MOUSE BEHAVIOR AND NEUROPATHOLOGY CORE

预计 ADRC 的许多研究人员将参与或希望参与 AD 基因操作小鼠模型的行为和/或组织病理学研究。小鼠行为和神经病理学 (MBN) 核心是 ADRC 设计和开展此类研究的核心，利用 MBN 核心的设备和专业知识。因此，MBN 核心的主要功能是让其他 Pi 及其实验室人员熟悉行为/组织病理学数据的收集和分析，并提供解释所获得结果的专业知识。具体来说，MBN 核心将 1) 设计并开展基因操作的行为/组织病理学研究 涉及 MBN 核心人员的 AD 小鼠模型 2) 协助其他 ADRC 研究人员 设计和开展与其正在解决的研究问题相关的小鼠行为/组织病理学研究 3) 向 ADRC 研究人员和利用 ADRC 资源的人员提供行为和组织病理学方法方面的培训和咨询，以便他们可以将此类方法纳入其研究并在 MBN 核心设施内独立利用这些方法，以及 4) 向数据管理、生物统计学和流行病学 (DMBE) 核心提供来自 MBN 核心内进行的项目和研究的行为和组织病理学数据。然后，DMBE 将存储/分析这些数据，确定任何给定研究中行为和组织病理学数据之间的任何相关性/相互关系，并提供 MBN 数据（例如项目 #3）和 从相关临床项目（例如项目#2）获得的结果。该核心的工作对于在 ADRC 提案的背景下研究阿尔茨海默氏病机制、遗传学、危险因素和治疗绝对至关重要。

It is expected that a number of researchers in the ADRC will be involved with, or wish to become involved with, behavioral and/or histopathologic studies in genetically-manipulated mouse models for AD. The Mouse Behavior and Neuropathology (MBN) core is the central core through which such studies will be designed and performed at the ADRC, utilizing equipment and expertise of the MBN Core. Thus, the main function of the MBN Core will be to acquaint other Pi's and their laboratory personnel with the collection and analysis of behavioral/histopathologic data, as well as provide expertise in the interpretation of results obtained. Specifically, the MBN Core will 1) design and carry out behavioral/histopathologic studies in geneticallymanipulated mouse models of AD that involve MBN Core personnel 2) assist other ADRC researchers in designing and carrying out mouse behavioral/histopathologic studies that relate to the research questions they are addressing 3) provide training and consultation in behavioral and histopathologic methodologies to ADRC researchers, and those utilizing ADRC resources, so that they may incorporate such methodologies into their research and utilize these methodologies independently within the MBN Core facilities, and 4) provide behavioral and histopathologic data to the Data Management, Biostatistics, and Epidemiology (DMBE) Core from projects and studies performed within the MBN Core. The DMBE will then store/analyze these data, determine any correlations/inter-relationships between behavioral and histopathologic data in any given study, and provide any interfacing statistical analyses between MBN data (e.g., Project #3) and that attained from related clinical projects (e.g., Project #2). The work of this Core is absolutely essential for investigating Alzheimer's disease mechanisms, genetics, risk factors and treatments in the context of this ADRC proposal.