2007 Calcium Signaling Gordon Research Conference

描述（由申请人提供）：申请资金用于支付将于2007年7月8日至13日在美国新罕布什尔州蒂尔顿蒂尔顿学校举行的戈登钙信号研究会议的部分费用。钙是一种普遍存在的细胞内信使；它是许多细胞过程的重要调节因子，包括受精、细胞死亡、感觉转导、肌肉收缩、运动、胞吐和液体分泌。钙信号缺陷是多种疾病的一个特征，包括许多造成巨大社会经济负担的疾病（如高血压、免疫缺陷和中风）。会议每两年举行一次（与FASEB会议交替举行），在欧洲和美国交替举行。它为在钙信号传导的许多方面具有不同兴趣的科学家提供了首要论坛，以回顾这一活跃领域的令人兴奋的发展。该计划已被选中，包括那些在该领域最活跃的，而不重复最近的GRC或FASEB会议。会议规模小（限定140人，而且总是超额认购），强调互动讨论，确保了辩论的活跃。共有8个会议，选出了主持人以促进积极的讨论，并举行了一次全体演讲。海报是一个关键特征（大多数与会者出席）；每个会议主席将选择一张海报（共8张）作为演讲。整个项目的目标是建立钙信号蛋白的组装和组织与细胞钙稳态之间的连续性，以了解钙信号事件的分子基础，并了解这些过程如何在各种疾病中发挥作用。会议将致力于感觉和转导过程的组织以及膜受体，细胞内钙通道，钙进入机制，线粒体钙代谢，钙通道复合物的组装，以及钙在生理和疾病中的作用。这些主题具有根本的重要性，广泛的兴趣，并与许多疾病状态直接相关，包括神经退行性疾病和心血管疾病，衰老，癌症，感觉障碍和免疫疾病。钙是一种普遍存在的细胞内信使；它是许多细胞过程的重要调节因子，包括受精、细胞死亡、感觉转导、肌肉收缩、运动、胞吐和液体分泌。钙信号缺陷是多种疾病的一个特征，包括许多造成巨大社会经济负担的疾病（如高血压、免疫缺陷和中风）。因此，本次会议讨论的主题具有根本性的重要性、广泛的兴趣和与许多疾病状态直接相关，包括神经退行性疾病和心血管疾病、衰老、癌症、感觉障碍和免疫疾病。与会者将从最近和未发表的研究结果的介绍以及详细的讨论中受益。这些信息应该对正在进行的研究产生积极的影响。

DESCRIPTION (provided by applicant): Funds are requested to partially cover the costs of the Gordon Research Conference on Calcium Signaling to be held in Tilton School, Tilton, New Hampshire, USA, from 8-13 July, 2007. Calcium is a ubiquitous intracellular messenger; it is an essential regulator of many cellular processes including fertilization, cell death, sensory transduction, muscle contraction, motility, exocytosis and fluid secretion. Defective calcium signaling is a feature of diverse diseases, including many (e.g. hypertension, immunodeficiencies, and stroke) that are huge socioeconomic burdens. The conference takes place biennially (interleaved with the complementary FASEB meeting) and alternates between Europe and the USA. It provides the premier forum for scientists with diverse interests in the many facets of calcium signaling to review exciting developments in this active area. The program has been selected to include those most active in the field without replicating recent GRC or FASEB meetings. The small size of the meeting (limited to 140 and invariably over-subscribed) and emphasis on interactive discussion ensure lively debate. There are 8 sessions, with chairs selected to promote active discussion, and a plenary lecture. Posters are a key feature (most attendees present); they are presented each afternoon and each session chair will select a poster (8 in total) for presentation as a talk. Throughout the program the aim is to establish the continuity between the assembly and organization of calcium signaling proteins and cellular calcium homeostasis in order to understand the molecular basis of calcium signaling events as well as to understand how these processes can have a role in various diseases. Sessions will be devoted to the organization of sensory and transduction processes as well as membrane receptors, intracellular calcium channels, calcium entry mechanism, mitochondrial calcium metabolism, assembly of calcium channel complexes, and the role of calcium in physiology and disease. These topics are of fundamental importance, widespread interest and immediate relevance to many disease states including neurodegenerative and cardiovascular diseases, aging, cancer, sensory disorders, and immunological diseases. Calcium is a ubiquitous intracellular messenger; it is an essential regulator of many cellular processes including fertilization, cell death, sensory transduction, muscle contraction, motility, exocytosis and fluid secretion. Defective calcium signaling is a feature of diverse diseases, including many (e.g. hypertension, immunodeficiencies, and stroke) that are huge socioeconomic burdens. Thus the topics addressed in this conference are of fundamental importance, widespread interest and immediate relevance to many disease states including neurodegenerative and cardiovascular diseases, aging, cancer, sensory disorders, and immunological diseases. Participants will benefit from presentation of recent and unpublished findings as well as from the detailed discussions. This information should have a positive impact on ongoing research.