LOW DOSE INHALED NITRIC OXIDE TO PREVENT CHRONIC LUNG DISEASE IN PRETERM INFANTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项多中心、随机、盲法临床试验，旨在研究低剂量吸入一氧化氮是否会增加经后36周无慢性肺部疾病的生存率，这些新生儿的出生体重为500- 1250g，在7天龄时继续需要机械通气或持续体位气道压力。该研究还将通过评估毒性和评估两岁儿童的神经发育结果来评估该疗法的安全性。注册的目标是585名4岁以上的婴儿。受试者在9-12个月矫正年龄和22-26个月矫正年龄时进行两次门诊检查，以持续评估婴儿的生长发育情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a multi-center, randomized, blinded clinical trial to investigate whether low-dose inhaled nitric oxide administered to preterm infants of 500-1250 g birth weight who continue to require mechanical ventilation or continuous position airway pressure at 7 days of age will increase survival without chronic lung disease at 36 weeks postmenstrual age. The study will also evaluate the safety of this therapy by assessing toxicity and assessing neurodevelopmental outcome through two years of age. The enrollment goal is 585 infants over 4 years. Subjects have two outpatient visits at 9-12 months corrected age and 22-26 months corrected age for ongoing evaluation of the baby's growth and development.