4th International Conference on Children's Bone Health

描述（由申请人提供）：2000年，NIH骨质疏松症预防、诊断和治疗共识发展会议将儿童时期的骨累积确定为“可能是终身骨骼健康的最重要决定因素”。2004年外科医生关于骨骼健康和骨质疏松症的报告重申了最佳峰值骨量对终身骨骼健康的重要性，以及遗传异常、营养缺乏、慢性疾病和缺乏锻炼对生长期间骨骼增长的潜在负面影响。重要的是，外科医生报告和NIH共识声明都呼吁研究确定最大限度地提高儿童骨骼健康的策略，解决慢性疾病对骨骼增长的影响，并确定骨骼治疗对骨骼生长的影响。近年来，随着遗传学、骨免疫学、骨生物力学、骨分化和发育中的分子信号和核受体研究的显著进展，骨转化研究急剧增加。第四届儿童骨骼健康国际会议（ICCBH 4）将于2007年6月在加拿大蒙特利尔举行。ICCBH 4会议的目标是：（1）审查与骨骼发育和儿童骨骼健康相关的基础、转化和临床研究的最新进展，（2）让学员和初级教师向国际观众介绍他们的工作，以及（3）让与会者就国际临床密度测定学会的证据提供实质性的投入和公众意见-基于儿童骨密度评估指南。科学计划委员会制定了一个计划，包括最先进的演示，研讨会和会议继发性骨质疏松症，营养，遗传学，骨折流行病学，骨活检和儿童新骨疗法。这项R13提案寻求资金，以支持20名受训人员和初级调查员的差旅费。该奖项的获奖者将根据其提交给ICCBH 4评审小组的第一作者摘要的质量以及他们的研究导师的支持信进行选择，以验证他们的培训/初级教师身份。ICCBH 4获奖者参加会议将促进他们作为与儿童骨骼健康相关的基础，翻译和临床研究的独立研究者的发展，并将促进这一快速发展的医学领域的跨学科和合作研究。2004年外科医生关于骨骼健康的报告将儿童时期的骨骼增长确定为终身骨骼健康的关键决定因素，并呼吁进行研究以最大限度地提高儿童的骨骼增长。该提案要求提供资金，以支持20名受训人员和初级研究人员参加第四届儿童骨骼健康国际会议的差旅费;这一支持将促进他们在与儿童骨骼健康有关的基础、翻译和临床研究中作为独立研究人员的发展。

DESCRIPTION (provided by applicant): In 2000, the NIH Osteoporosis Prevention, Diagnosis, and Therapy Consensus Development Conference identified bone accrual during childhood as "perhaps the most important determinant of life-long skeletal health". The 2004 Surgeon General's Report on Bone Health and Osteoporosis reiterated the importance of optimal peak bone mass for lifelong skeletal health, as well as the potential negative effects of genetic abnormalities, nutritional deficiencies, chronic disease, and lack of exercise on bone accrual during growth. Importantly, both the Surgeon General's Report and the NIH Consensus Statement called for research to identify strategies to maximize bone health in children, to address the impact of chronic diseases on bone accrual, and to determine the effects of bone therapies on the growing skeleton. In recent years, there have been dramatic increases in translational bone research with significant advances in genetics, osteoimmunology, bone biomechanics, and studies of molecular signaling and nuclear receptors in bone differentiation and development. The 4th International Conference on Children's Bone Health (ICCBH4) will take place in June 2007 in Montreal, Canada. The objectives of the ICCBH4 meeting are (1) to examine the latest advances in basic, translational and clinical research relating to bone development and children's bone health, (2) to allow trainees and junior faculty to present their work to an international audience, and (3) to have attendees provide substantial input and public comment on the International Society for Clinical Densitometry evidence-based guidelines for the assessment of bone density in children. The Scientific Program Committee has developed a program that includes state-of-art presentations, workshops, and sessions on secondary osteoporosis, nutrition, genetics, fracture epidemiology, bone biopsies, and novel bone therapies in children. This R13 proposal seeks funding to support travel expenses for 20 trainees and junior investigators. Recipients for this award will be selected based on the quality of their first-author abstracts submitted to the ICCBH4 review panel, as well as a letter of support from their research mentor, verifying their training / junior faculty status. Participation in the meeting by ICCBH4 award recipients will promote their development as independent investigators in basic, translation and clinical research related to bone health in children, and will foster interdisciplinary and collaborative research in this rapidly evolving field of medicine. The 2004 Surgeon General's Report on Bone Health identified bone accrual during childhood as a critical determinant of lifelong skeletal health and called for research to maximize bone accrual in children. This proposal requests funds to support travel expenses for 20 trainees and junior investigators to attend the 4th International Conference on Children's Bone Health; this support will promote their development as independent investigators in basic, translation and clinical research related to bone health in children.