OC Foundation Genetics Collaborative Conference

OC基金会遗传学合作会议

• 批准号: 7267782
• 负责人: DAVID L PAULS
• 金额: $ 11.91万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-23 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7267782
• 关键词: Address; Adult; Affect; Anxiety; Architecture; Attention deficit hyperactivity disorder; Autistic Disorder; Behavior; Biochemical; Biological; Bipolar Disorder; Candidate Disease Gene; Categories; Child; Classification; Clinical; Collaborations; Communities; Complex; Condition; Country; Data; Data Analyses; Data Set; Databases; Detection; Diagnosis; Diagnostic; Disease; Dizygotic Twins; Equipment and supply inventories; Etiology; Family; Family Study; Female; Focus Groups; Foundations; Funding; Genes; Genetic; Genetic Predisposition to Disease; Gilles de la Tourette syndrome; Grant; Group Meetings; Heritability; Individual; Interview; Measurement; Mental disorders; Molecular Genetics; Monozygotic Twinning; Monozygotic twins; Multivariate Analysis; National Institute of Mental Health; Nature; Neurotic Disorders; Numbers; Obsessive compulsive behavior; Obsessive-Compulsive Disorder; Pattern; Personality; Phenotype; Play; Prevalence; Questionnaires; Range; Rate; Registries; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resources; Role; Sample Size; Sampling; Schizophrenia; Series; Site; Structure; Susceptibility Gene; Symptoms; Thinking; Time; Twin Multiple Birth; Twin Studies; United States; Work; base; clinical phenotype; expectation; genetic linkage; innovation; instrument; male; member; neuroimaging; sex; size; symposium; trait

DESCRIPTION (provided by applicant): A multi-year conference grant is being proposed to support a forum for researchers to pursue collaborative studies of the molecular genetics of obsessive compulsive disorder (OCD). This application is consistent with NIMH initiatives to facilitate meetings in which researchers come together to establish mechanisms for collaborating in a manner that would facilitate the detection of genes predisposing to psychiatric disorders. At the present time, there are approximately 50 researchers who have attended the first two meetings of this group. These individuals come from 12 foreign countries and from 13 different research centers in the United States. The group has already met twice and will be meeting again in April 2004. OCD is a serious psychiatric condition that can have debilitating affects on both adults and children. The importance of genetic factors in OCD has been demonstrated by twin and family aggregation studies. Furthermore, recent molecular genetic studies have begun to provide evidence that specific genes may play a role in the manifestation of the disorder. Although these preliminary results are encouraging, several considerations suggest that fully clarifying the genetic architecture of OCD will require large samples and collaborative efforts. It is clear from ongoing studies of the genetics of schizophrenia, autism, Gilles de la Tourette's syndrome, ADHD and bipolar disorder that are consistent with statistical considerations regarding the power to locate genes for complex disorders, that samples collected by individual investigators may not be sufficiently large to provide significant evidence for genetic linkage. Furthermore, once linkage has been demonstrated, even larger sample sizes are needed to identify and characterize susceptibility genes. Thus, it is clear that coordinated collaboration is needed to share findings and pool samples. Cooperative research of this type is often difficult. With the support of the Obsessive Compulsive Foundation, a group of investigators (described above) from around the world (the OCF Genetics Collaborative) have already begun to meet to address some of these issues. The OCF has funded the first two meetings of this group. However, its funds are limited and for the most part, donors to the OCF Research Fund indicate that they want the funds that they give to support specific research projects rather than meetings. Thus, the aim of this proposal is to obtain funding that will allow this group to continue meeting to establish collaborative working groups focused on different aspects of the genetics of OCD. The hope is that data from a variety of studies being done collaboratively among members of the group will be easily combined and stored in a general data repository to be used initially by all members of the OCF Genetics Collaborative and eventually by members of the scientific community at large.

描述（由申请人提供）：一个多年的会议补助金被提议支持一个论坛，研究人员进行强迫症（OCD）的分子遗传学的合作研究。该应用程序与NIMH倡议一致，以促进研究人员聚集在一起建立合作机制的会议，以促进检测易患精神疾病的基因。目前，大约有50名研究人员参加了该小组的前两次会议。这些人来自12个 来自国外和美国13个不同的研究中心。该小组已经举行了两次会议，并将于2004年4月再次举行会议。强迫症是一种严重的精神疾病，对成人和儿童都有衰弱的影响。遗传因素在强迫症中的重要性已被双胞胎和家庭聚集研究所证实。此外，最近的分子遗传学研究已经开始提供证据表明，特定的基因可能在这种疾病的表现中发挥作用。 虽然这些初步结果令人鼓舞，但一些考虑因素表明，完全澄清强迫症的遗传结构将需要大量样本和合作努力。从正在进行的精神分裂症、自闭症、抽动秽语综合征、多动症和双相情感障碍的遗传学研究中可以清楚地看出，个体研究者收集的样本可能不够大，无法为遗传连锁提供重要证据。此外，一旦连锁已经证明，甚至需要更大的样本量来识别和表征易感基因。因此，显然需要协调合作，以分享调查结果和汇集样本。这种类型的合作研究往往是困难的。在强迫症基金会的支持下，来自世界各地的一组研究人员（如上所述）（OCF遗传学合作组织）已经开始开会解决其中的一些问题。货币基金组织为该小组的头两次会议提供了资金。然而，其资金 OCF研究基金的捐助者表示，他们希望他们提供的资金用于支持特定的研究项目，而不是会议。因此，本提案的目的是获得资金，使该小组能够继续开会，建立专注于强迫症遗传学不同方面的合作工作组。希望来自该小组成员之间合作完成的各种研究的数据将很容易地组合并存储在一个通用数据库中，最初由OCF遗传学协作的所有成员使用，最终由整个科学界的成员使用。