Gastrointestinal Response to Injury: Canada 2007

描述(申请者提供)：“胃肠对伤害的反应：加拿大2007”将是一系列会议中的第六次。第一次会议于1992年在科罗拉多州的铜山举行，最初的标题是“胃十二指肠粘膜防御的细胞和分子基础”，此后每三年举行一次会议。第四次和第五次会议(2001年和2004年)在加拿大魁北克省蒙特贝洛堡举行。这些后来的会议为该计划引入了更广泛的范围，其中包括调查结肠和整个小肠以及上胃肠道的胃肠粘膜防御。这种形式，以及地点，增强了该系列的成功。拟议的会议名为“胃肠对损伤的反应：加拿大2007”，讨论与影响整个腔胃肠道的疾病相关的重要和前沿话题。该计划包括三个部分，每个部分由两个单独的会议组成。第一部分研究调节胃肠道损伤反应的因素，包括1)粘膜屏障，2)免疫系统。第二部分胃肠损伤的诱因和机制：3)非甾体抗炎药、氧化应激和其他黏膜损伤因素；4)微生物与宿主的相互作用。第三部分讨论肠道损伤的表现和在5)愈合、修复和癌变以及6)慢性炎症及其临床后果(包括炎症性肠病)的治疗过程中对疾病结果的潜在调节作用。这次会议的一个主要目标是为年轻科学家提供一个独特的机会，使他们能够在开放的环境中接触到损伤胃肠反应领域的最新研究，在这种环境中，他们可以与来自世界各地的知名研究人员进行正式和非正式的互动。会议还将促进从事胃肠生物学不同方面工作的科学家之间的互动，以及基础和临床研究人员之间的互动。自1998年以来，该会议第一次有了一个主要赞助商(AGA研究所)，此外还有工业界提供的教育赠款，用于支付会议费用，包括由8名妇女、5名种族/族裔少数群体(包括2名传统上任职人数偏低的少数群体)和6名初级调查员组成的26名特邀演讲者和/或会议主席的旅费、餐饮和住宿。这项申请要求提供所需的资金，以支持年轻见习调查员的出席费用，否则他们可能没有机会参加这样的会议。这项申请的目的是获得旅行奖励的资金，以促进年轻科学家参加“胃肠对伤害的反应：加拿大2007”。

DESCRIPTION (provided by applicant): "Gastrointestinal Response to Injury: Canada 2007" will be the sixth in a series of meetings. The first meeting was held at Copper Mountain, Colorado in 1992, originally entitled "The Cellular and Molecular Basis of Gastroduodenal Mucosal Defense", and subsequent meetings have taken place every three years since. The fourth and fifth meeting (2001 and 2004) were held at Chateau Montebello, Quebec, Canada. These later meetings introduced a broader scope to the program, which included investigation of gastrointestinal mucosal defense in the colon and entire small intestine as well as the upper gastrointestinal tract. This format, as well as the location, enhanced the success of the series. The proposed meeting, "Gastrointestinal Response to Injury: Canada 2007", addresses important and cutting edge topics relevant to diseases affecting the entire luminal GI tract. The program includes three parts each consisting of two separate sessions. Part I examines factors regulating gastrointestinal responses to injury including 1) the mucosal barrier, and 2) the immune system. The second part, agents and mechanisms of gastrointestinal injury addresses 3) NSAIDs, oxidative stress, and other agents of mucosal injury, and 4) microbial-host interactions. Part III addresses manifestations of gut injury and potential to modulate disease outcomes in sessions on 5) healing, repair, and carcinogenesis, and 6) chronic inflammation and its clinical consequences including inflammatory bowel disease. A major goal of this meeting is to provide young scientists with a unique exposure to current research in the field of gastrointestinal responses to injury in an open environment in which they can interact formally and informally with established investigators from around the world. The meeting will also foster interactions among scientists working in different aspects of gastroenteric biology as well as those between basic and clinical investigators. For the first time since 1998, the meeting has a major sponsor (the AGA Institute), in addition to support by educational grants from industry that will support costs of the meeting including travel, meals and accommodation for 26 invited speakers and/or session chairs comprised of 8 women, 5 racial/ethnic minorities (including 2 traditionally underrepresented minorities), and 6 junior investigators. This application requests funds needed to support the costs of attendance for young trainee investigators who otherwise might not have the opportunity to attend such a meeting. The aim of this application is to obtain the funds for travel awards to facilitate the participation of young scientists in "Gastrointestinal Response to Injury: Canada 2007."