DIETARY CALCIUM/BEHAVIORAL INTEVENTION IN CHILDREN WITH JRA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。患有JRA的儿童在成年早期存在低骨量和骨折的风险。本项目比较了行为干预计划（BI）和强化标准护理条件（ESC）在增加JRA儿童膳食钙摄入量和骨量方面的作用。该项目评估干预前后（大约8周后）的膳食钙摄入量，并在2年内每隔6个月评估一次。骨量也在基线和治疗后2年每6个月检查一次。假设接受BI治疗的JRA儿童每天的膳食钙摄入量明显高于接受ESC治疗前后（8周）的JRA儿童。我们还假设BI组钙摄入量的增加在治疗后24个月内将保持不变，并且BI组的钙摄入量将显著大于ESC组。最后，假设BI状况将导致骨量比ESC明显更大的增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children with JRA are at risk for low bone mass and fracture in early adulthood. The present project compares a Behavior Intervention Program (BI) to an enhanced standard of care condition (ESC) for increasing dietary calcium intake and bone mass in children with JRA. The program evaluates dietary calcium intake pre to post intervention (approximately 8 weeks later) and at 6 month intervals over 2 years. Bone mass is also examined at baseline and at 6 month intervals for 2 years post treatment. It is hypothesized that children with JRA receiving the BI will have a significantly greater dietary calcium intake per day than children with JRA receiving ESC pre to post treatment (8 weeks). It is also hypothesized that the increased calcium intake of the BI group will be maintained across 24 months post treatment and that the calcium intake of the BI group will be significantly greater than the ESC group. Finally, it is hypothesized that the BI condition will result in a significantly greater increase in bone mass than the ESC.