课题基金 / 基金详情

Biophysics /Structure /Immunogenicity of HIV-1Glycoprote

Biophysics /Structure /Immunogenicity of HIV-1Glycoprote
HIV-1糖蛋白的生物物理学/结构/免疫原性
批准号:
7189318
负责人:
Richard Thomas Wyatt
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:

项目摘要

项目成果

Richard Thomas Wyatt的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
In this study, we have produced soluble versions of Env glycoproteins derived from a primary isolate stabilized by Phe 43 pocket filling mutations and inter-domain cysteine bonds. We have tested these glycoproteins for immunogenicity in rabbits as a prime for soluble gp140 molecule boost. Breadth of neutralization indicate that these glycoproteins significantly increase neutralization breadth as a prime for the soluble gp140 trimer boosts and both are interesting platforms for further modification to better elicit broadly neutralizing antibodies.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Core-002
  • 批准号:
    10794904
  • 项目类别:
  • 资助金额:
    $113.05万
  • 财政年份:
    2021
  • 负责人:
    Richard Thomas Wyatt
  • 依托单位:
Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates
  • 批准号:
    10339439
  • 项目类别:
  • 资助金额:
    $342.0万
  • 财政年份:
    2021
  • 负责人:
    Richard Thomas Wyatt
  • 依托单位:
Project 1
  • 批准号:
    10339443
  • 项目类别:
  • 资助金额:
    $115.59万
  • 财政年份:
    2021
  • 负责人:
    Richard Thomas Wyatt
  • 依托单位:
Admin Core
  • 批准号:
    10339440
  • 项目类别:
  • 资助金额:
    $21.4万
  • 财政年份:
    2021
  • 负责人:
    Richard Thomas Wyatt
  • 依托单位:
海外基金