2007 Calcium Signaling Gordon Research Conference

2007 年钙信号戈登研究会议

• 批准号: 7270909
• 负责人: Alexei Tepikin
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-26 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7270909
• 关键词: Address; Aging; Area; Calcium; Calcium Channel; Calcium Signaling; Cardiovascular Diseases; Cell Death; Cell physiology; Complex; Development; Disease; Ensure; Europe; Event; Exocytosis; Fertilization; Fluids and Secretions; Funding Applicant; Homeostasis; Hypertension; Immune System Diseases; Immunologic Deficiency Syndromes; Malignant Neoplasms; Membrane; Mitochondria; Molecular; Muscle Contraction; Nerve Degeneration; New Hampshire; Participant; Physiology; Process; Research; Role; Schools; Scientist; Sensory; Sensory Disorders; Signaling Protein; Stroke; base; calcium metabolism; cell motility; cost; interest; lectures; posters; programs; receptor; size; socioeconomics; symposium

DESCRIPTION (provided by applicant): Funds are requested to partially cover the costs of the Gordon Research Conference on Calcium Signaling to be held in Tilton School, Tilton, New Hampshire, USA, from 8-13 July, 2007. Calcium is a ubiquitous intracellular messenger; it is an essential regulator of many cellular processes including fertilization, cell death, sensory transduction, muscle contraction, motility, exocytosis and fluid secretion. Defective calcium signaling is a feature of diverse diseases, including many (e.g. hypertension, immunodeficiencies, and stroke) that are huge socioeconomic burdens. The conference takes place biennially (interleaved with the complementary FASEB meeting) and alternates between Europe and the USA. It provides the premier forum for scientists with diverse interests in the many facets of calcium signaling to review exciting developments in this active area. The program has been selected to include those most active in the field without replicating recent GRC or FASEB meetings. The small size of the meeting (limited to 140 and invariably over-subscribed) and emphasis on interactive discussion ensure lively debate. There are 8 sessions, with chairs selected to promote active discussion, and a plenary lecture. Posters are a key feature (most attendees present); they are presented each afternoon and each session chair will select a poster (8 in total) for presentation as a talk. Throughout the program the aim is to establish the continuity between the assembly and organization of calcium signaling proteins and cellular calcium homeostasis in order to understand the molecular basis of calcium signaling events as well as to understand how these processes can have a role in various diseases. Sessions will be devoted to the organization of sensory and transduction processes as well as membrane receptors, intracellular calcium channels, calcium entry mechanism, mitochondrial calcium metabolism, assembly of calcium channel complexes, and the role of calcium in physiology and disease. These topics are of fundamental importance, widespread interest and immediate relevance to many disease states including neurodegenerative and cardiovascular diseases, aging, cancer, sensory disorders, and immunological diseases. Calcium is a ubiquitous intracellular messenger; it is an essential regulator of many cellular processes including fertilization, cell death, sensory transduction, muscle contraction, motility, exocytosis and fluid secretion. Defective calcium signaling is a feature of diverse diseases, including many (e.g. hypertension, immunodeficiencies, and stroke) that are huge socioeconomic burdens. Thus the topics addressed in this conference are of fundamental importance, widespread interest and immediate relevance to many disease states including neurodegenerative and cardiovascular diseases, aging, cancer, sensory disorders, and immunological diseases. Participants will benefit from presentation of recent and unpublished findings as well as from the detailed discussions. This information should have a positive impact on ongoing research.

描述（由申请人提供）：申请资金用于支付将于2007年7月8日至13日在美国新罕布什尔州蒂尔顿的蒂尔顿学校举行的戈登钙信号研究会议的部分费用。钙是一种普遍存在的细胞内信使;它是许多细胞过程的重要调节剂，包括受精、细胞死亡、感觉转导、肌肉收缩、运动、胞吐和液体分泌。钙信号传导缺陷是多种疾病的一个特征，包括许多造成巨大社会经济负担的疾病（如高血压、免疫缺陷和中风）。会议每两年举行一次（与补充FASEB会议交错），并在欧洲和美国之间交替举行。它为在钙信号的许多方面具有不同兴趣的科学家提供了首要论坛，以回顾这一活跃领域令人兴奋的发展。该方案已被选定，以包括那些最活跃的领域，而不复制最近的GRC或FASEB会议。会议规模小（限于140人，而且总是超额报名），强调互动式讨论，确保了辩论的活跃。有8个会议，与椅子选择，以促进积极的讨论，和一个全体讲座。海报是一个关键特征（大多数与会者出席）;他们每天下午都会展示，每个会议主席将选择一张海报（共8张）作为演讲。在整个计划中，目的是建立钙信号蛋白和细胞钙稳态的组装和组织之间的连续性，以了解钙信号事件的分子基础，以及了解这些过程如何在各种疾病中发挥作用。课程将致力于感觉和传导过程的组织以及膜受体、细胞内钙通道、钙进入机制、线粒体钙代谢、钙通道复合物的组装以及钙在生理和疾病中的作用。这些主题具有根本的重要性，广泛的兴趣和直接相关的许多疾病状态，包括神经退行性疾病和心血管疾病，衰老，癌症，感觉障碍和免疫性疾病。钙是一种普遍存在的细胞内信使;它是许多细胞过程的重要调节剂，包括受精、细胞死亡、感觉转导、肌肉收缩、运动、胞吐和液体分泌。钙信号传导缺陷是多种疾病的一个特征，包括许多造成巨大社会经济负担的疾病（如高血压、免疫缺陷和中风）。因此，本次会议讨论的主题具有根本的重要性，广泛的兴趣和直接相关的许多疾病状态，包括神经退行性疾病和心血管疾病，衰老，癌症，感觉障碍和免疫性疾病。与会者将受益于最近和未发表的调查结果的介绍以及详细的讨论。这些信息应该对正在进行的研究产生积极影响。