Training the Next Generation of Innovative and Collaborative Patient-Oriented Researchers to Reduce Obesity and Improve Cardiometabolic Health

培训下一代创新和协作的以患者为中心的研究人员，以减少肥胖并改善心脏代谢健康

• 批准号: 10721553
• 负责人: VICTORIA A CATENACCI
• 金额: $ 12.61万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-10 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10721553
• 关键词: Acceleration; Achievement; Address; Adult; Advisory Committees; Ancillary Study; Atrial Fibrillation; Award; Behavior; Behavior Therapy; Behavioral; Biological; Blood Pressure; Body Weight decreased; Body mass index; Caloric Restriction; Cardiometabolic Disease; Cardiovascular Diseases; Career Mobility; Chronic Disease; Clinical; Clinical Investigator; Collaborations; Complex; Conduct Clinical Trials; Coronary Arteriosclerosis; Data; Dedications; Development; Diet; Doctor of Philosophy; Eating; Energy Intake; Energy Metabolism; Ensure; Epidemic; Evidence based intervention; Exercise; Faculty; Food; Funding; Glycosylated hemoglobin A; Goals; Grant; Health; Heart failure; High Density Lipoprotein Cholesterol; Individual; Infrastructure; Institution; Interdisciplinary Study; Intermittent fasting; Intervention; Intervention Trial; K-Series Research Career Programs; Knowledge; Leadership; Life Style; Maintenance; Measures; Medical Students; Medicine; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Morbid Obesity; Obesity; Participant; Patient Education; Pattern; Persons; Physical activity; Physicians; Physiology; Positioning Attribute; Postdoctoral Fellow; Prediction of Response to Therapy; Prevalence; Productivity; Public Health; Publications; Recording of previous events; Research; Research Personnel; Research Training; Resources; Risk; Risk Factors; Risk Reduction; Role; Scientist; Sleep; Sleep Deprivation; Time; Training; Training Programs; Translating; Triglycerides; Unhealthy Diet; United States National Institutes of Health; Weight; Weight maintenance regimen; cardiometabolism; cardiovascular disorder risk; career; circadian; clinical training; design; disorder risk; effective intervention; evidence base; experience; graduate student; improved; innovation; interdisciplinary collaboration; interest; lifestyle intervention; next generation; novel; nutrition; obesity development; obesity treatment; patient oriented; patient oriented research; programs; psychosocial; response; secondary analysis; skill acquisition; skills; success; training opportunity; treatment research; treatment response; trial design; undergraduate student; weight loss intervention; weight loss program; weight maintenance

PROJECT SUMMARY/ABSTRACT My career focuses on research, clinical, and translational efforts to improve lifestyle treatment for obesity. Obesity is a major contributor to cardiovascular disease (CVD), accelerated by the current epidemic of highly palatable energy dense food, reduced physical activity, and insufficient sleep. While weight loss can reduce CVDrisk, sustaining weight loss is a major challenge for most individuals with obesity. It is imperative to identify innovative and evidence-based strategies to promote greater and more durable weight loss. My collaborative research program focuses on understanding predictors of successful weight loss maintenance and translating those findings into strategies to improve lifestyle weight management programs. Specifically, I develop and evaluate novel weight loss interventions, focusing on alterations of the timing or pattern of energy intake and physical activity (PA). My studies involve rigorous, objective measures of free-living energy expenditure and energy intake, and multi-disciplinary collaborations to comprehensively assess potential biologic, behavioral, psychosocial, and environmental predictors of treatment response. Collectively, these studies provide a framework and wealth of data for trainees to perform hypothesis-driven patient-oriented research (POR). I am deeply committed to mentoring the next generation of innovative, collaborative clinical researchers to reduce obesity and cardiometabolic disease risk. I have 8 years of mentoring experience supporting new and early- stage clinical investigators in POR (undergraduate, graduate, and medical students; MD and PhD post-doctoral research fellows; and junior faculty). My mentees have an excellent record of publication productivity, NIH grant funding, successful career transitions, and retention in academic medicine. The K24 Mid-Career Investigator Award will provide dedicated time for me to deliver focused mentorship to junior clinical investigators of exceptional potential and capitalize on the outstanding mentoring, research, and training resources of our campus. I will pursue leadership and administrative training, as well as develop multidisciplinary collaborations to enhance my knowledge and skills in sleep/circadian physiology and qualitative methodology to extend the breadth and reach of my obesity treatment POR program. I have assembled an experienced team of senior clinical researchers with extensive mentorship experience and leadership roles in clinical and research training programs on campus to serve as a K24 Advisory Committee to guide me during the K24 award period. My specific aims are to 1) Mentor junior clinical investigators to create a pipeline of well-trained patient-oriented researchers focused on obesity, nutrition, PA, and sleep, and 2) Build and enhance my collaborative research program designed to rigorously evaluate strategies involving alterations of the timing or pattern of behaviors (diet, PA, and sleep) to develop more effective lifestyle interventions to treat obesity, reduce cardiometabolic disease, and improve health. As a dedicated physician-scientist, I am well-positioned to enhance the quality and breadth of POR in weight management and CVD risk reduction and become a national leader in this field.

项目摘要/摘要 我的职业重点是研究，临床和翻译工作，以改善肥胖的生活方式治疗。 肥胖是心血管的主要因素 疾病 （CVD）， 由高度的当前流行加速 可口的能量致密食物，体育锻炼减少和睡眠不足。减肥可以减少 对于大多数肥胖症患者而言，维持体重减轻是一个主要挑战。必须识别 创新和基于证据的策略，以促进更大，更耐用的体重减轻。我的合作 研究计划的重点是理解成功减肥和翻译的预测指标 这些发现是改善生活方式体重管理计划的策略。具体来说，我发展和 评估新颖的减肥干预措施，重点是改变能量摄入的时间或模式和 体育活动（PA）。我的研究涉及对自由生活能源消耗的严格，客观的衡量和 能源摄入和多学科合作，以全面评估潜在的生物学，行为， 社会心理和治疗反应的环境预测指标。总的来说，这些研究提供了 框架和大量数据供受训者执行以假设为导向的患者研究（POR）。我是 深入致力于指导下一代创新的协作临床研究人员，以减少 肥胖和心脏代谢疾病风险。我有8年的指导经验，以支持新的和早期 - POR（本科，研究生和医学生；医学博士和博士后博士学位的阶段临床研究者 研究研究员；和初级教师）。我的受训者有出版物生产率的出色记录，NIH Grant 资金，成功的职业过渡和学术医学保留。 K24中级研究员 奖项将为我提供专门的时间，向初级临床调查人员提供专注的指导 极具潜力，并利用我们的杰出指导，研究和培训资源 校园。我将进行领导和行政培训，并建立多学科合作 为了增强我在睡眠/昼夜节律生理学和定性方法方面的知识和技能以扩展 我的肥胖治疗计划的广度和范围。我组建了一支经验丰富的高级团队 具有丰富的指导经验和领导角色在临床和研究培训中的领导角色的临床研究人员 在校园内担任K24咨询委员会的计划，以指导我在K24奖励期间。我的 具体目的是1）指导初级临床研究人员创建以训练有素的患者培训的管道 研究人员专注于肥胖，营养，宾夕法尼亚州和睡眠，2）建立和增强我的协作研究 计划旨在严格评估涉及行为时机或模式改变的策略 （饮食，PA和睡眠）为了制定更有效的生活方式干预措施以治疗肥胖症，减少心脏代谢 疾病并改善健康。作为专门的医师科学家，我有很好的位置，以提高质量和 体重管理和CVD风险降低的广度，并成为该领域的国家领导者。