Stability of dry powder formulations used in drug delivery to the lungs studied one particle at a time

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The PhD project will involve the use of a range of conventional tools for characterising formulation performance and stability along with novel single aerosol particle tools developed at the University of Bristol. The specific objectives of the PhD will be to:1. Develop a range of test formulations that exhibit different stability behaviours, characterised by their fine particle aerodynamic performance.2. Assess how changes in storage conditions of the inhalers within a closed secondary pack (e.g., foil overwrap) affect the rate of change.3. Quantify how changes in particulate properties at the microscale may be implicated in these macro level changes.4. Develop models for predicting magnitude of changes over shelf-life.5. Suggest manufacturing control strategy to manage instability.