Development of new elastic titanium immediate load implants

描述（由申请人提供）：优化其在口腔颌面应用中的性能。最近的研究已经确定了一类新的钛材料，其机械强度和弹性远远优于当前的商业钛系统。本研究的目的是开发用于立即负载应用的强且高弹性的可植入材料。该研究将解决新型钛合金的两个重要问题，即最大限度地提高弹性和机械强度，并实现高速率骨整合和长期生物相容性。第I阶段有两个具体目标：1）确定一种在表面产生多孔性和高钛含量的新方法，2）证明理想的表面形态和生物相容性，以实现更好的骨整合。通过纳米技术原理设计的两种特定表面处理将被证明是建立其作为未来即时负载系统的关键优势。具有最高弹性的新型钛合金的最佳合金/表面系统将用于在II期研究中开发临床创新材料。第二阶段将致力于从材料合成、植入器械设计、表面处理到体内植入物载荷评估的新型植入合金的综合开发。这些新的钛合金将有潜力改善现有的牙科和颌面修复体的钛合金系统，因为它与骨的弹性更好地匹配。更大的应用将是开发更小更薄的植入物组件和修复体，可以承受沉重的咀嚼功能。商业应用有望将牙科植入物扩展到骨结构较差的普通人群的下一个水平，如果证明可靠和高性能的钛生物材料，最终将扩展到大尺寸关节和骨段。

DESCRIPTION (provided by applicant): optimize their performance for oral and maxillofacial applications. Recent research has identified a new class of titanium materials with far better mechanical strength and elasticity than the current commercial titanium systems. The purpose of this research is to develop strong and highly elastic implantable materials for immediate load applications. The research will address two significant issues for the new titanium alloys, namely, to maximize elasticity with mechanical strength, and achieve high-rate osseointegration with long-term biocompatibility. Phase I has two Specific Aims: 1) identify a novel approach to create porosity and high Ti-content at the surface, and 2) demonstrate desirable surface morphology and biocompatibility for better osseointegration. Two specific surface treatments designed through nanotechnology principles will be demonstrated for establishing their key benefits as future immediate load systems. The best alloy/surface system with the highest elasticity of the new titanium alloys will be used to develop clinically innovative materials in the Phase II research. Phase II will pursue an integrated development of new implantable alloys from material synthesis, implant device designs, surface treatment to in-vivo implant loading evaluation. These new Ti alloys will have the potential to improve current titanium alloy systems for Dental and maxillofacial prostheses because it matches the elasticity of bone better. Greater applications will be in developing smaller and thinner implant components and prostheses that can withstand heavy masticatory functions. Commercial applications are expected to broaden Dental implant to the next level of general population with poor bone structures, and eventually extend to large-size joint and bone segments if reliable and high performance titanium biomaterials are demonstrated.