Chemical Toxicology in the Study of Disease Etiology

疾病病因学研究中的化学毒理学

• 批准号: 7559763
• 负责人: Amanda C Bryant-Friedrich
• 金额: $ 1.55万
• 依托单位: UNIVERSITY OF TOLEDO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-16 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7559763
• 关键词: Aging; American; Analytical Chemistry; Animal Model; Applications Grants; Area; Award; Biological; Biological Markers; Biological Process; Boston; Cancer Etiology; Chemical Models; Chemicals; Chemistry; Communication; Communities; Degenerative Disorder; Development; Discipline; Disease; Disease susceptibility; Drug Industry; Ensure; Environmental Exposure; Environmental Health; Etiology; Exposure to; Functional disorder; Funding; Future; Goals; Growth; Human; In Vitro; Investigation; Malignant Neoplasms; Mass Spectrum Analysis; Massachusetts; Medicine; Methods; Numbers; Organic Chemistry; Participant; Pharmaceutical Preparations; Play; Postdoctoral Fellow; Process; Purpose; Research; Risk; Role; Science; Scientist; Sensitivity and Specificity; Societies; Students; Technology; Title; Toxic Environmental Substances; Toxic effect; Toxicology; Travel; United States National Institutes of Health; Validation; Work; Zebrafish; age related; analytical method; base; chemical carcinogenesis; disorder risk; drug discovery; human disease; improved; in vivo; interest; next generation; programs; success; symposium; technique development; tool

DESCRIPTION (provided by applicant) This conference grant application requests funding for the partial support of a symposium with the title "Chemical Toxicology in the Study of Disease Etiology". This symposium is part of the program to be presented by the American Chemical Society Division of Chemical Toxicology at the 234th National Meeting and Exposition of the Society in Boston Massachusetts on August 19 and 22, 2007. The objective of this symposium is to bring to the chemical community, the advancements and challenges surrounding the development and application of biomarkers and animal models in the determination of disease etiology and drug discovery. Tools for the quantification and characterization of altered biological molecules that result from the action of environmental toxins and drugs have improved dramatically in both their sensitivity and specificity. The use of such tools is critical in the in vitro and in vivo facets of the development of biomarkers of exposure, pathophysiology and disease risk in humans. The contribution of the chemical community to the development of techniques in this arena has increased greatly in recent years, with future growth only limited by lack of cross-talk between the large numbers of disciplines involved in this area of the biomedical sciences, hence the need for this symposium. The three sessions of the proposed symposium are devoted to critical areas of interest in this arena and include: a.) Zebrafish as a model for chemical toxicology; b) DNA-based biomarkers, and c.) Applications of mass spectrometry in chemical toxicology. Highly respected scientists from a variety of disciplines have agreed to present their most recent findings in these areas. The symposium will have particular relevance to the goals of the National Institutes of Health in the areas of environmental health, cancer etiology, aging and general medicine. The broader scientific community will also find the information presented relevant in the fields of biological, medicinal and analytical chemistry as well as chemical toxicologist. Travel awards will be made to graduate students and postdoctoral fellows to ensure that the next generation of scientists is aware of the important advances in the fields of drug discovery, mass spectrometry, synthetic organic chemistry and chemical carcinogenesis to mention a few and how they work in concert to develop new ways to determine disease etiology and risk.

描述（由申请人提供） 本次会议的资助申请要求资助一个题为“疾病病因学研究中的化学毒理学”的研讨会的部分支持。本次研讨会是美国化学学会化学毒理学分部将于2007年8月19日和22日在马萨诸塞州波士顿举行的第234届全国会议和学会博览会上提出的计划的一部分。本次研讨会的目的是为化学界带来围绕生物标志物和动物模型在确定疾病病因和药物发现方面的发展和应用的进步和挑战。用于量化和表征因环境毒素和药物作用而改变的生物分子的工具在灵敏度和特异性方面都有了显著提高。这些工具的使用是至关重要的，在体外和体内方面的接触，病理生理学和人类疾病风险的生物标志物的发展。近年来，化学界对这一竞技场技术发展的贡献大大增加，未来的增长只受到生物医学科学这一领域所涉及的大量学科之间缺乏相互交流的限制，因此需要举办这次专题讨论会。拟议的专题讨论会的三次会议专门讨论这一竞技场中感兴趣的关键领域，包括：斑马鱼作为化学毒理学模型; B）基于DNA的生物标志物，和c.）质谱法在化学毒理学中的应用。来自不同学科的备受尊敬的科学家同意展示他们在这些领域的最新发现。该专题讨论会将与美国国立卫生研究院在环境卫生、癌症病因学、老龄化和普通医学领域的目标特别相关。更广泛的科学界也会发现所提供的信息与生物、医药和分析化学以及化学毒理学领域有关。将向研究生和博士后研究员提供旅行奖励，以确保下一代科学家了解药物发现，质谱，合成有机化学和化学致癌等领域的重要进展，以及他们如何协同工作以开发确定疾病病因和风险的新方法。