Choroidal circulation in age related macular degeneration

年龄相关性黄斑变性中的脉络膜循环

• 批准号: 7139962
• 负责人: JUAN E GRUNWALD
• 金额: $ 34.68万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7139962
• 关键词: aging; cardiovascular disorder; clinical research; disease /disorder etiology; eye surgery; fovea centralis retinae; human subject; human therapy evaluation; longitudinal human study; macular degeneration; photocoagulation therapy; retina circulation; ultrasound blood flow measurement

DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is the leading cause of blindness in people over the age of 65 in the United States. About 10% of the U.S. population will develop AMD and 1% may suffer from the more advanced, exudative form of the disease that leads to severe visual impairment. The basic mechanism involved in the development of this disease is not clearly understood. Several reports and some preliminary data from our laboratory have suggested abnormalities of the choroidal circulation in AMD. These reports are of great interest because this circulation supplies all metabolites and removes all waste products from the outer-retina. An abnormal choroidal circulation could have a role in the process that leads to the accumulation of drusen, one. of the hallmarks of this disease. In addition, a decreased choroidal vascular supply could also lead to ischemia and hypoxia of the outer retina and this could be associated with the development of choroidal neovascularization, a blinding complication of AMD. This is a continuation proposal aimed at expanding the scope of the studies proposed originally. The main aim of these studies is to use the state-of-the-art, non-invasive technique of laser Doppler flowmetry to investigate whether choroidal blood flow and its regulation are abnormal in AMD. In addition we will investigate whether a more abnormal choroidal circulation is associated with a higher risk of developing choroidal neovascularization and the more advanced and blinding stages of AMD. A better understanding of the mechanisms associated with the development of AMD could, in the long run, help us devise new treatment strategies for this devastating disease. In addition, the knowledge gained through this investigation could also help in the identification of patients at risk of developing choroidal neovascularization, thus enabling earlier treatment.

描述（由申请人提供）：年龄相关性黄斑变性 (AMD) 是美国 65 岁以上人群失明的主要原因。大约 10% 的美国人会患上 AMD，1% 的人可能患有更严重的渗出性疾病，从而导致严重的视力障碍。这种疾病发生的基本机制尚不清楚。我们实验室的一些报告和一些初步数据表明 AMD 的脉络膜循环存在异常。这些报告引起了人们极大的兴趣，因为这种循环提供了所有代谢物并清除了外视网膜的所有废物。异常的脉络膜循环可能在导致玻璃疣积聚的过程中发挥作用，其中之一。这种疾病的特征。此外，脉络膜血管供应减少还可能导致外视网膜缺血和缺氧，这可能与脉络膜新生血管形成（AMD 的致盲并发症）的发生有关。这是一项延续提案，旨在扩大最初提出的研究范围。这些研究的主要目的是利用最先进的、非侵入性的激光多普勒血流测定技术来研究AMD患者的脉络膜血流及其调节是否异常。此外，我们将研究更异常的脉络膜循环是否与发生脉络膜新生血管的更高风险以及AMD的更晚期和致盲阶段相关。从长远来看，更好地了解与 AMD 发展相关的机制可以帮助我们为这种毁灭性疾病制定新的治疗策略。此外，通过这项研究获得的知识还可以帮助识别有脉络膜新生血管形成风险的患者，从而实现早期治疗。