Electrochemical Sensor Technology for Point-of-Care Diagnostics

用于即时诊断的电化学传感器技术

• 批准号: 2883400
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2883400
• 关键词: Electrochemical; Sensor; Technology; Point; Care

The development of fast, minimally-invasive devices which can provide accurate real-time measurements of the key health markers, dissolved oxygen (O2), carbon dioxide (CO2), pH and lactate is vital for making informed choices quickly regarding patient healthcare. This in turn results in markedly improved outcomes for the individual. Whilst technology exists to measure these markers, it is typically made using large and expensive instrumentation, which can be accessed infrequently in the hospital and enables only snapshot measurements. Lower cost point-of-care (POC) diagnostic devices, which could be used in the hospital and home, requires new approaches to sensor development. Electrochemical sensors have long been of interest due to their miniaturization possibilities and ease-of-use. However, in order to apply to the wider POC diagnostics arena, the electrode/electrolyte and operational system must be optimised for the target analytes of interest and be capable of continuous measurement (where applicable) in a miniaturised, easy to use format. This project aims to develop POC diagnostics, for the analytes identified, by bringing together expertise in electrochemical sensor development, clinical analysis, and novel hydrogel patch technology. Whilst electrochemistry methodology development forms the core of the research, the student can expect to develop skills across a wide range of interdisciplinary areas, including polymer science, data analysis and clinical research methods. Formulation of novel electrolyte materials, biosensor development, analytical analysis techniques, and measurement in real-world samples will complement the electrochemical skills developed. Furthermore, there will be opportunity to develop skills in research presentation to a wide range of audiences, from scientific to clinical, research to public, and experts to general audiences. There will also be opportunities for publication of research in peer-reviewed scientific literature, and possibly IP development.

开发快速、微创的设备，可以提供关键健康标志物、溶解氧（O2）、二氧化碳（CO2）、pH值和乳酸盐的准确实时测量，对于快速做出有关患者医疗保健的明智选择至关重要。这反过来又会显著改善个人的结果。虽然存在测量这些标记物的技术，但通常使用大型且昂贵的仪器进行测量，这些仪器在医院中不经常使用，并且只能进行快照测量。可用于医院和家庭的低成本即时（POC）诊断设备需要新的传感器开发方法。电化学传感器由于其小型化的可能性和易用性而长期受到关注。然而，为了应用于更广泛的POC诊断竞技场，电极/电解质和操作系统必须针对感兴趣的目标分析物进行优化，并且能够以简化的、易于使用的形式进行连续测量（在适用的情况下）。该项目旨在通过汇集电化学传感器开发，临床分析和新型水凝胶贴片技术的专业知识，为识别的分析物开发POC诊断。虽然电化学方法的发展形成了研究的核心，学生可以期望在广泛的跨学科领域，包括聚合物科学，数据分析和临床研究方法的发展技能。新型电解质材料的配方，生物传感器的开发，分析技术和测量在现实世界中的样品将补充电化学技能的发展。此外，将有机会发展研究演示的技能，以广泛的受众，从科学到临床，研究到公众，专家到普通观众。还将有机会在同行评审的科学文献中发表研究成果，并可能开发知识产权。