权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Amphibian Disease Dynamics in a Fragmented Landscape

破碎景观中的两栖动物疾病动态

基本信息

批准号：
7066613
负责人：
CHERYL J BRIGGS
金额：
$ 43.94万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-06-01 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7066613
关键词：
Fungi Rana animal population study environmental adaptation epizootiology host organism interaction mathematical model model design /development mycosis zoonosis

项目摘要

DESCRIPTION (provided by applicant): The newly identified fungal pathogen, Batrachochytrium, has recently been implicated as causing the decline of amphibians worldwide. We aim to determine the origin of chytridiomycosis (the disease caused by Batrachochytrium), and understand how anthropogenic environmental changes influence its prevalence and spread. Our research will focus specifically on the relationship between Batrachochytrium and the mountain yellow-legged frog (Rana muscosa), a once-common amphibian in California's Sierra Nevada mountains. R. muscosa is an ideal study host as it is still common enough despite population declines to be used in experiments, and populations are strongly influenced by chytridiomycosis infection. As with animal populations throughout the world, amphibians in the Sierra Nevada are being subjected to an increasing array of anthropogenic stressors including exotic species introductions, habitat fragmentation, and chemical contaminants and these may change the prevalence and spread of disease. Using a team with expertise in pathogenic fungi, epidemiology, amphibian ecology, population genetics, and statistical and mechanistic modeling, our specific objectives are to: 1) describe the origin of Batrachochytrium to determine whether its association with amphibians in the Sierra Nevada represents an old association or a recent expansion of the fungus into previously uninfected frogs; 2) describe the effect of infection and spread on frog population dynamics using temporal resurveys of sites identified from an existing database of 4,500 water bodies in the Sierra Nevada; 3) develop statistical models to describe the effect of nonnative fish, habitat fragmentation, and windborne agricultural contaminants on the distribution of frogs and chytridiomycosis; and 4) develop detailed mechanistic models to predict the likely effects of various biological mechanisms (both natural and anthropogenic) on the incidence, spatial distribution, and persistence of chytridiomycosis, and to predict the impact of this disease on the abundance and dynamics of R. muscosa. Given the paucity of studies of disease in animal populations in the wild, the results of our study will provide important insights into disease dynamics in other systems, and aid in efforts to protect biodiversity in the face of emerging infectious diseases.

描述(申请人提供)：新鉴定的真菌病原菌， Batrachochytrium，最近被认为是导致世界各地的两栖动物。我们的目标是确定壶菌病的起源( 由巴氏杆菌引起的疾病)，并了解人类如何环境变化影响其流行和传播。我们的研究将特别关注巴氏杆菌与山地黄腿蛙(Rana Muscoa)，曾是我国常见的两栖动物加利福尼亚州的内华达山脉。因此，蝴蝶是一种理想的研究宿主。尽管种群数量减少了，但仍然很常见，可以用于实验，而且人群受到旋毛菌病感染的强烈影响。和以前一样在世界各地，内华达山脉的两栖动物是承受着越来越多的人为应激源，包括外来物种引进、栖息地碎片化和化学污染物这些可能会改变疾病的流行和传播。将团队与病原真菌、流行病学、两栖动物生态学、种群方面的专业知识遗传学，统计和机械建模，我们的具体目标目的是：1)描述巴氏杆菌的来源，以确定其内华达山脉的两栖动物协会代表了一个古老的协会或最近这种真菌扩展到以前未感染的青蛙中；2) 描述感染和传播对青蛙种群动态的影响从现有的4500个数据库中确定的地点的临时复查内华达山脉的水体；3)开发统计模型来描述外来鱼类、栖息地碎片化和风媒的影响农业污染物对青蛙和棘球菌病分布的影响；以及4)开发详细的机制模型来预测可能的影响不同的生物机制(包括自然和人为)对旋毛菌病的发病率、空间分布和持久性，以及预测该病对R.R.丰度和动态的影响。番茄酱。考虑到对动物种群中疾病的研究很少我们的研究结果将为疾病的研究提供重要的见解其他系统的动态，并帮助努力保护生物多样性面对新出现的传染病。

项目成果

期刊论文数量（18）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pathophysiology in mountain yellow-legged frogs (Rana muscosa) during a chytridiomycosis outbreak.

壶菌病爆发期间山黄腿蛙（Rana muscosa）的病理生理学。

DOI：
10.1371/journal.pone.0035374
发表时间：
2012
期刊：
PloS one
影响因子：
3.7
作者：
Voyles,Jamie;Vredenburg,VanceT;Tunstall,TateS;Parker,JohnM;Briggs,CherylJ;Rosenblum,EricaBree
通讯作者：
Rosenblum,EricaBree

Antimicrobial peptide defenses of the mountain yellow-legged frog (Rana muscosa).

黄腿山蛙（Rana muscosa）的抗菌肽防御。

DOI：
10.1016/j.dci.2005.10.005
发表时间：
2006
期刊：
Developmental and comparative immunology
影响因子：
2.9
作者：
Rollins-Smith,LouiseA;Woodhams,DouglasC;Reinert,LauraK;Vredenburg,VanceT;Briggs,CherylJ;Nielsen,PerF;Conlon,JMichael
通讯作者：
Conlon,JMichael

Quantifying the disease transmission function: effects of density on Batrachochytrium dendrobatidis transmission in the mountain yellow-legged frog Rana muscosa.

量化疾病传播函数：密度对山黄腿蛙 Rana muscosa 中 Batrachochytrium dendrobatidis 传播的影响。