Oral Screening in India using Optical Imaging Technology

印度使用光学成像技术进行口腔筛查

• 批准号: 7290903
• 负责人: Ann M Gillenwater
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7290903
• 关键词: Algorithms; Aneuploidy; Appearance; Appendix; Area; Benign; Biological; Biological Markers; Biopsy; Breast; Cancer Center; Cancer Detection; Cancer Etiology; Cancer Patient; Cancerous; Carcinoma; Categories; Cessation of life; Clinical; Collaborations; Collagen; Communities; Country; Cytology; Data; Depth; Detection; Developed Countries; Developing Countries; Development; Devices; Diagnosis; Diagnostic; Disease; Dysplasia; Early Diagnosis; Early Intervention; Electronics; Enrollment; Environment; Epithelial; Epithelium; Evaluation; Excision; Faculty; Fiber Optics; Fluorescence; Funding; Genetic; Gold; Head and Neck Surgery; Health; Hemoglobin; Histologic; Histology; Histopathology; Hospitals; Human; Hyperkeratosis; Image; Imaging technology; India; Individual; Inflammation; Inflammatory; Institutes; International; Intervention; Invasive; Investigation; Keratin; Lateral; Lead; Lesion; Leukoplakia; Life; Light; Lighting; Localized; Loss of Heterozygosity; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of prostate; Measurement; Measures; Medical; Methodology; Microscope; Microscopic; Mitochondria; Molecular; Molecular Abnormality; Mouth Carcinoma; Mouth Neoplasms; Mucous Membrane; Neoplasms; Non-Invasive Cancer Detection; Optics; Oral; Oral Diagnosis; Oral Tobacco; Oral cavity; Oral mucous membrane structure; Organ; Outcome; Oxidation-Reduction; Patients; Pattern; Peripheral; Persons; Physicians; Pilot Projects; Population; Predictive Value; Premalignant; Property; Recruitment Activity; Relative (related person); Research Project Grants; Resolution; Resources; Risk; Sampling; Scientist; Screening for Oral Cancer; Screening for cancer; Screening procedure; Sensitivity and Specificity; Signal Transduction; Site; Smoke; Source; Southeastern Asia; Spectrum Analysis; Staging; Standards of Weights and Measures; Survival Rate; System; Techniques; Technology; Testing; Texas; Time; Tissues; Tobacco; Tobacco Use Cessation; United States; United States National Institutes of Health; Variant; Videoconferences; Videoconferencing; Visit; Woman; Work; absorption; base; cancer diagnosis; carcinogenesis; chromophore; clinical Diagnosis; computerized data processing; cost; detector; digital; experience; functional outcomes; human subject; improved; malignant mouth neoplasm; mathematical model; member; men; mortality; mouth squamous cell carcinoma; neoplastic; new technology; optical imaging; oral dysplasia; oral lesion; oral surgery specialty; oral tissue; prospective; size; tool; transmission process; tumor; volunteer

DESCRIPTION (provided by applicant): Oral cancer is the sixth most common cancer worldwide and over two thirds of cases occur in developing countries. In India, it is the most common cancer in men and the third most common in women. Only half of oral cancer patients live 5 years, even less of those with advanced stage disease survive. Advances in early detection and diagnosis would greatly improve survival and decrease suffering from oral cancer. Optical based diagnostic aids are promising new technologies to improve detection of epithelial malignancies. During carcinogenesis, the optical properties of tissue are altered and these changes can be used to non-invasively distinguish normal from neoplastic mucosa. The objective of this international collaborative project, which builds upon previous NIH funded work, is to determine whether new optical imaging technology, fluorescence and reflectance imaging and spectroscopy, can facilitate early detection and diagnosis of oral neoplasia in a high risk population in India. Our first Aim is to determine whether multispectral imaging and spectroscopy can improve screening and diagnosis of potentially malignant oral lesions in a high risk population in India. We will obtain wide-field autofluorescence and reflectance images of oral premalignant lesions (OPLs) in 90 patients who are recruited for oral cancer screening trials at the Tata Memorial Hospital in Mumbai India. These images will be compared to findings using standard white light (WL) illumination. At the same time, an in depth, focal interrogation from several sites using fluorescence and reflectance spectra will be performed. Clinical diagnoses using standard white light, clinical diagnoses using multispectral imaging, spectroscopy data, and cytology and histopathology diagnoses will be compared to determine the positive and negative predictive value of using the device. In Aim 2, we will determine whether this technology can improve screening and diagnosis in an Indian population with high risk for oral cancer but no clinically visible lesions using similar methodology. In Aim 3, we evaluate the correlation of presence of genetic damage (such as aneuploidy and loss of heterozygosity) and morphologic changes (hyperkeratosis, inflammation, dysplasia) to altered optical signatures. Successful completion of this project will determine the diagnostic potential and applicability of this technology for oral cancer detection and diagnosis in communities with limited resources. 7. Project Narrative Oral cancer is the sixth most common cancer worldwide and over two thirds of cases occur in developing countries. In India, it is the most common cancer in men and the third most common in women. Only half of oral cancer patients live 5 years, even less of those with advanced stage disease survive. Advances in early detection and diagnosis would greatly improve survival and decrease suffering from oral cancer. Optical based diagnostic aids are promising new technologies to improve detection of epithelial malignancies. The objective of this international collaborative project, which builds upon previous NIH funded work, is to determine whether new optical imaging technology, fluorescence and reflectance imaging and spectroscopy, can facilitate early detection and diagnosis of oral neoplasia in a high risk population in India. We will determine whether multispectral imaging and spectroscopy can improve screening and diagnosis of potentially malignant oral lesions in a high risk population in India. We will compare optical data in 190 subjects who are recruited for oral cancer screening trials at the Tata Memorial Hospital in Mumbai India, to standard clinical diagnosis, histopathologic results, and molecular biomarker findings. Successful completion of this project will determine the diagnostic potential and applicability of this multispectral imaging and spectrsocpy technology for oral cancer detection and diagnosis in communities with limited resources.

