Oral Screening in India using Optical Imaging Technology

印度使用光学成像技术进行口腔筛查

基本信息

  • 批准号:
    7290903
  • 负责人:
  • 金额:
    $ 2.96万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-07-01 至 2010-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Oral cancer is the sixth most common cancer worldwide and over two thirds of cases occur in developing countries. In India, it is the most common cancer in men and the third most common in women. Only half of oral cancer patients live 5 years, even less of those with advanced stage disease survive. Advances in early detection and diagnosis would greatly improve survival and decrease suffering from oral cancer. Optical based diagnostic aids are promising new technologies to improve detection of epithelial malignancies. During carcinogenesis, the optical properties of tissue are altered and these changes can be used to non-invasively distinguish normal from neoplastic mucosa. The objective of this international collaborative project, which builds upon previous NIH funded work, is to determine whether new optical imaging technology, fluorescence and reflectance imaging and spectroscopy, can facilitate early detection and diagnosis of oral neoplasia in a high risk population in India. Our first Aim is to determine whether multispectral imaging and spectroscopy can improve screening and diagnosis of potentially malignant oral lesions in a high risk population in India. We will obtain wide-field autofluorescence and reflectance images of oral premalignant lesions (OPLs) in 90 patients who are recruited for oral cancer screening trials at the Tata Memorial Hospital in Mumbai India. These images will be compared to findings using standard white light (WL) illumination. At the same time, an in depth, focal interrogation from several sites using fluorescence and reflectance spectra will be performed. Clinical diagnoses using standard white light, clinical diagnoses using multispectral imaging, spectroscopy data, and cytology and histopathology diagnoses will be compared to determine the positive and negative predictive value of using the device. In Aim 2, we will determine whether this technology can improve screening and diagnosis in an Indian population with high risk for oral cancer but no clinically visible lesions using similar methodology. In Aim 3, we evaluate the correlation of presence of genetic damage (such as aneuploidy and loss of heterozygosity) and morphologic changes (hyperkeratosis, inflammation, dysplasia) to altered optical signatures. Successful completion of this project will determine the diagnostic potential and applicability of this technology for oral cancer detection and diagnosis in communities with limited resources. 7. Project Narrative Oral cancer is the sixth most common cancer worldwide and over two thirds of cases occur in developing countries. In India, it is the most common cancer in men and the third most common in women. Only half of oral cancer patients live 5 years, even less of those with advanced stage disease survive. Advances in early detection and diagnosis would greatly improve survival and decrease suffering from oral cancer. Optical based diagnostic aids are promising new technologies to improve detection of epithelial malignancies. The objective of this international collaborative project, which builds upon previous NIH funded work, is to determine whether new optical imaging technology, fluorescence and reflectance imaging and spectroscopy, can facilitate early detection and diagnosis of oral neoplasia in a high risk population in India. We will determine whether multispectral imaging and spectroscopy can improve screening and diagnosis of potentially malignant oral lesions in a high risk population in India. We will compare optical data in 190 subjects who are recruited for oral cancer screening trials at the Tata Memorial Hospital in Mumbai India, to standard clinical diagnosis, histopathologic results, and molecular biomarker findings. Successful completion of this project will determine the diagnostic potential and applicability of this multispectral imaging and spectrsocpy technology for oral cancer detection and diagnosis in communities with limited resources.
描述(申请人提供):口腔癌是全球第六大常见癌症,超过三分之二的病例发生在发展中国家。在印度,它是男性最常见的癌症,女性第三常见。只有一半的口腔癌患者能活5年,更少的晚期患者能存活。早期检测和诊断的进步将大大提高生存率,减少口腔癌的痛苦。基于光学的诊断辅助工具是改善上皮恶性肿瘤检测的有前途的新技术。在癌变过程中,组织的光学特性发生改变,这些变化可用于非侵入性地区分正常粘膜和肿瘤粘膜。这个国际合作项目的目标,建立在以前的NIH资助的工作,是确定是否新的光学成像技术,荧光和反射成像和光谱,可以促进早期检测和诊断口腔肿瘤在印度的高危人群。我们的第一个目标是确定多光谱成像和光谱学是否可以改善印度高危人群中潜在恶性口腔病变的筛查和诊断。我们将在印度孟买的塔塔纪念医院获得90名口腔癌筛查试验患者的口腔癌前病变(OPL)的宽视野自体荧光和反射图像。将这些图像与使用标准白色光(WL)照明的结果进行比较。同时,将使用荧光和反射光谱对几个部位进行深入的焦点询问。将比较使用标准白色光的临床诊断、使用多光谱成像的临床诊断、光谱数据以及细胞学和组织病理学诊断,以确定使用该器械的阳性和阴性预测值。在目标2中,我们将确定这项技术是否可以使用类似的方法改善印度口腔癌高风险人群的筛查和诊断,但没有临床可见的病变。在目标3中,我们评估了遗传损伤(如非整倍体和杂合性丢失)和形态学变化(角化过度、炎症、发育不良)与光学特征改变的相关性。该项目的成功完成将决定该技术在资源有限的社区中用于口腔癌检测和诊断的诊断潜力和适用性。7.口腔癌是全球第六大常见癌症,超过三分之二的病例发生在发展中国家。在印度,它是男性最常见的癌症,女性第三常见。只有一半的口腔癌患者能活5年,更少的晚期患者能存活。早期检测和诊断的进步将大大提高生存率,减少口腔癌的痛苦。基于光学的诊断辅助工具是改善上皮恶性肿瘤检测的有前途的新技术。这个国际合作项目的目标,建立在以前的NIH资助的工作,是确定是否新的光学成像技术,荧光和反射成像和光谱,可以促进早期检测和诊断口腔肿瘤在印度的高危人群。我们将确定多光谱成像和光谱学是否可以改善印度高危人群中潜在恶性口腔病变的筛查和诊断。我们将比较在印度孟买塔塔纪念医院招募的190名口腔癌筛查试验受试者的光学数据与标准临床诊断、组织病理学结果和分子生物标志物结果。该项目的成功完成将确定这种多光谱成像和光谱技术在资源有限的社区中用于口腔癌检测和诊断的诊断潜力和适用性。

