Epidemiology - National Comorbidity Survey Replication

描述(由申请人提供)：本申请寻求支持继续分析国家共病调查复制(NCS-R)，这是一个具有全国代表性的家庭调查，对DSM-IV的患病率和相关性进行调查。NCS-R最初的两个具体目标是：通过比较基线NCS结果中的结果，调查1990年代十年间精神障碍患病率和相关性的时间趋势；并将对患病率和相关性的评估扩大到NCS之外。为此，NCS-R重复了许多NCS问题，将诊断评估更新为DSM-IV标准(与基线NCS中的DSM-III-R相比)，扩大了评估的障碍数量，并纳入了许多不在NCS中的新问题。目前的申请有四个具体目标：(1)传播和支持公共使用的NCS-R数据集；(2)完成对NCS-R的分析，目的是研究发病率、治疗、治疗充分性以及与基线NCS相比的时间趋势；(3)完成NCS-R的分析，目的是解决基线NCS中没有涵盖的重要实质性和方法学问题；(4)继续与NIMH和正在进行单独的非洲裔美国人和拉丁美洲/亚裔美国人调查的较大U01中的其他同事合作。第三个目标是四个目标中最复杂的，因为它有六个子目标。这些内容包括：(1)估计个别DSM-IV障碍的患病率、临床严重性和相关性，扩大所评估的障碍的数量和种类；(2)评估旨在指导修订DSM-V系统的障碍特有的病因学问题；(3)估计个别精神和身体障碍对角色功能和效用的比较影响；(4)分析共病增加与个别精神障碍相关的损害的方式；(5)分析精神障碍与身体障碍对家庭负担的影响；以及(Vi)分析多变量共病障碍在生命过程中的时间展开。

DESCRIPTION (provided by applicant): This application seeks support for continued analysis of the National Comorbidity Survey Replication (NCS-R), a nationally representative household survey of the prevalence and correlates of DSM-IV. The two original NCS-R specific aims were: to investigate time trends in the prevalence and correlates of mental disorders over the decade of the 1990s by comparing results in the results of the baseline NCS; and to expand the assessment of prevalence and correlates beyond the NCS. To these ends, the NCS-R repeated many NCS questions, updated diagnostic assessments to DSM-IV criteria (vs. DSM-III-R in the baseline NCS), expanded the number of disorders assessed, and included many new questions not in the NCS. The current application has four specific aims: (1) to disseminate and support a public use NCS-R dataset; (2) to complete analyses for the NCS-R aim of studying time trends in prevalence, treatment, treatment adequacy, and correlates compared to the baseline NCS; (3) to complete analyses for the NCS-R aim of addressing important substantive and methodological issues that were not covered in the baseline NCS; and (4) to continue our collaboration with NIMH and other colleagues in the larger U01 who are carrying out separate African-American and Latino/Asian-American surveys. The third aim is the most complex of the four, as it has six sub-aims. These include the following: (i) to estimate the prevalence, clinical severity, and correlates of individual DSM-IV disorders, expanding the number and variety of disorders assessed compared to the NCS; (ii) to evaluate disorder-specific nosological issues aimed at guiding revisions of the DSM-V system; (iii) to estimate the comparative effects of individual mental and physical disorders on role functioning and utilities; (iv) to analyze the ways in which comorbidity adds to the impairments associated with individual mental disorders; (v) to analyze the effects of mental vs. physical disorders on family burden; and (vi) to analyze the temporal unfolding of multivariate comorbid disorder profiles over the life course.