Using atomic force microscopy to explore the processes and re-organisations that occur during bacterial growth and division and how these are influenc

使用原子力显微镜探索细菌生长和分裂过程中发生的过程和重组以及它们如何影响细菌

• 批准号: 2887441
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2887441
• 关键词: Using; atomic; force; microscopy; explore

Atomic force microscopy and related scanning probe techniques will be used to study the architecture of the bacterial cell wall. How the cell wall evolves during growth and division will be studied by direct imaging during growth and through study of extracted cell walls. Complementary automated image analysis approaches will be developed and applied to quantify the images obtained. How these processes are interrupted by antibiotic action, and how the processes are modified in resistance, will also be explored.

原子力显微镜和相关的扫描探针技术将用于研究细菌细胞壁的结构。细胞壁在生长和分裂期间如何演变将通过在生长期间直接成像和通过研究提取的细胞壁来研究。将开发和应用补充的自动图像分析方法来量化所获得的图像。这些过程是如何被抗生素作用中断的，以及这些过程是如何在抗性中被修改的，也将被探讨。