Within-host drivers of zoonotic disease dynamics

个体是一组不同的有机体的宿主，包括蠕虫、原生动物、细菌和病毒的寄生虫群落，但每个组成部分如何相互作用尚不清楚。我们认为，每个主机内组件都会随着主机内驱动程序的变化而变化，但也会随着环境的变化而变化。相互作用的后果是重要的，特别是如果我们考虑到人畜共患寄生虫和病原体是相互作用系统的一部分。当宿主数量和相互作用可以迅速和戏剧性地改变(例如，在环境恢复野生或宿主的药物治疗期间)时，宿主内部动态平衡的变化尤其重要(也是未知的)。在这里，我们将重点了解环境变化对农业生态系统中宿主内寄生虫相互作用的交叉影响，包括野生动物宿主和作为人畜共患病宿主的牲畜；后者是因为它们受到寄生虫/病原体的处理，自然扰乱寄生虫群落。我们将对宿主微生物区系、真核基因组和病毒体进行采样，以了解寄生虫群落的波动如何影响人畜共患病病原体(导致人类疾病的动物病原体)的流行以及随后对公共卫生的风险

Individuals are host to a diverse set of organisms, including parasite communities of helminths, protozoa, bacteria, and viruses, but how each component interacts is unclear. We propose that each within-host component fluctuates in response to within-host drivers, but also to changes in the environment. The consequences of interaction are important, especially if we consider that zoonotic parasites and pathogens are part of that interacting system. Changes in within-host homeostasis is particularly important (and unknown) when host numbers and interactions can change rapidly and dramatically (for example, during rewilding of the environment or drug treatment of a host). Here, we will focus on understanding the intersection of environmental changes on within-host parasite interactions in agroecosystems including wildlife hosts and livestock as reservoirs of zoonoses; the latter because they are subject to parasite/pathogen treatments that naturally perturb the parasite community. We will sample host microbiota, eurkaryome and virome to understand how parasite community fluctuations affects the prevalence of zoonotic pathogens (animal pathogens causing disease in humans) and the subsequent risk to public healt