Behavioral Rx & Nutrition in Pediatric Chronic Disease

描述（由申请人提供）： 本次更新以患者为导向的研究中期研究者奖的具体目的是：1）促进候选人在行为干预方面的研究，以提高囊性纤维化和学龄前肥胖幼儿的饮食依从性和健康结果，和2）为候选人提供受保护的时间和资源，以指导正在进行临床研究的心理学和儿科学的初级教师和博士后研究员儿童行为营养干预的职业生涯。候选人的计划性研究集中在检查影响慢性病儿童饮食依从性的行为因素。在每一种疾病中，目标都是制定行为干预措施，在严格的临床试验中测试干预措施，并将有效的研究干预措施转化为临床实践。她以前对囊性纤维化学龄儿童的研究实现了这些目标，因为它直接导致将行为评估和治疗纳入CF学龄儿童的临床护理建议。这项工作也直接导致了目前的R 01，她是一名共同研究者，将行为干预的应用扩展到患有CF的学龄前儿童。候选人在钙的行为饮食干预方面的研究在改善青少年类风湿性关节炎和炎症性肠病儿童的钙摄入和骨增生方面同样有效。候选人还拥有初级教师和博士后研究员导师的既定记录，其中75%的学员在她之前的K24奖项期间获得了NIH资助。该研究计划包括两个项目：NIH/NIDDK竞争性延续R 01临床试验，“帮助CF学龄前儿童成长的行为和营养治疗”，以及一项新的干预研究，重点关注学龄前肥胖的治疗。早期职业教师和博士后研究员的指导计划将包括：1）4名初级教师的个性化指导，其中一名将是在学龄前肥胖领域撰写K23的儿科医生，3名心理学家从K23过渡到R奖项; 2）患者的强化实践培训-在K24目前研究项目的背景下，为NIDDK T32培训补助金的2名研究员进行定向研究，以及开发他们自己的独立研究项目，以及3）博士后研究员参与已建立的关于手稿和资助写作、临床试验和临床研究方法的设计以及临床研究中的伦理学的教学计划。辛辛那提儿童医院医疗中心提供了一个理想的环境，因为该中心致力于以患者为导向的研究，强大的儿科综合临床研究中心的存在，并正在进行的举措，以促进创新的临床研究，包括GCRC的行为核心和儿童行为和营养研究（T32）的跨学科培训补助金。

DESCRIPTION (provided by applicant): The Specific Aims of this renewal of a Midcareer Investigator Award in Patient-Oriented Research are 1) to further the candidate's research in behavioral interventions for enhancing dietary adherence and health outcomes in young children with cystic fibrosis and preschool obesity, and 2) to provided the candidate protected time and resources to mentor junior faculty and postdoctoral fellows in psychology and pediatrics who are pursuing clinical research careers in behavioral nutrition interventions for children. The Candidate's programmatic research has focused on examining behavioral factors that affect dietary adherence in children with chronic conditions. In each disorder the aim has been to develop behavioral interventions, test the interventions in rigorous clinical trials, and translate efficacious research interventions into clinical practice. Her previous work with school age children with cystic fibrosis achieved these goals as it directly led to incorporation of behavioral assessment and treatment into recommendations for clinical care of school age children with CF. This work also directly led to a current R01, on which she is a Co Investigator, to extend the application of the behavioral intervention to preschool children with CF. The candidate's research in behavioral dietary interventions for calcium has been equally effective in improving the calcium intake and bone accretion in children with juvenile rheumatoid arthritis and inflammatory bowel disease. The candidate also has an established track record of mentorship of junior faculty and postdoctoral fellows in which 75% of her mentees received NIH funding during the period of her previous K24 award. The Research Plan includes two projects: an NIH/NIDDK competing continuation R01 clinical trial, "Behavioral & Nutrition Treatment to Help CF Preschoolers Grow," and a new intervention study focused on treatment of preschool obesity. The Mentoring Plan for early career faculty and postdoctoral fellows will consist of: 1) individualized mentoring of 4 junior faculty, one will be a pediatrician writing a K23 in the area of preschool obesity and 3 psychologists transitioning from K23s to R awards; 2) intensive practical training in patient-oriented research within the context of the current research projects of the K24 for 2 fellows on the NIDDK T32 training grant, as well as development of their own independent research projects, and 3) participation of postdoctoral fellows in established didactic programs on manuscript and grant writing, design of clinical trials and clinical research methodology, and ethics in clinical research. Cincinnati Children's Hospital Medical Center provides an ideal setting for continuation of this award because of the commitment to patient-oriented research, the presence of a strong pediatric General Clinical Research Center, and ongoing initiatives to promote innovative clinical research including the Behavioral Core of the GCRC and the interdisciplinary training grant in Child Behavior and Nutrition Research (T32).