Precision Optical Guidance for Oral Biopsy Based on Next-Generation Hallmarks of Cancer
基于下一代癌症标志的口腔活检精密光学引导
基本信息
- 批准号:10565685
- 负责人:
- 金额:$ 63.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-25 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAlgorithmsAreaBackBenignBiopsyBlood VesselsCancer PatientCellsCollagenDevelopmentDiagnosisDiseaseDysplasiaEarly DiagnosisEarly treatmentEnsureEpitheliumExcisionFluorescenceFutureGenomic InstabilityGoalsHigh grade dysplasiaImageImaging technologyIncidenceInvadedLesionLeukoplakiaLightMalignant - descriptorMalignant NeoplasmsMapsMicroscopeMild DysplasiaModalityMolecularMorbidity - disease rateMorphologyMouth NeoplasmsMovementMucous MembraneMultimodal ImagingMutationNeoplasm MetastasisNeoplasmsNuclearOpticsOralOral DiagnosisOral mucous membrane structureOutcomePathologicPatient-Focused OutcomesPatientsPositioning AttributeProcessPrognosisPropertyResearchResolutionRiskScreening for Oral CancerSeveritiesSignal TransductionSiteSpecificityStage at DiagnosisSurfaceSurvival RateSystemTechnologyTimeTissuesWorkangiogenesiscostdensitydigitalfluorescence imagingglobal healthhigh resolution imaginghigh riskimage guidedimaging capabilitiesimaging modalityimaging probeimaging systemimprovedmalignant mouth neoplasmmortalitymouth squamous cell carcinomamultimodalityneoplasticnext generationnoveloptical imagingoral carcinogenesisoral cavity epitheliumoral dysplasiaoral lesionoral tissuepreventsurvival prediction
项目摘要
Project Summary/Abstract:
With over 300,000 new cases per year and a mortality rate of approximately 50%, oral cancer is a major global health
issue. The stage at diagnosis is the most important predictor of survival, and unfortunately, most patients are diagnosed
at a late stage. Oral cancer is preceded by visible mucosal changes which are designated oral potentially malignant
disorders (OPMD). Invasive biopsy of oral lesions is the gold standard to diagnose oral dysplasia and cancer, and
pathologic diagnosis of dysplasia is the best indicator of risk for oral cancer development. Dysplasia often arises in
patients with OPMDs; however, most practitioners lack expertise to distinguish OPMDs from benign lesions. It is difficult
even for experts to determine which oral lesions are at highest risk to contain dysplasia and should be biopsied. The goal
of this proposal is to develop and validate an Active Biopsy Guidance (ABG) optical imaging system, consisting of an
optical mapping scope and a high resolution microscope, to help clinicians determine precisely when and where to
biopsy suspicious oral lesions. The ABG system will integrate several optical imaging modalities to non-invasively probe
key molecular and morphologic changes associated with the next-generation hallmarks of cancer.
In Aim 1, we will develop a compact optical mapping scope that uses Digital Light Processing technology to capture
white light and auto-fluorescence images and actively project onto the oral mucosa a map highlighting areas at high risk
for oral dysplasia and cancer based on loss of collagen fluorescence (a signal of invasion and metastasis) and alterations
in epithelial NAD(P)H and FAD fluorescence (a signal of de-regulated cellular energetics). The mapping scope will
function as the first step in the image guidance sequence, projecting a visible map of high-risk regions on the oral tissue.
We will develop tracking algorithms to adjust the projected map to ensure accurate positioning despite patient
movement. In Aim 2, we will develop a low-cost fluorescence and reflectance high resolution microscope capable of
imaging nuclear morphology in the oral epithelium (a signal of sustained proliferative signaling, genome instability and
mutation) and microvascular density and morphology (a signal of angiogenesis). The high resolution probe will serve as a
confirmation modality to improve specificity. In Aim 3, we will integrate the optical mapping scope and high resolution
microscope into a single, compact Active Biopsy Guidance system and validate its ability to provide real-time precise
guidance for selection of oral biopsy sites in a study of high-risk patients undergoing surveillance for oral cancer.
Combining widefield autofluorescence imaging and high resolution imaging of nuclear and microvessel morphology will
provide a biologically directed approach to help clinicians precisely determine where and when to biopsy suspicious oral
lesions, achieving both high sensitivity and high specificity.
The impact of this research will be to provide interactive imaging technology that will enable earlier detection of oral
neoplasia and better patient outcomes addressing a long-standing, significant global health challenge.
项目总结/文摘:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ann M Gillenwater其他文献
Ann M Gillenwater的其他文献
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{{ truncateString('Ann M Gillenwater', 18)}}的其他基金
Deep learning microscope for slide-free and digital histology
用于无载玻片和数字组织学的深度学习显微镜
- 批准号:
10503039 - 财政年份:2022
- 资助金额:
$ 63.98万 - 项目类别:
Deep learning microscope for slide-free and digital histology
用于无载玻片和数字组织学的深度学习显微镜
- 批准号:
10664026 - 财政年份:2022
- 资助金额:
$ 63.98万 - 项目类别:
Mobile Imaging for Oral Cancer Screening Programs in Rural US Settings
美国农村地区口腔癌筛查项目的移动成像
- 批准号:
10396044 - 财政年份:2021
- 资助金额:
$ 63.98万 - 项目类别:
Mobile Imaging for Oral Cancer Screening Programs in Rural US Settings
美国农村地区口腔癌筛查项目的移动成像
- 批准号:
10193591 - 财政年份:2021
- 资助金额:
$ 63.98万 - 项目类别:
Precision Optical Guidance for Oral Biopsy Based on Next-Generation Hallmarks of Cancer
基于下一代癌症标志的口腔活检精密光学引导
- 批准号:
10326402 - 财政年份:2020
- 资助金额:
$ 63.98万 - 项目类别:
(PQC2) Optical Hallmarks of Aggressive Clones Within Oral Field Cancerization
(PQC2) 口腔癌化中侵袭性克隆的光学标志
- 批准号:
9319642 - 财政年份:2014
- 资助金额:
$ 63.98万 - 项目类别:
(PQC2) Optical Hallmarks of Aggressive Clones Within Oral Field Cancerization
(PQC2) 口腔癌化中侵袭性克隆的光学标志
- 批准号:
8912436 - 财政年份:2014
- 资助金额:
$ 63.98万 - 项目类别:
Oral Screening in India using Optical Imaging Technology
印度使用光学成像技术进行口腔筛查
- 批准号:
7290903 - 财政年份:2007
- 资助金额:
$ 63.98万 - 项目类别:
Oral Screening in India using Optical Imaging Technology
印度使用光学成像技术进行口腔筛查
- 批准号:
7463924 - 财政年份:2007
- 资助金额:
$ 63.98万 - 项目类别:
Oral Screening in India using Optical Imaging Technology
印度使用光学成像技术进行口腔筛查
- 批准号:
7615710 - 财政年份:2007
- 资助金额:
$ 63.98万 - 项目类别:
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