Photograph Reading Center for the Comparison of AMD Treatment Trials

描述（由申请人提供）：AMD治疗试验比较（CATT）是两项连续、多中心、随机临床试验的提案，旨在比较新生血管AMD的治疗-第一项是单药治疗试验，第二项是联合治疗试验。本眼底照片阅读中心（FPRC）申请中提出的活动的主要目标是为CATT提供支持。该项目的长期目标将通过两项拟议试验的实施来实现：1）通过彩色眼底照片和荧光素血管造影来识别最有可能从预防性策略或治疗中获益的眼睛，这些预防性策略或治疗旨在预防AMD患者的视力丧失或改善其视敏度; 2）通过荧光素血管造影确定研究招募的资格以及治疗何时有效;和3）为脉络膜新生血管的血管造影特征与眼相干性捕获的血管造影特征之间的直接比较提供基础断层扫描这些目标将通过以下具体目标实现：具体目标1：建立基础设施，以处理CATT临床中心提交给FPRC的彩色眼底照相和荧光素血管造影数字图像。具体目标二：与协调中心合作，为CATT临床研究者、临床协调员和摄影师制定并实施摄影认证和培训计划，以准备CATT。具体目标3：为CATT提供提交的彩色照片和血管造影图像材料的可靠、及时、可再现和系统分级。 为了实现这些目标，中非共和国警察研究中心开发了提交光盘图像、接收光盘和将图像下载到中非共和国警察研究中心图像数据库以及对数字图像进行分级的模块。我们将建立安全的方法，将数据从FPRC传输到协调中心。FPRC还将为分级员、摄影师、诊所协调员和眼科医生认证和培训提供材料和方法，并支持研究目标，作为招募、研究组会议、演示和出版物的图像资源。

DESCRIPTION (provided by applicant): The Comparison of AMD Treatment Trials (CATT) is a proposal of two consecutive, multi-centered, randomized clinical trials to compare treatments for neovascular AMD-the first a monotherapy trial, and the second a combination therapy trial. The primary objective of the activities proposed in this Fundus Photograph Reading Center (FPRC) application is to provide support to the CATT. The long term goals of this project, that will be accomplished through the conduct of the two proposed trials are: 1) to identify by color fundus photographs and fluorescein angiograms those eyes that are most likely to benefit from preventative strategies or treatments designed to prevent vision loss, or improve visual acuity in eyes with AMD; 2) to determine by fluorescein angiography eligibility for study enrollment and when treatment is effective; and 3) to provide a basis for direct comparison between angiographic characteristics of choroidal neovascularization and those captured by ocular coherence tomograms. These goals will be accomplished via the following specific aims: Specific Aim 1: Establish the infrastructure to process color fundus photographic and fluorescein angiographic digital images that will be submitted by CATT clinical centers to the FPRC. Specific Aim 2: Collaborate with the Coordinating Center to establish and implement photographic certification and training programs for CATT clinical study investigators, clinic coordinators, and photographers in preparation of CATT. Specific Aim 3: Provide reliable, timely, reproducible, and systematic grading of submitted color photograph photographs and angiographic image materials for CATT. To achieve these aims, the FPRC has developed modules for submission of images on CD's, receipt of CD's and downloading of images to the FPRC image data base, and for grading digital images. We will establish secure methods to transmit data from the FPRC to the Coordinating Center. The FPRC also will implement materials and methods for grader, photographer, clinic coordinator, and ophthalmologist certification and training, and support study goals as an image resource for recruitment, Study Group meetings, presentations and publications.