Alzheimer's Disease Research Center

描述(由申请人提供)：华盛顿大学阿尔茨海默病研究中心(ADRC)的总体目标是继续支持和加强一个互动的多学科中心环境，使正在进行的研究项目和新的研究计划能够解决阿尔茨海默病(AD)和其他神经退行性痴呆的发病机制、病理生理学和治疗。一个由基础和临床研究人员、医疗保健专业人员和管理人员组成的跨学科协作团队已经在华盛顿大学联合起来，支持和实施一系列富有成效的痴呆症项目。主要的重点是解决阿尔茨海默病和其他痴呆障碍的遗传学问题：其他研究工作涉及阿尔茨海默病和正常衰老的神经内分泌学和神经化学，以及阿尔茨海默病的药物和行为治疗。ADRC通过直接合作和正式的多中心项目，如国家阿尔茨海默氏症协调中心(NACC)、阿尔茨海默病合作研究(ADCS)、新整合的UW ADRC/俄勒冈健康与科学大学ADC神经病理学核心，以及晚发性家族性AD的多站点NIA遗传学计划，支持和促进ADRC内部、大华盛顿大学研究界和全国范围内的生产性研究。ADRC创造了一个职业发展环境，研究员和初级教员在这个环境中获得研究和临床技能以及在跨学科AD研究环境中工作的经验。前一个资助期的成就涵盖了对AD知识的广泛的基础、临床和行为贡献。目前的申请要求延续七个ADRC核心，并提出三个研究项目。两个项目延续了我们关于AD遗传学的富有成效的计划主题：第一个项目使用定量性状连锁分析来寻找晚发性AD的易感基因；第二个项目将确定由AD引起的早老素-2突变的发病年龄的修饰因素。第三个项目将利用UW ADRC CSF和脑库，并应用蛋白质组学来解决痴呆症诊断和监测疾病进展的生物标记物的需求。

DESCRIPTION (provided by applicant): The overall goal of the University of Washington (UW) Alzheimer's Disease Research Center (ADRC) is to continue to support and enhance an interactive multidisciplinary center milieu that enables ongoing research projects and new research initiatives addressing the pathogenesis, pathophysiology, and treatment of Alzheimer's disease (AD) and other neurodegenerative dementing disorders. An interdisciplinary collaborative team of basic and clinical investigators, health care professionals, and administrative personnel has coalesced at the UW to support and carry out an array of productive dementia programs. Primary emphasis has been directed at projects addressing the genetics of AD and other dementing disorders: other research efforts have addressed neuroendocrinology and neurochemistry of AD and normal aging, and both pharmacologic and behavioral treatments of AD. The ADRC supports and fosters productive research within the ADRC, in the greater UW research community and nationally through direct collaborations and formal multi-center programs such as the National Alzheimer's Coordinating Center (NACC), the Alzheimer's Disease Cooperative Study (ADCS), the newly integrated UW ADRC/Oregon Health and Science University ADC Neuropathology Core, and the multisite NIA genetics of late-onset familial AD initiative. The ADRC has created a career development environment in which fellows and junior faculty acquire research and clinical skills and experience working in an interdisciplinary AD research setting. Accomplishments of the previous funding period have covered a broad spectrum of basic, clinical and behavioral contributions to knowledge about AD. The current application requests continuation of seven ADRC cores and proposes three research projects. Two projects continue our productive programmatic theme of the genetics of AD: the first uses quantitative trait linkage analysis to find susceptibility genes for late onset AD; the second will identify modifiers of age of onset of presenilin-2 mutation caused AD. The third project will utilize the UW ADRC CSF and brain banks and apply proteomics to address the need for biomarkers for dementia diagnosis and monitoring disease progression.