项目成果

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Ann M Gillenwater其他文献

Ann M Gillenwater的其他文献

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{{ truncateString('Ann M Gillenwater', 18)}}的其他基金

Deep learning microscope for slide-free and digital histology
用于无载玻片和数字组织学的深度学习显微镜
  • 批准号:
    10503039
  • 财政年份:
    2022
  • 资助金额:
    $ 2.96万
  • 项目类别:
Deep learning microscope for slide-free and digital histology
用于无载玻片和数字组织学的深度学习显微镜
  • 批准号:
    10664026
  • 财政年份:
    2022
  • 资助金额:
    $ 2.96万
  • 项目类别:
Mobile Imaging for Oral Cancer Screening Programs in Rural US Settings
美国农村地区口腔癌筛查项目的移动成像
  • 批准号:
    10396044
  • 财政年份:
    2021
  • 资助金额:
    $ 2.96万
  • 项目类别:
Mobile Imaging for Oral Cancer Screening Programs in Rural US Settings
美国农村地区口腔癌筛查项目的移动成像
  • 批准号:
    10193591
  • 财政年份:
    2021
  • 资助金额:
    $ 2.96万
  • 项目类别:
Precision Optical Guidance for Oral Biopsy Based on Next-Generation Hallmarks of Cancer
基于下一代癌症标志的口腔活检精密光学引导
  • 批准号:
    10565685
  • 财政年份:
    2020
  • 资助金额:
    $ 2.96万
  • 项目类别:
Precision Optical Guidance for Oral Biopsy Based on Next-Generation Hallmarks of Cancer
基于下一代癌症标志的口腔活检精密光学引导
  • 批准号:
    10326402
  • 财政年份:
    2020
  • 资助金额:
    $ 2.96万
  • 项目类别:
(PQC2) Optical Hallmarks of Aggressive Clones Within Oral Field Cancerization
(PQC2) 口腔癌化中侵袭性克隆的光学标志
  • 批准号:
    9319642
  • 财政年份:
    2014
  • 资助金额:
    $ 2.96万
  • 项目类别:
(PQC2) Optical Hallmarks of Aggressive Clones Within Oral Field Cancerization
(PQC2) 口腔癌化中侵袭性克隆的光学标志
  • 批准号:
    8912436
  • 财政年份:
    2014
  • 资助金额:
    $ 2.96万
  • 项目类别:
Oral Screening in India using Optical Imaging Technology
印度使用光学成像技术进行口腔筛查
  • 批准号:
    7463924
  • 财政年份:
    2007
  • 资助金额:
    $ 2.96万
  • 项目类别:
Oral Screening in India using Optical Imaging Technology
印度使用光学成像技术进行口腔筛查
  • 批准号:
    7615710
  • 财政年份:
    2007
  • 资助金额:
    $ 2.96万
  • 项目类别:

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阐明额外染色体消除对嵌合非整倍体综合征的影响:以 Pallister-Killian 综合征为模型
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