OC Foundation Genetics Collaborative Conference

OC基金会遗传学合作会议

• 批准号: 7267782
• 负责人: DAVID L PAULS
• 金额: $ 11.91万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-23 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7267782
• 关键词: Address; Adult; Affect; Anxiety; Architecture; Attention deficit hyperactivity disorder; Autistic Disorder; Behavior; Biochemical; Biological; Bipolar Disorder; Candidate Disease Gene; Categories; Child; Classification; Clinical; Collaborations; Communities; Complex; Condition; Country; Data; Data Analyses; Data Set; Databases; Detection; Diagnosis; Diagnostic; Disease; Dizygotic Twins; Equipment and supply inventories; Etiology; Family; Family Study; Female; Focus Groups; Foundations; Funding; Genes; Genetic; Genetic Predisposition to Disease; Gilles de la Tourette syndrome; Grant; Group Meetings; Heritability; Individual; Interview; Measurement; Mental disorders; Molecular Genetics; Monozygotic Twinning; Monozygotic twins; Multivariate Analysis; National Institute of Mental Health; Nature; Neurotic Disorders; Numbers; Obsessive compulsive behavior; Obsessive-Compulsive Disorder; Pattern; Personality; Phenotype; Play; Prevalence; Questionnaires; Range; Rate; Registries; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resources; Role; Sample Size; Sampling; Schizophrenia; Series; Site; Structure; Susceptibility Gene; Symptoms; Thinking; Time; Twin Multiple Birth; Twin Studies; United States; Work; base; clinical phenotype; expectation; genetic linkage; innovation; instrument; male; member; neuroimaging; sex; size; symposium; trait

DESCRIPTION (provided by applicant): A multi-year conference grant is being proposed to support a forum for researchers to pursue collaborative studies of the molecular genetics of obsessive compulsive disorder (OCD). This application is consistent with NIMH initiatives to facilitate meetings in which researchers come together to establish mechanisms for collaborating in a manner that would facilitate the detection of genes predisposing to psychiatric disorders. At the present time, there are approximately 50 researchers who have attended the first two meetings of this group. These individuals come from 12 foreign countries and from 13 different research centers in the United States. The group has already met twice and will be meeting again in April 2004. OCD is a serious psychiatric condition that can have debilitating affects on both adults and children. The importance of genetic factors in OCD has been demonstrated by twin and family aggregation studies. Furthermore, recent molecular genetic studies have begun to provide evidence that specific genes may play a role in the manifestation of the disorder. Although these preliminary results are encouraging, several considerations suggest that fully clarifying the genetic architecture of OCD will require large samples and collaborative efforts. It is clear from ongoing studies of the genetics of schizophrenia, autism, Gilles de la Tourette's syndrome, ADHD and bipolar disorder that are consistent with statistical considerations regarding the power to locate genes for complex disorders, that samples collected by individual investigators may not be sufficiently large to provide significant evidence for genetic linkage. Furthermore, once linkage has been demonstrated, even larger sample sizes are needed to identify and characterize susceptibility genes. Thus, it is clear that coordinated collaboration is needed to share findings and pool samples. Cooperative research of this type is often difficult. With the support of the Obsessive Compulsive Foundation, a group of investigators (described above) from around the world (the OCF Genetics Collaborative) have already begun to meet to address some of these issues. The OCF has funded the first two meetings of this group. However, its funds are limited and for the most part, donors to the OCF Research Fund indicate that they want the funds that they give to support specific research projects rather than meetings. Thus, the aim of this proposal is to obtain funding that will allow this group to continue meeting to establish collaborative working groups focused on different aspects of the genetics of OCD. The hope is that data from a variety of studies being done collaboratively among members of the group will be easily combined and stored in a general data repository to be used initially by all members of the OCF Genetics Collaborative and eventually by members of the scientific community at large.

描述（由申请人提供）：一项为期多年的会议资助被提议用于支持研究人员进行强迫性精神障碍（OCD）分子遗传学合作研究的论坛。这一应用与NIMH促进会议的倡议是一致的，在会议上，研究人员聚集在一起，建立合作机制，以一种促进检测易导致精神疾病的基因的方式。目前，大约有50名研究人员参加了该小组的前两次会议。这些个体来自12个