Generation and maintenance of effective T cell memory in peripheral organs

外周器官中有效 T 细胞记忆的生成和维持

• 批准号: nhmrc : 628423
• 负责人: A/Pr Thomas Gebhardt
• 金额: $ 22.46万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/generation-maintenance-effective-peripheral-organs/80771
• 关键词: Generation; maintenance; effective; cell; memory

Infectious diseases represent potentially life-threatening events. Immunity against re-infection relies on different types of memory immune cells that constantly patrol through the organism in search for invading agents. Recently, it has emerged that there exists an additional type of memory cells that permanently reside in peripheral tissues where they confer immediate immune protection. This project will examine the requirements for the generation and maintenance of this important cell type.

传染病是潜在的危及生命的事件。对再次感染的免疫力依赖于不同类型的记忆免疫细胞，这些细胞不断地在生物体中巡逻，寻找入侵者。最近，人们发现存在另外一种类型的记忆细胞，它们永久地驻留在外周组织中，在那里它们赋予立即的免疫保护。本项目将研究这一重要细胞类型的生成和维持的要求。