is consistent with NIMH initiatives to facilitate meetings in which researchers come together to establish mechanisms for collaborating in a manner that would facilitate the detection of genes predisposing to psychiatric disorders. At the present time, there are approximately 50 researchers who have attended the first two meetings of this group. These individuals come from 12 foreign countries and from 13 different research centers in the United States. The group has already met twice and will be meeting again in April 2004. OCD is a serious psychiatric condition that can have debilitating affects on both adults and children. The importance of genetic factors in OCD has been demonstrated by twin and family aggregation studies. Furthermore, recent molecular genetic studies have begun to provide evidence that specific genes may play a role in the manifestation of the disorder. Although these preliminary results are encouraging, several considerations suggest that fully clarifying the genetic architecture of OCD will require large samples and collaborative efforts. It is clear from ongoing studies of the genetics of schizophrenia, autism, Gilles de la Tourette's syndrome, ADHD and bipolar disorder that are consistent with statistical considerations regarding the power to locate genes for complex disorders, that samples collected by individual investigators may not be sufficiently large to provide significant evidence for genetic linkage. Furthermore, once linkage has been demonstrated, even larger sample sizes are needed to identify and characterize susceptibility genes. Thus, it is clear that coordinated collaboration is needed to share findings and pool samples. Cooperative research of this type is often difficult. With the support of the Obsessive Compulsive Foundation, a group of investigators (described above) from around the world (the OCF Genetics Collaborative) have already begun to meet to address some of these issues. The OCF has funded the first two meetings of this group. However, its funds are limited and for the most part, donors to the OCF Research Fund indicate that they want the funds that they give to support specific research projects rather than meetings. Thus, the aim of this proposal is to obtain funding that will allow this group to continue meeting to establish collaborative working groups focused on different aspects of the genetics of OCD. The hope is that data from a variety of studies being done collaboratively among members of the group will be easily combined and stored in a general data repository to be used initially by all members of the OCF Genetics Collaborative and eventually by members of the scientific community at large.

描述（由申请人提供）：正在提议一项多年期会议拨款，以支持研究人员对强迫症（OCD）分子遗传学进行合作研究的论坛。该应用程序符合 NIMH 的倡议，旨在促进研究人员聚集在一起建立合作机制，以促进检测易患精神疾病的基因。目前，大约有 50 名研究人员参加了该小组的前两次会议。这些人来自 12 来自国外和美国 13 个不同的研究中心。该小组已经召开了两次会议，并将于 2004 年 4 月再次召开会议。强迫症是一种严重的精神疾病，可能对成人和儿童造成衰弱影响。双胞胎和家庭聚集研究已经证明了遗传因素在强迫症中的重要性。此外，最近的分子遗传学研究已开始提供证据表明特定基因可能在该疾病的表现中发挥作用。 尽管这些初步结果令人鼓舞，但一些考虑因素表明，充分阐明强迫症的遗传结构将需要大量样本和协作努力。正在进行的精神分裂症、自闭症、抽动秽语综合症、多动症和双相情感障碍的遗传学研究清楚地表明，这些研究与定位复杂疾病基因的统计考虑相一致，个别研究人员收集的样本可能不够大，不足以为遗传连锁提供重要证据。此外，一旦证实了连锁，就需要更大的样本量来识别和表征易感基因。因此，很明显需要协调合作来共享研究结果和汇集样本。这种类型的合作研究通常很困难。在强迫症基金会的支持下，来自世界各地的一组研究人员（如上所述）（OCF 遗传学合作组织）已经开始开会解决其中一些问题。 OCF 资助了该小组的前两次会议。然而，其资金 OCF 研究基金的捐助者表示，他们希望所提供的资金有限，并且在大多数情况下，他们希望所提供的资金用于支持特定的研究项目而不是会议。因此，该提案的目的是获得资金，使该小组能够继续开会，建立专注于强迫症遗传学不同方面的协作工作组。希望该小组成员之间协作完成的各种研究的数据能够轻松组合并存储在通用数据存储库中，最初由 OCF 遗传学协作组织的所有成员使用，最终由整个科学界的成员使用。