8th International Symposium for VIP, PACAP & Related Peptides

第八届VIP国际研讨会，PACAP

• 批准号: 7276319
• 负责人: VICTOR MAY
• 金额: $ 0.7万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7276319
• 关键词: Amino Acids; Apoptotic; California; Cardiovascular system; Cells; Clinical; Denmark; Development; Distant; Endocrine; Family; Family member; Fostering; France; Future; G-Protein-Coupled Receptors; GLP-2; Gastric Inhibitory Polypeptide; Genes; Germ Cells; Germany; Glucagon; Goals; Hormones; Immune; Information Technology; Injury; International; Japan; Laboratories; Laboratory Study; Learning; Louisiana; Mediating; Natural regeneration; Neurosecretory Systems; Peptides; Peripheral Nervous System; Physiological; Pituitary Gland; Production; Receptor Signaling; Reproductive system; Research; Research Personnel; Resort; Scheme; Secretin; Sensory; Signal Transduction; Site; Somatotropin-Releasing Hormone; Structure; Technology Transfer; Therapeutic; Thyroid Function Tests; Vasoactive Intestinal Peptide; Vermont; blood glucose regulation; gastrointestinal; glucagon-like peptide 1; member; memory process; neurotrophic factor; pituitary adenylate cyclase activating polypeptide; respiratory; response; symposium; urinary

DESCRIPTION (provided by applicant): The 8th International Symposium on VIP, PACAP, and Related Peptides is planned for September 3 - 8, 2007 at The Equinox Spa and Resort in Manchester, Vermont. Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are members of a superfamily composed of six genes encoding nine bioactive peptides. As PACAP and VIP developed within one branch of the evolutionary scheme, the two peptides are highly related not only in structure but also in function from shared G-protein-coupled receptors. PACAP/VIP amino acid homology with the other related peptides, including growth hormone releasing hormone (GHRH), secretin, glucagon, glucagon-like peptide-1 (GLP-1), GLP-2, and glucose-dependent insulinotropic peptide (GIP) is more distant but in aggregate, members of PACAP/VIP family have critical functions across broad physiological spectrums. Various peptide members behave as transmitters in central and peripheral nervous systems to participate not only in neuroendocrine, learning and memory processes, but also in sensory and autonomic control of cardiovascular, gastrointestinal, urinary, respiratory, and reproductive systems. Some of these peptides are unique in their dual functions as potent neurotrophic factors during development and injury paradigms to facilitate cellular survival and regeneration against diverse apoptotic signals. Other family members can behave as classical endocrine regulators of hormone production and secretion, mediating of pituitary/thyroid function, glucose homeostasis, immune cell responses, and germ cell development. Accordingly, the functional and therapeutic significance of these peptides can be exceedingly broad. This is a biennial conference of more than 175 researchers from leading international laboratories studying the expression, receptor signaling, and functional attributes of VIP, PACAP, and related peptides. In keeping with the international spirit, the meeting sites have alternated on different continents; the first symposium was held in 1993 in Strasbourg (France) and the second in 1995 in New Orleans (Louisiana, USA). Subsequent meetings were held in Freiburg (Germany) in 1997, Elsinor (Denmark) in 1999, Santa Barbara (California, USA) in 2001, Hakone (Japan) in 2003 and most recently in Rouen (France) in 2005. The major aims of the conference have been threefold: 1) to provide a central forum to disseminate new and largely unpublished information among investigators as a means of promoting research; 2) to identify important thematic and technological advancements in the field with goals for clinical therapeutics; and 3) to attract new investigators to the field to foster future research. From previous meetings, the interactions among international laboratories have been stimulating, strong, and durable. The 8th International Symposium aims to continue that information and technology transfer to accelerate new developments.

第八届VIP， PACAP和相关肽国际研讨会计划于2007年9月3日至8日在佛蒙特州曼彻斯特的Equinox水疗度假村举行。垂体腺苷酸环化酶激活多肽（PACAP）和血管活性肠肽（VIP）是一个由6个基因组成的超家族成员，编码9种生物活性肽。由于PACAP和VIP在同一个进化分支中发育，这两种肽不仅在结构上而且在功能上都有高度的相关性，它们都是共享的g蛋白偶联受体。PACAP/VIP家族成员与其他相关肽，包括生长激素释放激素（GHRH）、分泌素、胰高血糖素、胰高血糖素样肽-1 （GLP-1）、GLP-2和葡萄糖依赖性胰岛素肽（GIP）的氨基酸同源性更远，但总的来说，PACAP/VIP家族成员在广泛的生理光谱中具有重要功能。多种多肽成员在中枢和外周神经系统中作为递质，不仅参与神经内分泌、学习和记忆过程，还参与心血管、胃肠、泌尿、呼吸和生殖系统的感觉和自主控制。其中一些肽具有独特的双重功能，在发育和损伤过程中作为有效的神经营养因子，促进细胞存活和再生，对抗各种凋亡信号。其他家族成员可以作为激素产生和分泌的经典内分泌调节因子，介导垂体/甲状腺功能，葡萄糖稳态，免疫细胞反应和生殖细胞发育。因此，这些肽的功能和治疗意义非常广泛。这是一次两年一次的会议，来自国际领先实验室的175多名研究人员研究VIP、PACAP和相关肽的表达、受体信号和功能属性。为符合国际精神，会议地点在各大洲轮流举行；第一次专题讨论会于1993年在斯特拉斯堡（法国）举行，第二次讨论会于1995年在新奥尔良（美国路易斯安那州）举行。随后的会议分别于1997年在德国弗莱堡、1999年在丹麦埃尔西诺、2001年在美国加州圣巴巴拉、2003年在日本箱根和2005年在法国鲁昂举行。会议的主要目的有三个：1)提供一个中心论坛，在研究人员之间传播新的和大部分未发表的信息，作为促进研究的一种手段；2)确定该领域的重要主题和技术进展，以实现临床治疗目标；3)吸引新的研究者进入该领域，以促进未来的研究。从以前的会议来看，国际实验室之间的互动是刺激的，强大的，持久的。第八届国际研讨会旨在继续信息和技术转让，以加速新的发展。