Advanced Visualization Techniques for Functional Imagery in Neurodevice Surgical

神经设备手术中功能图像的高级可视化技术

• 批准号: 7480752
• 负责人: James Reuss
• 金额: $ 17.38万
• 依托单位: PRISM CLINICAL IMAGING INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7480752
• 关键词: Accounting; Administrator; Advertising; Affect; American; American College of Radiology; Angiography; Award; Awareness; Boston; Brain; Brain Injuries; Brain imaging; Brain scan; Broca Aphasia; Businesses; Class; Clinic; Clinical; Clinical Treatment; Clinical Trials; Communication; Communities; Compatible; Competence; Computer software; Condition; Conscious; Cost Analysis; Costs and Benefits; Current Procedural Terminology Codes; Data; Data Collection; Deep Brain Stimulation; Dementia; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Doctor of Philosophy; Dystonia; Electric Stimulation; Electrodes; Electrophysiology (science); Epilepsy; Equipment; Essential Tremor; Europe; Evaluation; Fees; Foundations; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Grant; Growth; Health Benefit; Health Insurance; Healthcare; Hospitals; Image; Imagery; Imaging Techniques; Industry; Institution; Intellectual Property; Intelligence; International; Internet; Invasive; Laws; Leadership; Legal patent; Licensing; Location; Magnetic Resonance; Magnetic Resonance Imaging; Magnetoencephalography; Manufacturer Name; Maps; Marketing; Medical; Medical Device; Medical Imaging; Medicare; Medicine; Mental Depression; Mental disorders; Metabolism; Methodology; Methods; Modeling; Motor; Multimodal Imaging; Names; Navigation System; Nerve; Neurology; Neuronavigation; Neurosciences; Neurostimulation procedures of spinal cord tissue; Neurosurgeon; North America; Notification; Numbers; Obsessive-Compulsive Disorder; Online Systems; Operative Surgical Procedures; Pain; Pamphlets; Paper; Parkinson Disease; Patients; Penetration; Periodicals; Peripheral Nerve Stimulation; Phase; Physicians; Physiological; Placement; Planning Techniques; Positioning Attribute; Postoperative Period; Press Releases; Price; Principal Investigator; Printing; Procedures; Process; Professional Meetings and Conferences; Program Evaluation; Qualifying; Radiology Specialty; Range; Rate; Rehabilitation therapy; Research; Risk; Saint Jude Children' s Research Hospital; Sales; Signal Transduction; Site; Societies; Software Tools; Source; Standards of Weights and Measures; Surface; System; Techniques; Technology; Testing; Tetradecanoylphorbol Acetate; Time; Tinnitus; Trademark; Transcranial magnetic stimulation; Translating; United States; United States Food and Drug Administration; Vendor; Visit; Weight; Wisconsin; Work; X-Ray Computed Tomography; base; chronic pain; cohort; college; cost; data modeling; design; experience; follow-up; implantation; improved; innovation; interest; nervous system disorder; neuroimaging; neuropsychiatry; neurosurgery; neurotechnology; outreach; post stroke; programs; radiologist; response; symposium; tool; tumor; vagus nerve stimulation; virtual

DESCRIPTION (provided by applicant): Neurodevices are finding application in many neurological disorders, offering hope in situations where conventional non-surgical treatments are ineffective or unavailable. Surgical procedures often involve intraoperative determination of optimal electrode placement, a lengthy undertaking often requiring trial- and-error evaluation of potential sites with a conscious, cooperative patient. Recent interest in the application of functional imaging, including functional magnetic resonance imaging (fMRI), to this problem has produced promising results. We will develop, design and evaluate a neurodevice pre- surgical planning and follow-up system utilizing functional imaging intended to assist in cortical electrode placement. The input to our system will be multiple images from computed tomography (CT) and magnetic resonance imaging (MRI) systems, particularly functional magnetic resonance imaging (fMRI) studies. The final product will be a modular extension to our FDA-cleared Prism View} software package, compatible with MRI systems currently used for brain imaging. We will demonstrate feasibility in Phase I by developing means for visualizing functional, physiologic and anatomical data in a fashion particularly suitable to planning cortical electrode placement and visualizing post-surgical results. We will be, and evaluating our system in a study of a small number of subjects. In Phase II, we will further refine our software tools, possibly expanding their application for other neurodevices; investigate additional features such as field modeling of stimulators; and evaluate our system in a larger cohort of subjects to more rigorously evaluate accuracy and precision in predicting optimal electrode placement. Greater confidence will be achieved in utilizing pre-surgical functional imaging to reduce the need for intraoperative electrophysiological testing, and this should translate to reduced operative times. Our initial focus is on applications involving fMRI and epidural cortical electrodes. However, it is expected that the technology will also be applicable to functional imaging by transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG); implantation of deep brain stimulation (DBS) devices; and ultimately modeling of stimulator field effects to support virtual neurodevice evaluation. We will develop, design and evaluate a pre-surgical planning and post-surgical follow-up system for neurodevice applications utilizing functional imaging. Our initial target application applies functional magnetic resonance imaging to cortical electrode placement. If successful, potential health benefits of this system include reduced operative time for neurodevice installation, increasing patient comfort and reducing risk; improved device functionality due to better electrode placement. Cost benefits are associated with reduced operative time.

描述（由申请人提供）：神经器械在许多神经系统疾病中得到应用，在传统非手术治疗无效或不可用的情况下提供了希望。外科手术通常涉及术中确定最佳电极放置，这是一项漫长的工作，通常需要在有意识、合作的患者的情况下对潜在部位进行试错评估。最近的兴趣，包括功能性磁共振成像（fMRI）的应用，这个问题已经产生了可喜的成果。我们将开发、设计和评价一种神经器械术前计划和随访系统，该系统利用功能成像来辅助皮质电极放置。我们系统的输入将是来自计算机断层扫描（CT）和磁共振成像（MRI）系统的多个图像，特别是功能性磁共振成像（fMRI）研究。最终产品将是FDA批准的Prism View软件包的模块化扩展，与目前用于脑成像的MRI系统兼容。我们将通过开发一种特别适合于规划皮质电极放置和可视化术后结果的方式来可视化功能、生理和解剖数据的方法来证明第一阶段的可行性。我们将在对少数受试者的研究中评估我们的系统。在第二阶段，我们将进一步完善我们的软件工具，可能将其应用扩展到其他神经设备;研究其他功能，如刺激器的场建模;并在更大的受试者队列中评估我们的系统，以更严格地评估预测最佳电极放置的准确性和精确度。利用术前功能成像将获得更大的信心，以减少术中电生理测试的需要，这应该转化为减少手术时间。我们最初的重点是涉及功能磁共振成像和硬膜外皮质电极的应用。然而，预计该技术也将适用于经颅磁刺激（TMS）和脑磁图（MEG）功能成像;脑深部电刺激（DBS）器械植入;以及最终模拟刺激器场效应以支持虚拟神经器械评价。我们将开发、设计和评估一个术前规划和术后随访系统，用于利用功能成像的神经器械应用。我们最初的目标应用程序将功能磁共振成像应用于皮层电极放置。如果成功，该系统的潜在健康益处包括减少神经器械安装的手术时间，增加患者舒适度并降低风险;由于更好的电极放置而改善器械功能。成本效益与手术时间缩短有关。