描述(申请人提供)：口腔癌是全球第六大常见癌症，三分之二以上的病例发生在发展中国家。在印度，它是男性最常见的癌症，在女性中排名第三。只有一半的口腔癌患者存活5年，晚期患者的存活更少。早期发现和诊断的进展将极大地提高患者的生存率，减少口腔癌的发病率。基于光学的诊断辅助是一种很有前途的新技术，可以提高对上皮性恶性肿瘤的检测。在癌变过程中，组织的光学性质会发生变化，这些变化可以用来非侵入性地区分正常粘膜和肿瘤粘膜。这一国际合作项目建立在NIH以前资助的工作基础上，目的是确定新的光学成像技术、荧光和反射成像和光谱分析是否能够促进印度高危人群口腔肿瘤的早期发现和诊断。我们的第一个目标是确定多光谱成像和光谱学是否可以改善印度高危人群中潜在恶性口腔病变的筛查和诊断。我们将获得在印度孟买塔塔纪念医院进行口腔癌症筛查试验的90名患者的口腔癌前病变(OPLS)的广域自体荧光和反射图像。这些图像将与使用标准白光(WL)照明的结果进行比较。同时，将利用荧光和反射光谱对几个地点进行深入的焦点询问。使用标准白光的临床诊断、使用多光谱成像的临床诊断、光谱数据以及细胞学和组织病理学诊断将进行比较，以确定使用该设备的阳性和阴性预测价值。在目标2中，我们将使用类似的方法确定这项技术是否可以改善对口腔癌高危但临床上没有可见病变的印度人群的筛查和诊断。在目标3中，我们评估了遗传损伤的存在(如非整倍体和杂合性丢失)和形态变化(角化过度、炎症、异型增生)与改变的光学特征的相关性。该项目的成功完成将决定这项技术在资源有限的社区中检测和诊断口腔癌的诊断潜力和适用性。7.项目叙述口腔癌是全世界第六种最常见的癌症，三分之二以上的病例发生在发展中国家。在印度，它是男性最常见的癌症，在女性中排名第三。只有一半的口腔癌患者存活5年，晚期患者的存活更少。早期发现和诊断的进展将极大地提高患者的生存率，减少口腔癌的发病率。基于光学的诊断辅助是一种很有前途的新技术，可以提高对上皮性恶性肿瘤的检测。这一国际合作项目建立在NIH以前资助的工作基础上，目的是确定新的光学成像技术、荧光和反射成像和光谱分析是否能够促进印度高危人群口腔肿瘤的早期发现和诊断。我们将确定多光谱成像和光谱学是否可以改善印度高危人群中潜在恶性口腔病变的筛查和诊断。我们将在印度孟买塔塔纪念医院招募190名口腔癌筛查试验受试者的光学数据与标准临床诊断、组织病理学结果和分子生物标记物发现进行比较。该项目的成功完成将决定这项多光谱成像和光谱技术在资源有限的社区中用于口腔癌检测和诊断的诊断潜力和适用性。