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IOWA AND MISSOURI RADON LUNG CANCER STUDIES

爱荷华州和密苏里州氡气肺癌研究

基本信息

批准号：
7501832
负责人：
Robert William Field
金额：
$ 1万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-01-17 至 2007-12-31
项目状态：
已结题

项目摘要

Risk estimates, extrapolated from studies of underground miners, predict that residential radon progeny exposure accounts for approximately 19,000 lung cancer deaths each year in the United States. Previous case-control epidemiologic studies, which examined the relationship between residential radon exposure and lung cancer, lacked the ability to verify these risk estimates. Inaccurate dose assessment of radon exposure, a high percentage of proxy respondents, inadequate pathologic review, and low residential radon concentrations led to exposure misclassification and limited the interpretation of these studies. The Iowa Radon Lung Cancer Phase I study was designed to overcome many of these limitations. The Phase I study utilized advanced radon dose assessments, independent histologic review, and a study population that was characterized by geographic stability, high percentage of live cases, and potential for high radon exposure. The Phase I study demonstrated that exposure to residential radon gas increases the risk of developing lung cancer. To refine these estimates, we now propose Phase II studies that examine the association between residential radon product (progeny) exposure and the development of lung cancer. Because radon progeny deliver the actual radiation dose to the lung tissues, rather than radon gas itself, in order to reduce further the exposure misclassification, radon dose estimates need to take into account exposure to residential radon progeny. This requires measuring actual airborne radon progeny concentrations and integrating the exposure to radon progeny over time. The Phase II study will derive more accurate retrospective radon dose estimates by using a novel retrospective radon progeny integrating glass-based detector. Specific Aim I examines the hypothesis that exposure to residential radon progeny is associated with increased risk of developing lung cancer, after controlling for confounders. We will perform field calibration and laboratory validation of the retrospective radon "glass" detectors, and analyze the risk estimates by incorporating exposures to radon progeny, rather than exposures to radon gas. Specific Aim II will determine whether the shape of the dose response curve that best describes the relationship between residential radon progeny exposure and lung cancer risk is linear or nonlinear. Specific Aim III will examine whether exposure to radon progeny contributes to the development of adenocarcinoma, as well as other lung cancer histologic types. For Aims II and III we will use pooled analyses of exposure estimates that are derived from retrospective radon progeny "glass" detectors for subjects from the Iowa and Missouri Radon Lung Cancer Studies. The pooling of data between two large-scale epidemiologic studies from a similar geographic area, Iowa and Missouri, will allow us to increase sample size and statistical power.

根据对地下矿工的研究推断出的风险估计，美国每年约有19 000人死于氡子体暴露。以前的病例对照流行病学研究，检查住宅氡暴露和肺癌之间的关系，缺乏验证这些风险估计的能力。不准确的剂量评估氡暴露，高比例的代理受访者，不充分的病理审查，低住宅氡浓度导致暴露错误分类，并限制了这些研究的解释。爱荷华州氡肺癌I期研究旨在克服这些局限性。I期研究采用了先进的氡剂量评估，独立的组织学审查，研究人群的特点是地理稳定性，高比例的活病例，高氡暴露的潜力。第一阶段研究表明，暴露于住宅氡气会增加患肺癌的风险。为了完善这些估计，我们现在提出了第二阶段的研究，检查住宅氡产品（后代）暴露和肺癌的发展之间的关联。由于氡子体将实际辐射剂量传递到肺组织，而不是氡气本身，为了进一步减少暴露错误分类，氡剂量估计需要考虑到住宅氡子体的暴露。这需要测量实际的空气中氡子体浓度，并将氡子体暴露量随时间的变化进行积分。第二阶段的研究将得出更准确的回顾性氡剂量估计使用一种新的回顾性氡子体集成玻璃探测器。具体目标我检查的假设，暴露于住宅氡子体与肺癌的风险增加，控制混杂因素后。我们将进行现场校准和实验室验证的回顾性氡“玻璃”探测器，并分析的风险估计纳入暴露于氡子体，而不是暴露于氡气。具体目标II将确定最能描述住宅氡子体暴露与肺癌风险之间关系的剂量反应曲线的形状是线性还是非线性。具体目标III将检查氡子体暴露是否有助于腺癌以及其他肺癌组织学类型的发展。对于目标II和III，我们将使用来自爱荷华州和密苏里州氡肺癌研究受试者的回顾性氡子体“玻璃”探测器的暴露估计值的汇总分析。两个大规模流行病学研究的数据汇集在一个相似的地理区域，爱荷华州和密苏里州，将使我们能够增加样本量和统计能力。