BIOLOGY OF OVARIAN CANCER PROGRAM PROJECT
卵巢癌生物学计划项目
基本信息
- 批准号:6334815
- 负责人:
- 金额:$ 49.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1996
- 资助国家:美国
- 起止时间:1996-04-15 至 2001-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The overall goal of the proposed project grant (PPG) is to assemble an
interdisciplinary group of talented investigators from different fields to
study the biology of ovarian cancer. The general theme of the PPG deals
with the growth aspects of ovarian tumor progression. The hypothesis to be
addressed is that the onset and progression of ovarian tumors is dependent
on aspects of growth regulation (i.e., genetic aberrations, stromal
environment, angiogenesis, and local growth facto production) that
directly influence tumor categorization, grade and stage. The present
application consists of 4 interdisciplinary individual research projects
and three core facilities. Project 1. (Michael Skinner) investigates
cell-cell interactions and ovarian cancer. The hypothesis tested is that
ovarian surface epithelial cells. (OSE) are regulated by mesenchymal
(stromal)-epithelial cell interactions mediated by the local production and
action of growth stimulators and growth inhibitors. Observations indicate
that ovarian tumor growth is dramatically influenced by the stromal
environment. The biology of normal and tumorigenic OSE will be examined.
Project 2 (Robert Jaffe) investigates angiogenesis in ovarian epithelial
carcinoma. The hypothesis tested is that the action of vascular
endothelial growth factor (VEGF) is necessary to promote the
neovascularization and tumor growth of human ovarian epithelial carcinoma.
The extent of angiogenesis and expression of VEGF will also be correlated
with tumor progression (i.e., tumor stage and grade). Project 3 (Joe Gray)
investigates the role of allelic imbalance in ovarian cancer progression.
Using analysis of loss of heterozygosity (LOH), comparative genomic
hybridization (CGH) and fluorescence in situ hybridization (FISH), the
chromosomal mapping of common allelic imbalance will be correlated with
tumor progression (i.e., tumor stage and grade). Genes will be
positionally cloned in regions of common imbalance and, in collaboration
with the other projects, genes of interest (e.g., growth factors and
receptors) will be mapped and correlated to chromosomal maps. Project 4
(Gordon Mills) investigates a recently purified ovarian cancer ascites
factor (OCAF) from ascites fluid of ovarian cancer patients and its role in
tumor growth and progression. The hypothesis tested is that OCAF produced
by ovarian cancer cells plays a role in tumorigenesis by increasing
proliferation of ovarian cancer cells, decreasing sensitivity to
chemotherapy, and altering immune responsiveness. These research
activities will be supported by the Administrative Core for the
coordination and management of the PPG. Thr Molecular Cytometry Core will
provide chromosomal mapping (i.e., LOH, CGH and FISH) and technical
assistance with FISH of tissue sections. The Tissue/Pathology Core,
directed by Bethan Powell, will collect, catalog, and prepare human ovarian
cancer surgical specimens and cell-lines for the proposed research. The
integrated activities of the four projects and investigators provides a
comprehensive examination of the biology of ovarian cancer with emphasis on
the growth aspects of tumor progression. Observations are anticipated to
provide insight into the future design of more effective therapeutic agents
for the prevention, early diagnosis and treatment of ovarian cancer.
拟议项目赠款的总体目标是,
来自不同领域的跨学科研究人员,
研究卵巢癌的生物学。 PPG交易的一般主题
与卵巢肿瘤的生长有关 假设是
卵巢肿瘤的发生和发展依赖于
关于生长调节的方面(即,遗传畸变,基质
环境、血管生成和局部生长因子 生产),
直接影响肿瘤的分类、分级和分期。 本
申请包括4个跨学科的个人研究项目
三大核心设施。 项目1。 (迈克尔斯金纳)调查
细胞间相互作用和卵巢癌。 检验的假设是,
卵巢表面上皮细胞 (OSE)是由间充质
(基质)-上皮细胞相互作用介导的本地生产和
生长刺激剂和生长抑制剂的作用。 观察表明
卵巢肿瘤的生长受到间质细胞的显著影响
环境 将检查正常和致瘤性OSE的生物学。
项目2(Robert Jaffe)研究卵巢上皮血管生成
carcinoma. 所检验的假设是,
内皮生长因子(VEGF)是促进
人卵巢上皮癌的新生血管形成和肿瘤生长。
血管生成的程度和VEGF的表达也将相关
随着肿瘤进展(即,肿瘤分期和分级)。 项目3(乔·格雷)
研究等位基因失衡在卵巢癌进展中的作用。
利用杂合性缺失(洛)分析、比较基因组学方法,
杂交(CGH)和荧光原位杂交(FISH),
常见等位基因不平衡的染色体作图将与
肿瘤进展(即,肿瘤分期和分级)。 基因会
在共同不平衡的区域进行位置克隆,
对于其他项目,感兴趣的基因(例如,生长因子和
受体)将被绘制并与染色体图谱相关联。 项目4
(戈登米尔斯)调查最近纯化的卵巢癌腹水
卵巢癌患者腹水中OCAF的表达及其在卵巢癌治疗中的作用
肿瘤生长和进展。 测试的假设是,OCAF产生
卵巢癌细胞在肿瘤发生中起作用,
卵巢癌细胞的增殖,降低对
化疗和改变免疫反应。 这些研究
活动将得到行政核心的支持,
PPG的协调和管理。 分子细胞计数核心将
提供染色体作图(即,洛缺失、CGH和FISH)和技术
协助组织切片的FISH。 组织/病理学核心,
由Bethan Powell指导,将收集,分类,并准备人类卵巢
癌症手术标本和细胞系用于拟议的研究。 的
四个项目和调查人员的综合活动提供了一个
卵巢癌的生物学的全面检查,重点是
肿瘤进展的生长方面。 预计观察结果将
为未来设计更有效的治疗药物提供了见解
用于卵巢癌的预防、早期诊断和治疗。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERT B JAFFE其他文献
ROBERT B JAFFE的其他文献
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{{ truncateString('ROBERT B JAFFE', 18)}}的其他基金
ALENDRONATE TO PREVENT PERIMENOPAUSAL TRANSITION BONE LOSS
阿仑膦酸钠预防围绝经期骨质流失
- 批准号:
7202641 - 财政年份:2005
- 资助金额:
$ 49.08万 - 项目类别:
Alendronate to Prevent Perimenopausal Transition Bone Loss
阿仑膦酸钠预防围绝经期骨质流失
- 批准号:
6972300 - 财政年份:2004
- 资助金额:
$ 49.08万 - 项目类别:
PITUITARY-OVARIAN RESPONSES TO GNRH AGONIST TESTING IN WOMEN W/POLYCYSTIC OVARY
多囊卵巢女性对 GNRH 激动剂测试的垂体-卵巢反应
- 批准号:
6246360 - 财政年份:1997
- 资助金额:
$ 49.08万 - 项目类别:
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