MOUSE BEHAVIOR AND NEUROPATHOLOGY CORE

预计ADRC的一些研究人员将参与或希望参与阿尔茨海默病遗传操纵小鼠模型的行为和/或组织病理学研究。小鼠行为和神经病理学(MBN)核心是ADRC设计和执行此类研究的中心核心，利用MBN核心的设备和专业知识。因此，MBN核心的主要职能将是使其他PI及其实验室人员熟悉行为/组织病理学数据的收集和分析，并在解释所获得的结果方面提供专业知识。具体地说，MBN核心将1)设计和进行遗传操纵的行为/组织病理学研究 涉及MBN核心人员的AD小鼠模型2)协助其他ADRC研究人员 设计和实施与他们正在解决的研究问题相关的小鼠行为/组织病理学研究3)为ADRC研究人员和那些利用ADRC资源的研究人员提供行为和组织病理学方法方面的培训和咨询，以便他们可以将这些方法纳入他们的研究并在MBN核心设施内独立使用这些方法，以及4)从在MBN核心内执行的项目和研究中向数据管理、生物统计和流行病学(DMBE)核心提供行为和组织病理学数据。然后，DMBE将存储/分析这些数据，确定任何给定研究中行为和组织病理学数据之间的任何相关性/相互关系，并提供MBN数据(例如，项目3)和 从相关的临床项目(例如，项目2)中获得的。根据ADRC的建议，该中心的工作对于研究阿尔茨海默病的机制、遗传学、风险因素和治疗方法是绝对必要的。

It is expected that a number of researchers in the ADRC will be involved with, or wish to become involved with, behavioral and/or histopathologic studies in genetically-manipulated mouse models for AD. The Mouse Behavior and Neuropathology (MBN) core is the central core through which such studies will be designed and performed at the ADRC, utilizing equipment and expertise of the MBN Core. Thus, the main function of the MBN Core will be to acquaint other Pi's and their laboratory personnel with the collection and analysis of behavioral/histopathologic data, as well as provide expertise in the interpretation of results obtained. Specifically, the MBN Core will 1) design and carry out behavioral/histopathologic studies in geneticallymanipulated mouse models of AD that involve MBN Core personnel 2) assist other ADRC researchers in designing and carrying out mouse behavioral/histopathologic studies that relate to the research questions they are addressing 3) provide training and consultation in behavioral and histopathologic methodologies to ADRC researchers, and those utilizing ADRC resources, so that they may incorporate such methodologies into their research and utilize these methodologies independently within the MBN Core facilities, and 4) provide behavioral and histopathologic data to the Data Management, Biostatistics, and Epidemiology (DMBE) Core from projects and studies performed within the MBN Core. The DMBE will then store/analyze these data, determine any correlations/inter-relationships between behavioral and histopathologic data in any given study, and provide any interfacing statistical analyses between MBN data (e.g., Project #3) and that attained from related clinical projects (e.g., Project #2). The work of this Core is absolutely essential for investigating Alzheimer's disease mechanisms, genetics, risk factors and treatments in the context of this ADRC proposal.