Management of Brain Tumor Treatment with Tumor Morphometrics in Magnetic Resonanc

磁共振肿瘤形态计量学脑肿瘤治疗管理

• 批准号: 7272506
• 负责人: James Reuss
• 金额: $ 20.06万
• 依托单位: PRISM CLINICAL IMAGING INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2010-03-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7272506
• 关键词: Accounting; Administrator; Adoption; Advertising; Affect; Algorithms; American; American Cancer Society; American College of Radiology; Angiography; Area; Award; Awareness; Brain; Brain Neoplasms; Brain imaging; Brain scan; Businesses; Cardiovascular system; Class; Clinical; Clinical Treatment; Communication; Communities; Compatible; Competence; Computer software; Cost Analysis; Current Procedural Terminology Codes; Data; Data Collection; Decision Making; Dementia; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Imaging; Doctor of Philosophy; Equipment; Europe; Evaluation; Fees; Foundations; Goals; Grant; Growth; Guidelines; Health Insurance; Healthcare; Image; Imagery; Imaging Techniques; Incidence; Individual; Industry; Institution; Intellectual Property; Intelligence; International; Interobserver Variability; Intraobserver Variability; Laws; Leadership; Legal patent; Licensing; Life; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetism; Malignant Neoplasms; Malignant neoplasm of brain; Manuals; Manufacturer Name; Marketing; Measurement; Measures; Medical; Medical Device; Medical Imaging; Medical Surveillance; Medicare; Medicine; Methods; Metric; Names; National Cancer Institute; Nervous system structure; Neurology; Neurosurgeon; North America; Notification; Numbers; Oncologist; Pamphlets; Paper; Patients; Penetration; Perfusion; Periodicals; Phase; Physicians; Physiological; Press Releases; Prevalence; Price; Printing; Procedures; Process; Protocols documentation; Qualifying; Radiation Oncologist; Radiology Specialty; Rate; Reader; Registries; Reproducibility; Research; Research Personnel; Sales; Scanning; Services; Simulate; Slice; Societies; Source; Standardization; Standards of Weights and Measures; Surface; System; Techniques; Testing; Tetradecanoylphorbol Acetate; Therapeutic; Therapeutic Radiology specialty; Time; Trademark; Translating; Tumor Volume; United States; United States Food and Drug Administration; Variant; Vendor; Visit; Weight; Wisconsin; Woman; Work; Workload; World Health Organization; base; cohort; college; cost; day; design; experience; improved; innovation; interest; men; neuro-oncology; oncology; outreach; programs; radiologist; research clinical testing; size; tool; tumor; tumor growth

DESCRIPTION (provided by applicant): Radiology has traditionally relied upon qualitative assessment of tumor growth to guide therapeutic decision-making. The adoption of quantitative techniques such as WHO and RECIST guidelines in radiology has been slow due to multiple factors, including the workload and inter-operator variability associated with manual measurement, the complexity and pitfalls of automated techniques, and the many inherent sources of variability in medical imaging making longitudinal comparison difficult. We will develop, design and evaluate a semi- automated morphometrics system for quantification of tumors in the brain. The input to our system will be multiple images from magnetic resonance imaging (MRI) systems, particularly post-contrast T1 studies. The final product will be a modular extension to our FDA-cleared Prism View(tm) software package, compatible with MRI systems currently used for brain imaging. We will demonstrate feasibility in Phase I by developing means for geometrical registration and intensity standardization in imaging protocols, collecting data to document intra-patient and intra- and inter-reader variability, and evaluating our system in a study of a small number of subjects. In Phase II, we will further refine algorithms based upon Phase I findings and evaluate our system in a much larger cohort of subjects to more rigorously evaluate accuracy and precision in sizing of tumors. If successful, greater confidence will be achieved in following tumor changes over time, and this should translate into more rapid understanding of the efficacy of medical treatment or management of brain tumors. Our focus is on 2D and 3D tumor geometry, not on tumor composition. However, the existing product line (Prism) already facilitates combination and viewing of functional and physiologic information including MR spectroscopy and MR perfusion studies, and this information will be readily superposed upon the regions of interest delineated in anatomical imagery.

描述(由申请人提供)：放射学传统上依赖对肿瘤生长的定性评估来指导治疗决策。由于多种因素，如WHO和RECIST指南等定量技术在放射学中的采用缓慢，包括与手动测量相关的工作量和操作员间的可变性，自动化技术的复杂性和缺陷，以及医学成像中许多固有的可变性来源，使得纵向比较变得困难。我们将开发、设计和评估一个用于脑肿瘤量化的半自动形态测量系统。我们系统的输入将是来自磁共振成像(MRI)系统的多幅图像，特别是增强后T1研究。最终产品将是我们获得FDA批准的Prism View(Tm)软件包的模块化扩展，与目前用于脑成像的MRI系统兼容。在第一阶段，我们将通过开发成像协议中几何配准和强度标准化的方法，收集数据来记录患者内部、读者内部和读者之间的可变性，并在少数受试者的研究中评估我们的系统，从而证明其可行性。在第二阶段，我们将根据第一阶段的发现进一步改进算法，并在更大的受试者队列中评估我们的系统，以更严格地评估肿瘤大小的准确性和精确度。如果成功，随着时间的推移，将获得更大的信心来跟踪肿瘤的变化，这应该会转化为更快地了解脑肿瘤的药物治疗或管理的有效性。我们的重点是2D和3D肿瘤几何形状，而不是肿瘤成分。然而，现有的产品线(棱镜)已经促进了功能和生理信息的组合和查看，包括磁共振波谱和磁共振血流灌注研究，并且这些信息将很容易地叠加在解剖图像中描绘的感兴趣区域上。