MOUSE BEHAVIOR AND NEUROPATHOLOGY CORE

预计ADRC的许多研究人员将参与或希望参与基因操纵的AD小鼠模型的行为和/或组织病理学研究。小鼠行为和神经病理学（MBN）核心是ADRC设计和实施此类研究的核心，利用MBN核心的设备和专业知识。因此，MBN核心的主要功能将是使其他Pi及其实验室人员熟悉行为/组织病理学数据的收集和分析，并提供解释所获得结果的专业知识。具体来说，MBN核心将1)设计和实施基因操纵的行为/组织病理学研究

It is expected that a number of researchers in the ADRC will be involved with, or wish to become involved with, behavioral and/or histopathologic studies in genetically-manipulated mouse models for AD. The Mouse Behavior and Neuropathology (MBN) core is the central core through which such studies will be designed and performed at the ADRC, utilizing equipment and expertise of the MBN Core. Thus, the main function of the MBN Core will be to acquaint other Pi's and their laboratory personnel with the collection and analysis of behavioral/histopathologic data, as well as provide expertise in the interpretation of results obtained. Specifically, the MBN Core will 1) design and carry out behavioral/histopathologic studies in geneticallymanipulated mouse models of AD that involve MBN Core personnel 2) assist other ADRC researchers in designing and carrying out mouse behavioral/histopathologic studies that relate to the research questions they are addressing 3) provide training and consultation in behavioral and histopathologic methodologies to ADRC researchers, and those utilizing ADRC resources, so that they may incorporate such methodologies into their research and utilize these methodologies independently within the MBN Core facilities, and 4) provide behavioral and histopathologic data to the Data Management, Biostatistics, and Epidemiology (DMBE) Core from projects and studies performed within the MBN Core. The DMBE will then store/analyze these data, determine any correlations/inter-relationships between behavioral and histopathologic data in any given study, and provide any interfacing statistical analyses between MBN data (e.g., Project #3) and that attained from related clinical projects (e.g., Project #2). The work of this Core is absolutely essential for investigating Alzheimer's disease mechanisms, genetics, risk factors and treatments in the context of this ADRC proposal.