Risk Factors for Psychopathology in the WHO WMH Surveys

世界卫生组织 WMH 调查中的精神病理学危险因素

• 批准号: 7261959
• 负责人: RONALD C KESSLER
• 金额: $ 97.27万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7261959
• 关键词: Abuse Reporting; Address; Adult; Age; Age at Menarche; Agoraphobia; Alcohols; Anthropology; Anxiety; Anxiety Disorders; Area; Attention deficit hyperactivity disorder; Behavior; Bipolar Disorder; Borderline Personality Disorder; Calibration; Canada; Caregivers; Castes; Causations; Child; Childhood; China; Clinical; Collaborations; Colombia; Communities; Complication; Country; County; Couples; Cuba; DSM-IV; Data; Data Analyses; Data Collection; Data Set; Databases; Dependence; Diagnosis; Diagnostic; Disease; Divorce; Drug abuse; Dysthymic Disorder; Education; Employment; Epidemiologist; Epidemiology; Exposure to; Factor Analysis; Family; Female; Funding; Generalized Anxiety Disorder; German population; Government; Health Surveys; Impulse Control Disorders; Income; India; Individual; Informed Consent; Intermittent Explosive Disorders; International; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Interview; Interviewer; Investigation; Investments; Japanese Population; Language; Laws; Long-Term Effects; Marriage; Measures; Medical; Mental Health; Mental disorders; Monitor; Mood Disorders; Needs Assessment; Nepal; New Zealand; Nicotine Dependence; Northern Ireland; Numbers; Obsessive-Compulsive Disorder; Occupations; Oppositional Defiant Disorder; Oral Contraceptives; Outcome; Ownership; Panic; Panic Disorder; Pathological Gambling; Pattern; Personal Satisfaction; Personality Disorders; Population; Positioning Attribute; Postdoctoral Fellow; Pregnancy; Prevalence; Principal Investigator; Probability; Production; Prohibit; Property Rights; Prospective Studies; Psychopathology; Psychotic Disorders; Published Comment; Quality Control; Range; Rate; Recording of previous events; Registries; Reporting; Reproductive Health; Research; Research Personnel; Residual state; Resources; Respondent; Retrospective Studies; Risk Factors; Role; Sample Size; Sampling; Scanning; Sex Characteristics; Site; Social Class; Social Phobia; Societies; South Africa; Specific Phobia; Structure; Substance Use Disorder; Surveys; System; Thinking; Time; Training; Traumatic Stress Disorders; Ukraine; Variant; Woman; World Bank; World Health Organization; Writing; Youth; abuse victim; anti social; authority; birth control; comparative; cost; design; instrument; interest; intergenerational; medical schools; men; neglect; parity; programs; prospective; response; single episode major depressive disorder; size; social

DESCRIPTION (provided by applicant): This proposal is a second resubmission of an earlier proposal that was submitted in response to PA-03-044 (Risk Factors for Psychopathology Using Existing Data Sets) to carry out comprehensive centralized secondary analyses of risk factors in the World Health Organization World Mental Health (WMH) surveys. The WMH surveys are a coordinated set of community psychiatric epidemiological surveys in 28 countries with a combined sample size of over 214,000 respondents. The diagnostic instrument is an expanded version of the WHO Composite International Diagnostic Interview (CIDI). The interviews also include a rich risk factor battery. The surveys are all being carried out by carefully trained and closely monitored lay interviewers, with centralized training and quality control monitoring used to maximize comparability of data across sites. Clinical reappraisal interviews using the Structured Clinical Interview for DSM-IV (SCID) are being administered to sub-samples in a number of sites to confirm the CIDI diagnoses. Most of the 28 surveys are funded only to assess the within-county societal burden of mental disorders, unmet needs for treatment, and barriers to obtaining treatment. Within-country analyses are largely limited to preparing government reports on these basic issues. None of the survey teams is funded to carry out cross-national comparative analyses. We propose to capitalize on this under-use of the WMH survey data by carrying out centralized secondary analyses in collaboration with the international WMH investigators. These secondary analyses will focus on three lines of research, all of which have been of long-standing interest to psychiatric epidemiologists: (1) sex differences in mental illness; (2) the association between social class and mental illness; and (3) the long-term effects of childhood adversities on adult mental illness. The unprecedented size and substantive richness of the WMH database will allow important contributions to be made in each of these three areas of investigation. Three major changes have been made in response to reviewer comments. First, the number of originally proposed lines of investigation was reduced from six to three. Second, we added a second FTE medical anthropology postdoctoral fellow and a senior medical anthropologist Co-Investigator to the team. Third, the level of detail in the description of data analysis plans has been substantially expanded in this revised submission in response to reviewer comments.

描述（由申请人提供）：本提案是针对 PA-03-044（使用现有数据集的精神病理学风险因素）而提交的早期提案的第二次重新提交，旨在对世界卫生组织世界心理健康 (WMH) 调查中的风险因素进行全面的集中二次分析。 WMH 调查是在 28 个国家进行的一系列社区精神病学流行病学调查，总样本量超过 214,000 名受访者。该诊断工具是世界卫生组织综合国际诊断访谈（CIDI）的扩展版本。访谈还包括丰富的风险因素。所有调查均由经过精心培训和严密监控的非专业访谈员进行，并采用集中培训和质量控制监控来最大限度地提高跨站点数据的可比性。正在使用 DSM-IV 结构化临床访谈 (SCID) 对多个地点的子样本进行临床重新评估访谈，以确认 CIDI 诊断。 28 项调查中的大多数仅用于评估县内精神障碍的社会负担、未满足的治疗需求以及获得治疗的障碍。国内分析主要限于准备有关这些基本问题的政府报告。没有一个调查小组获得资助来进行跨国比较分析。我们建议与国际 WMH 研究人员合作进行集中二次分析，以利用 WMH 调查数据利用不足的情况。这些二次分析将集中于三个研究领域，所有这些研究领域长期以来一直引起精神病学流行病学家的兴趣：（1）精神疾病的性别差异； (2)社会阶层与精神疾病之间的关联； (3) 童年逆境对成年精神疾病的长期影响。 WMH 数据库前所未有的规模和实质性丰富性将使我们能够在这三个研究领域中的每一个领域做出重要贡献。根据审稿人的意见，进行了三项重大更改。首先，原定的调查路线从6条减少到3条。其次，我们在团队中增加了第二位 FTE 医学人类学博士后研究员和一位高级医学人类学家联合研究员。第三，根据审稿人的意见，在本次修订后的提交中，数据分析计划描述的详细程度得到了大幅扩展。