Biophysics /Structure /Immunogenicity of HIV-1Glycoprote
Biophysics /Structure /Immunogenicity of HIV-1Glycoprote
批准号:
7189318
负责人:
Richard Thomas Wyatt
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
HIV envelope protein gp120antigen antibody reactionbiophysicsbiotechnologyenzyme linked immunosorbent assayglycoproteinsguinea pigshuman immunodeficiency virus 1human tissuelaboratory mouselaboratory rabbitneutralizing antibodypolymerase chain reactionprotein purificationprotein structureprotein structure functionrecombinant DNAstructural biologytransfectionvaccine development
中文摘要
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英文摘要
In this study, we have produced soluble versions of Env glycoproteins derived from a primary isolate stabilized by Phe 43 pocket filling mutations and inter-domain cysteine bonds. We have tested these glycoproteins for immunogenicity in rabbits as a prime for soluble gp140 molecule boost. Breadth of neutralization indicate that these glycoproteins significantly increase neutralization breadth as a prime for the soluble gp140 trimer boosts and both are interesting platforms for further modification to better elicit broadly neutralizing antibodies.
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Core-002
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批准号:10794904
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项目类别:
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资助金额:$113.05万
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财政年份:2021
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负责人:Richard Thomas Wyatt
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依托单位:
Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates
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批准号:10339439
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项目类别:
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资助金额:$342.0万
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财政年份:2021
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负责人:Richard Thomas Wyatt
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依托单位:
Project 1
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批准号:10339443
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项目类别:
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资助金额:$115.59万
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财政年份:2021
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负责人:Richard Thomas Wyatt
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依托单位:
Admin Core
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批准号:10339440
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项目类别:
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资助金额:$21.4万
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财政年份:2021
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负责人:Richard Thomas Wyatt
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依托单位:
Core-001
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批准号:10782243
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项目类别:
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资助金额:$139.64万
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财政年份:2021
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负责人:Richard Thomas Wyatt
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依托单位:
Project-002
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批准号:10794919
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项目类别:
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资助金额:$50.33万
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财政年份:2021
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负责人:Richard Thomas Wyatt
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依托单位:
Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates
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批准号:10549838
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项目类别:
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资助金额:$340.27万
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财政年份:2021
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负责人:Richard Thomas Wyatt
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依托单位:
Admin-Core-001
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批准号:10794918
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项目类别:
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资助金额:$37.25万
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财政年份:2021
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负责人:Richard Thomas Wyatt
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依托单位:
N-glycan baiting to target the highly effective HIV Env shield
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批准号:10388295
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项目类别:
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资助金额:$96.18万
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财政年份:2019
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负责人:Richard Thomas Wyatt
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依托单位:
N-glycan baiting to target the highly effective HIV Env shield
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批准号:9754560
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项目类别:
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资助金额:$67.15万
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财政年份:2019
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负责人:Richard Thomas Wyatt
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依托单位:
N-glycan baiting to target the highly effective HIV Env shield
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批准号:10333202
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项目类别:
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资助金额:$96.18万
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财政年份:2019
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负责人:Richard Thomas Wyatt
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依托单位:
N-glycan baiting to target the highly effective HIV Env shield
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批准号:9918868
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项目类别:
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资助金额:$67.15万
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财政年份:2019
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负责人:Richard Thomas Wyatt
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依托单位:
High Resolution Analysis of Env-directed B Cells to Accelerate Vaccine Design
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批准号:8680621
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项目类别:
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资助金额:$265.98万
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财政年份:2014
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负责人:Richard Thomas Wyatt
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依托单位:
Structure and Immunogenicity of HIV-1 gp41 Membrane Prox
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批准号:7299877
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Richard Thomas Wyatt
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依托单位:
Immmunogenicity and Structure of trimeric HIV-1 gp120 gl
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批准号:7184287
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Richard Thomas Wyatt
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依托单位:
HIV-1 Solid Phase Proteoliposome
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批准号:7184256
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Richard Thomas Wyatt
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依托单位:
Production And Characterization Of HIV-1 Solid Phase Proteoliposomes
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批准号:7732748
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项目类别:
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资助金额:$41.47万
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财政年份:--
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负责人:Richard Thomas Wyatt
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依托单位:
Determination of the Neutralization Specificity in Broadly Neutralizing HIV Sera
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批准号:7592436
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项目类别:
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资助金额:$19.16万
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财政年份:--
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负责人:Richard Thomas Wyatt
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依托单位:
Administrative Core
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批准号:8829138
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项目类别:
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资助金额:$10.27万
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财政年份:--
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负责人:Richard Thomas Wyatt
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依托单位:
Administrative Core
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批准号:8680626
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项目类别:
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资助金额:$11.26万
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财政年份:--
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负责人:Richard Thomas Wyatt
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依托单位:
海外基金