Stability of dry powder formulations used in drug delivery to the lungs studied one particle at a time

一次研究一个颗粒用于肺部药物输送的干粉制剂的稳定性

• 批准号: 2886523
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2886523
• 关键词: Stability; dry; powder; formulations; used

The PhD project will involve the use of a range of conventional tools for characterising formulation performance and stability along with novel single aerosol particle tools developed at the University of Bristol. The specific objectives of the PhD will be to:1. Develop a range of test formulations that exhibit different stability behaviours, characterised by their fine particle aerodynamic performance.2. Assess how changes in storage conditions of the inhalers within a closed secondary pack (e.g., foil overwrap) affect the rate of change.3. Quantify how changes in particulate properties at the microscale may be implicated in these macro level changes.4. Develop models for predicting magnitude of changes over shelf-life.5. Suggest manufacturing control strategy to manage instability.

博士项目将涉及使用一系列传统工具来表征配方性能和稳定性，以及布里斯托尔大学开发的新型单一气溶胶颗粒工具。博士学位的具体目标是：1。开发一系列具有不同稳定性行为的测试配方，其特点是其细颗粒空气动力学性能。评估吸入器在封闭的二次包装（如铝箔包）中的储存条件的变化如何影响变化的速率。量化微粒性质在微观尺度上的变化如何影响这些宏观水平的变化。开发模型来预测保质期内的变化幅度。提出制造控制策略以控制不稳定性。