ALENDRONATE TO PREVENT PERIMENOPAUSAL TRANSITION BONE LOSS

描述（由申请人提供）：我们现在已经完成了四年周期中的三年。 在此期间，GCRC新项目指导团队的主要目标是解决 我们将继续努力，以弥补以往审查中发现的不足，并继续为未来制定我们的计划。我们已经完成了我们的住院部的改造，现在有一个最先进的设施， 进行临床研究。我们已将核心实验室搬迁到住院部附近的新的、更新的和方便的空间。我们提高了所有活动领域的生产力，A日和访问次数、协议数量、调查人员数量和多样性稳步增长，该单位的医学生和博士后受训人员数量增加，培训活动范围扩大。与此同时，全球化学品审查中心调查人员的出版物生产率也大幅提高。我们新的研究受试者倡导者（RSA）计划在研究受试者同意、安全性监测和法规遵从性等领域协助和教育GCRC研究人员方面发挥了重要作用。核心实验室扩大了其在基因组学和其他DNA技术的服务，我们新的运动生理学和身体成分实验室一直在为越来越多的研究人员提供服务。GCRC上的活动和兴奋程度从未如此之高。在这项竞争性的更新提案中，66名不同的主要研究人员将在几个领域执行89项方案，包括结缔组织疾病和其他疾病的遗传流行病学，药物遗传学，痴呆症研究，癌症基因表达谱，艾滋病毒自然史和发病机制，慢性疾病的运动生理学，以及代谢研究，重点是发病机制和治疗肥胖，高血压，骨质流失和糖尿病。这些补充了其他几个已经活跃的项目，包括肿瘤学和药物成瘾的精神药理学。这些领域涵盖了随着人口老龄化而出现的许多重大健康问题。我们在未来5年的重点将是继续扩大对GCRC的培训;继续扩大我们的方案多样性;并投资和扩大新的实验室和信息技术，使GCRC研究人员能够应对未来的研究挑战。为此，我们正在寻求新的资源，以扩大我们在数据库设计、基因组学能力和 运动生理学在我们这样做的同时，我们将继续以最高标准的患者护理、伦理、安全和法规遵从性进行这项研究。

DESCRIPTION (provided by applicant): We have now completed three years of a four-year cycle. The primary aim of the new program direction team of the GCRC during this time was to address shortcomings identified in previous reviews and to continue to build our program for the future. We have completed the renovation of our inpatient unit and now have a state-of-the-art facility to conduct clinical research. We have relocated our Core Laboratory to new, updated and convenient space near the inpatient unit. We have improved our productivity in all spheres of activity, with steady growth in number of A days and visits, number of protocols, number and diversity of investigators, increased number of medical students and post-doctoral trainees on the unit and expansion of the scope of training activities. This has been accompanied by a substantial increase in publication productivity by GCRC investigators. Our new Research Subject Advocate (RSA) program has played an important role in assisting and educating GCRC investigators in the areas of research subject consent, safety monitoring and regualtory compliance. The Core Laboratory expanded its services in genomics and other DNA technologies, and our new Exercise Physiology and Body Composition Laboratory has been providing services to a growing number of investigators. The level of activiy and excitement on the GCRC has never been higher. In this competing renewal proposal, 66 different principal investigators will perform 89 protocols in several areas including genetic epidemiology of connective tissue diseases and other disorders, pharmacogenetics, dementia research, gene expression profiling in cancer, HIV natural history and pathogenesis, exercise physiology in chronic diseases, and metabolic research with an emphasis on pathogenesis and treatment obesity, hypertension, bone loss and diabetes mellitus. These complement several other already active programs including oncology and psychopharmacology of drug addiction. These areas cover many of the emerging critical health issues as the population ages. Our focus over the next 5 years will be to continue to expand training on the GCRC; continue to expand our protocol diversity; and invest in and expand new laboratory and informatics technologies to allow the GCRC investigators to meet the research challenges of the future. To this end, we are requesting new resources to expand our services in database design, genomics capabilities and exercise physiology. As we do so, we will continue to perform this research with the highest standards of patient care, ethics, safety and regulatory compliance.