LOW DOSE INHALED NITRIC OXIDE TO PREVENT CHRONIC LUNG DISEASE IN PRETERM INFANTS

说明：(申请人提供)本申请的目的是为更新凯斯西储大学(CWRU)医学院的综合临床研究中心(GCRC)寻求资金。主要的GCRC位于克利夫兰大学医院，卫星位于MetroHealth医疗中心(MHMC)。2002年，GCRC为代表CWRU、克利夫兰临床基金会细胞生物学系和营养与营养学部的90名主要调查人员的166项方案提供了支持 克利夫兰州立大学运动生理学专业。作为一家研究机构，CWRU医学院一直保持着国家领导的传统，包括其校友(5人)和教职员工(7人)中的12名诺贝尔奖获得者。这所医学院有1493名全职教职员工。2001年，CWRU的研究人员得到了美国国立卫生研究院超过1.74亿美元的资助。这些奖项包括为癌症、艾滋病、糖尿病、囊性纤维化、高血压、结核病、皮肤病、阿尔茨海默病、软骨再生、呼吸道疾病、新生儿和成人代谢、功能性电刺激、围产期医学和各种类型的遗传缺陷等领域的研究提供的主要资金。2002年，57名CWRU研究人员获得了NIH 100多万美元的支持。2002年，CWRU在美国国立卫生研究院支持的126所医学院中排名第16。该校有15个院系位列相应院系前20名。与最近五年的续展相比，《全球儿童权利公约》调查员的人数增加了17%，使用《全球儿童权利公约》的议定书数量增加了81%，导致出版物数量增加了97%(从201份)。主要研究内容包括：1.肿瘤化疗的生化和分子增强。2.脊髓损伤和卒中后运动的电子恢复。3.囊性纤维化的分子生物学与治疗。4.孕期碳水化合物和蛋白质代谢。5.睡眠呼吸障碍的流行病学、遗传学和病理生理学。6.人类高血压的病理生理学和肾脏转归。7.胎儿胎盘生长发育的影响因素。8.艾滋病毒疾病的病理生理学和治疗。

DESCRIPTION: (provided by applicant) The purpose of this application to seek funding for the renewal of the General Clinical Research Center (GCRC) at Case Western Reserve University (CWRU) School of Medicine. The main GCRC is located at University Hospitals of Cleveland with a satellite at MetroHealth Medical Center (MHMC). In 2002, the GCRC supported 166 protocols for 90 principal investigators representing multiple schools, departments and divisions of CWRU, the Department of Cell Biology at the Cleveland Clinic Foundation, and the Department of Nutrition and Exercise Physiology at Cleveland State University. As a research institute, CWRU's School of Medicine has maintained a tradition of national leadership, including claim to 12 Nobel laureates among its alumni (5) and faculty (7). There are 1,493 full time faculty in the medical school. In 2001, CWRU researchers were funded over $174,000,000 by NIH. These awards include major funding for research in cancer, AIDS, diabetes, cystic fibrosis, hypertension, TB, skin diseases, Alzheimer's disease, cartilage regeneration, airway diseases, neonatal and adult metabolism, functional electric stimulation, perinatal medicine, and genetics defects of various types among others. Fifty-seven CWRU researchers were awarded more than $1 million in NIH support in 2002. In 2002, CWRU ranked 16th among the nations 126 medical schools in NIH support. Fifteen of the school's departments ranked in the top 20 of the corresponding departments. Compared to the last five year renewal, there has been a 17% increase in the number of GCRC investigators and 81% increase in number of protocols utilizing the GCRC which resulted in a 97% increase in the number of publications (from 201). The major areas of research include: 1. Biochemical and molecular enhancement of cancer chemotherapy. 2. Electronic restoration of movement in spinal cord injury and stroke. 3. Molecular biology and treatment of cystic fibrosis. 4. Carbohydrate and protein metabolism in pregnancy. 5. Epidemiology, genetics, and pathophysiology of sleep-disordered breathing. 6. Pathophysiology and renal outcomes of human hypertension. 7. Factors affecting feto-placental growth and development. 8. Pathophysiology and treatment of HIV diseases.