Alzheimer's Disease Research Center

描述(由申请人提供)：华盛顿大学阿尔茨海默病研究中心(ADRC)的总体目标是继续提供一个研究环境，促进获得关于AD和相关神经退行性痴呆的病理生物学的新知识，并将这些知识应用于实验疗法的开发。由基础和临床研究人员、医疗保健专业人员和行政人员组成的跨学科协作团队支持和执行一系列富有成效的痴呆症研究和职业发展计划。尽管ADRC的附属研究将继续处理AD和其他痴呆障碍的遗传学问题，但ADRC的主题已重新聚焦于生物标记物和实验疗法。ADRC通过直接合作和正式的多中心项目，如国家阿尔茨海默氏症协调中心(NACC)、阿尔茨海默病合作研究(ADCS)、综合UW ADRC/俄勒冈健康与科学大学ADC神经病理学核心和NIA晚发性家族性AD遗传学倡议，支持ADRC内部、大华盛顿大学研究界和全国范围内的生产性研究。研究员和初级教员在其中获得研究和临床技能的职业发展环境得到了富有成效的试点资助计划的支持。以往的成就为人们对AD的认识做出了基础、临床和行为方面的贡献。ADRC提出了五个ADRC核心和三个研究项目：项目1：药物诱导的中枢神经系统胰岛素活性增加的脑脊液结合图谱，Thomas J.Montle博士；项目2：鼻腔Insulin detemir的治疗效果，Suzanne Craft博士；项目3：成人骨髓移植体内A？肽积累和神经元损伤的调节，C.Dirk Keene博士。

DESCRIPTION (provided by applicant): The overall goal of the University of Washington (UW) Alzheimer's Disease Research Center (ADRC) is to continue to provide a research milieu that facilitates the acquisition of new knowledge about the pathobiology of AD and related neurodegenerative dementing disorders and applies this knowledge to the development of experimental therapeutics. An interdisciplinary collaborative team of basic and clinical investigators, health care professionals, and administrative personnel supports and carries out an array of productive dementia research and career development programs. Although ADRC affiliated research addressing the genetics of AD and other dementing disorders will continue, the ADRC theme has refocused on biomarkers and experimental therapeutics. The ADRC supports productive research within the ADRC, in the greater UW research community and nationally through direct collaborations and formal multi-center programs such as the National Alzheimer's Coordinating Center (NACC), the Alzheimer's Disease Cooperative Study (ADCS), the integrated UW ADRC/Oregon Health and Science University ADC Neuropathology Core, and the NIA genetics of late-onset familial AD initiative. A career development environment in which fellows and junior faculty acquire research and clinical skills is supported by a productive pilot grant program. Previous accomplishments have generated basic, clinical and behavioral contributions to knowledge about AD. The ADRC proposes five ADRC cores and three research projects: Project 1: CSF binding profiling of drug- induced increased CNS insulin activity, Dr. Thomas J. Montine; Project 2: Therapeutic Effects of Intra-Nasal Insulin Detemir, Dr. Suzanne Craft; Project 3: Modulation of A¿ peptide accumulation and neuron damage in vivo with adult bone marrow transplants, Dr. C. Dirk Keene.