OC Foundation Genetics Collaborative Conference

OC基金会遗传学合作会议

• 批准号: 6887981
• 负责人: DAVID L PAULS
• 金额: $ 11.53万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-23 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6887981
• 关键词: genetic susceptibility; meeting /conference /symposium; molecular genetics; obsessive compulsive disorder; travel

DESCRIPTION (provided by applicant): A multi-year conference grant is being proposed to support a forum for researchers to pursue collaborative studies of the molecular genetics of obsessive compulsive disorder (OCD). This application is consistent with NIMH initiatives to facilitate meetings in which researchers come together to establish mechanisms for collaborating in a manner that would facilitate the detection of genes predisposing to psychiatric disorders. At the present time, there are approximately 50 researchers who have attended the first two meetings of this group. These individuals come from 12 foreign countries and from 13 different research centers in the United States. The group has already met twice and will be meeting again in April 2004. OCD is a serious psychiatric condition that can have debilitating affects on both adults and children. The importance of genetic factors in OCD has been demonstrated by twin and family aggregation studies. Furthermore, recent molecular genetic studies have begun to provide evidence that specific genes may play a role in the manifestation of the disorder. Although these preliminary results are encouraging, several considerations suggest that fully clarifying the genetic architecture of OCD will require large samples and collaborative efforts. It is clear from ongoing studies of the genetics of schizophrenia, autism, Gilles de la Tourette's syndrome, ADHD and bipolar disorder that are consistent with statistical considerations regarding the power to locate genes for complex disorders, that samples collected by individual investigators may not be sufficiently large to provide significant evidence for genetic linkage. Furthermore, once linkage has been demonstrated, even larger sample sizes are needed to identify and characterize susceptibility genes. Thus, it is clear that coordinated collaboration is needed to share findings and pool samples. Cooperative research of this type is often difficult. With the support of the Obsessive Compulsive Foundation, a group of investigators (described above) from around the world (the OCF Genetics Collaborative) have already begun to meet to address some of these issues. The OCF has funded the first two meetings of this group. However, its funds are limited and for the most part, donors to the OCF Research Fund indicate that they want the funds that they give to support specific research projects rather than meetings. Thus, the aim of this proposal is to obtain funding that will allow this group to continue meeting to establish collaborative working groups focused on different aspects of the genetics of OCD. The hope is that data from a variety of studies being done collaboratively among members of the group will be easily combined and stored in a general data repository to be used initially by all members of the OCF Genetics Collaborative and eventually by members of the scientific community at large.

描述(由申请人提供)：一项为期多年的会议拨款被提议用于支持一个论坛，让研究人员继续对强迫症(OCD)的分子遗传学进行合作研究。这一应用与NIMH促进会议的倡议是一致的，在这些会议上，研究人员聚集在一起，以一种有助于检测易患精神疾病的基因的方式建立合作机制。目前，大约有50名研究人员参加了该小组的头两次会议。这些人来自12个国家 来自外国和美国的13个不同的研究中心。该小组已经举行了两次会议，并将于2004年4月再次举行会议。强迫症是一种严重的精神疾病，对成年人和儿童都会产生衰弱的影响。遗传因素在强迫症中的重要性已被双胞胎和家庭聚集性研究证明。此外，最近的分子遗传学研究已经开始提供证据，证明特定的基因可能在这种疾病的表现中发挥作用。 尽管这些初步结果令人鼓舞，但一些考虑表明，充分阐明强迫症的遗传结构将需要大样本和合作努力。从正在进行的精神分裂症、自闭症、抽动症、多动症和双相情感障碍的遗传学研究中可以清楚地看出，个别研究人员收集的样本可能不够大，不足以为遗传联系提供重要证据。这些研究符合关于复杂疾病基因定位能力的统计考虑。此外，一旦证实了连锁，就需要更大的样本量来识别和表征易感基因。因此，显然需要进行协调合作，以分享调查结果和汇集样本。这种类型的合作研究往往是困难的。在强迫症基金会的支持下，来自世界各地的一组研究人员(如上所述)(OCF遗传学协作组)已经开始开会解决其中一些问题。OCF为该小组的头两次会议提供了资金。然而，它的资金是 OCF研究基金的捐赠者数量有限，而且在很大程度上表明，他们希望获得用于支持具体研究项目的资金，而不是会议。因此，这项提议的目的是获得资金，使该小组能够继续开会，建立侧重于强迫症遗传学不同方面的合作工作组。希望小组成员之间合作完成的各种研究的数据将很容易地组合在一起，并存储在一个通用的数据储存库中，最初供OCF Genetics Collaborative的所有成员使用，最终供整个科学界成员使用。