OC Foundation Genetics Collaborative Conference

描述（由申请人提供）：这是一个多年会议资助的竞争性更新，该资助支持了一个研究人员进行强迫症（OCD）分子遗传学合作研究的论坛。该应用程序与NIMH倡议一致，以促进研究人员聚集在一起建立合作机制的会议，以促进检测易患精神疾病的基因。目前，大约有60名研究人员参加了该小组的会议。这些人来自13个国家和美国的38个不同的研究中心。强迫症是一种严重的精神疾病，对成人和儿童都有衰弱的影响。遗传因素在强迫症中的重要性已被双胞胎和家庭聚集研究所证实。此外，最近的分子遗传学研究已经开始提供证据表明，特定的基因可能在这种疾病的表现中发挥作用。虽然这些初步结果令人鼓舞，但一些考虑因素表明，完全澄清强迫症的遗传结构将需要大量样本和合作努力。从正在进行的精神分裂症、自闭症、抽动秽语综合征、多动症和双相情感障碍的遗传学研究中可以清楚地看出，个体研究者收集的样本可能不够大，无法为遗传连锁提供重要证据。此外，一旦连锁已经证明，甚至需要更大的样本量来识别和表征易感基因。因此，显然需要协调合作，以分享调查结果和汇集样本。这种类型的合作研究往往是困难的。在强迫症基金会和NIMH的资助下，这组研究人员正在合作进行第一项强迫症全基因组关联研究。目前，来自19个不同地点的调查人员已同意将他们的强迫症样本联合收割机合并。总样本包括约4，500名个人，1，800名单身人士和800名由一名受影响的个人和两名父母组成的三合会。预计全球WAS的结果将在2008年12月之前公布。因此，本提案的目的是获得资金，使该小组能够继续开会，进一步建立合作工作组，重点关注强迫症遗传学的不同方面。这是一个会议补助金的竞争延续申请，该补助金在过去四年中资助了强迫症基金会遗传学合作（OCFGC）的会议。OCFGC的主要目标是开展强迫症分子遗传学的合作研究。在过去的两年中，OCFGC进行了一项强迫症的全基因组关联研究，该研究应该确定这种疾病的易感基因。

DESCRIPTION (provided by applicant): This is a competing renewal of a multi-year conference grant that has supported a forum for researchers to pursue collaborative studies of the molecular genetics of obsessive compulsive disorder (OCD). This application is consistent with NIMH initiatives to facilitate meetings in which researchers come together to establish mechanisms for collaborating in a manner that would facilitate the detection of genes predisposing to psychiatric disorders. At the present time, there are approximately 60 researchers who have attended the meetings of this group. These individuals come from 38 different research centers in 13 foreign countries and the United States. OCD is a serious psychiatric condition that can have debilitating affects on both adults and children. The importance of genetic factors in OCD has been demonstrated by twin and family aggregation studies. Furthermore, recent molecular genetic studies have begun to provide evidence that specific genes may play a role in the manifestation of the disorder. Although these preliminary results are encouraging, several considerations suggest that fully clarifying the genetic architecture of OCD will require large samples and collaborative efforts. It is clear from ongoing studies of the genetics of schizophrenia, autism, Gilles de la Tourette's syndrome, ADHD and bipolar disorder that are consistent with statistical considerations regarding the power to locate genes for complex disorders, that samples collected by individual investigators may not be sufficiently large to provide significant evidence for genetic linkage. Furthermore, once linkage has been demonstrated, even larger samples sizes are needed to identify and characterize susceptibility genes. Thus, it is clear that coordinated collaboration is needed to share findings and pool samples. Cooperative research of this type is often difficult. With the support of the Obsessive Compulsive Foundation and this grant from NIMH, this group of investigators is collaborating on the first Genome Wide Association Study of OCD. At the present time, investigators from 19 different sites have agreed to combine their OCD samples. The total sample consists of approximately 4,500 individuals, 1,800 singleton cases and 800 triads consisting of an affected individual and two parents. It is expected that the results of this GWAS will be published before December 2008. Thus, the aim of this proposal is to obtain funding that will allow this group to continue meeting to further establish collaborative working groups focused on different aspects of the genetics of OCD. This is a competing continuation application of a meeting grant that has funded meetings of the Obsessive Compulsive Foundation Genetics Collaborative (OCFGC) over the last four years. The major goal of the OCFGC is to develop collaborative studies of the molecular genetics of obsessive- compulsive disorder. Over the last 2 years, the OCFGC has undertaken a Whole Genome Association Study for OCD that should identify susceptibility genes for this disorder.