Epidemiology - National Comorbidity Survey Replication

描述（由申请人提供）：本申请旨在支持国家共病调查复制（NCS-R）的持续分析，这是一项关于DSM-IV患病率和相关性的全国代表性家庭调查。最初的两个NCS- r具体目标是：通过比较基线NCS的结果，调查20世纪90年代精神障碍患病率和相关因素的时间趋势；并将患病率和相关因素的评估扩大到国家统计中心以外。为此，NCS- r重复了许多NCS问题，更新了DSM-IV标准的诊断评估（与基线NCS中的DSM-III-R相比），扩大了评估的疾病数量，并包括了许多NCS中没有的新问题。目前的应用程序有四个具体目标：(1)传播和支持公共使用的NCS-R数据集；(2)完成NCS- r的分析，研究与基线NCS相比，患病率、治疗、治疗充分性和相关因素的时间趋势；(3)完成国家信息系统研究的分析，以解决基线国家信息系统研究未涵盖的重要实质性和方法问题；(4)继续与NIMH和其他在更大的U01的同事合作，他们正在进行单独的非裔美国人和拉丁裔/亚裔美国人调查。第三个目标是四个目标中最复杂的，因为它有六个子目标。这些包括以下内容：(i)估计DSM-IV个体疾病的患病率、临床严重程度和相关性，与NCS相比，扩大评估疾病的数量和种类；（ii）评估旨在指导DSM-V系统修订的特定疾病分类学问题；（iii）评估个体精神和身体障碍对角色功能和效用的比较影响；（iv）分析共病如何加重与个体精神障碍有关的损害；(v)分析精神障碍与身体障碍对家庭负担的影响；(6)分析生命过程中多变量共病的时间展开。

DESCRIPTION (provided by applicant): This application seeks support for continued analysis of the National Comorbidity Survey Replication (NCS-R), a nationally representative household survey of the prevalence and correlates of DSM-IV. The two original NCS-R specific aims were: to investigate time trends in the prevalence and correlates of mental disorders over the decade of the 1990s by comparing results in the results of the baseline NCS; and to expand the assessment of prevalence and correlates beyond the NCS. To these ends, the NCS-R repeated many NCS questions, updated diagnostic assessments to DSM-IV criteria (vs. DSM-III-R in the baseline NCS), expanded the number of disorders assessed, and included many new questions not in the NCS. The current application has four specific aims: (1) to disseminate and support a public use NCS-R dataset; (2) to complete analyses for the NCS-R aim of studying time trends in prevalence, treatment, treatment adequacy, and correlates compared to the baseline NCS; (3) to complete analyses for the NCS-R aim of addressing important substantive and methodological issues that were not covered in the baseline NCS; and (4) to continue our collaboration with NIMH and other colleagues in the larger U01 who are carrying out separate African-American and Latino/Asian-American surveys. The third aim is the most complex of the four, as it has six sub-aims. These include the following: (i) to estimate the prevalence, clinical severity, and correlates of individual DSM-IV disorders, expanding the number and variety of disorders assessed compared to the NCS; (ii) to evaluate disorder-specific nosological issues aimed at guiding revisions of the DSM-V system; (iii) to estimate the comparative effects of individual mental and physical disorders on role functioning and utilities; (iv) to analyze the ways in which comorbidity adds to the impairments associated with individual mental disorders; (v) to analyze the effects of mental vs. physical disorders on family burden; and (vi) to analyze the temporal unfolding of multivariate comorbid disorder profiles over the life course.