4th International Conference on Children's Bone Health

描述（由申请人提供）：2000年，美国国立卫生研究院骨质疏松症预防、诊断和治疗共识发展会议将儿童时期的骨质积累确定为“可能是终身骨骼健康最重要的决定因素”。2004年卫生局局长关于骨骼健康和骨质疏松症的报告重申了最佳峰值骨量对终身骨骼健康的重要性，以及遗传异常、营养缺乏、慢性疾病和缺乏运动对生长过程中骨骼累积的潜在负面影响。重要的是，卫生局局长的报告和美国国立卫生研究院的共识声明都呼吁进行研究，以确定最大化儿童骨骼健康的策略，解决慢性疾病对骨骼累积的影响，并确定骨骼治疗对骨骼生长的影响。近年来，转译骨的研究急剧增加，在遗传学、骨免疫学、骨生物力学、骨分化发育中的分子信号和核受体研究等方面取得了重大进展。第四届儿童骨骼健康国际会议（ICCBH4）将于2007年6月在加拿大蒙特利尔举行。ICCBH4会议的目标是(1)研究与骨骼发育和儿童骨骼健康相关的基础、转化和临床研究的最新进展，(2)允许学员和初级教师向国际观众展示他们的工作，(3)让与会者对国际临床密度测量学会基于证据的儿童骨密度评估指南提供大量的投入和公众评论。科学计划委员会已经制定了一项计划，包括最新的报告，研讨会，以及关于继发性骨质疏松症，营养，遗传学，骨折流行病学，骨活检和儿童新骨疗法的会议。这项R13提案寻求资助20名受训人员和初级调查人员的旅费。该奖项的获奖者将根据他们提交给ICCBH4评审小组的第一作者摘要的质量，以及他们的研究导师的支持信，证明他们的培训/初级教师身份。ICCBH4获奖者参加会议将促进他们在儿童骨骼健康相关的基础、翻译和临床研究方面的独立研究者的发展，并将促进这一快速发展的医学领域的跨学科和合作研究。2004年卫生局局长关于骨骼健康的报告指出，儿童时期的骨骼积累是终生骨骼健康的关键决定因素，并呼吁研究如何最大限度地提高儿童的骨骼积累。本提案要求经费用于支持20名受训人员和初级调查员参加第四届国际儿童骨骼健康会议的旅费；这种支持将促进他们发展成为与儿童骨骼健康有关的基础、转化和临床研究的独立研究者。

DESCRIPTION (provided by applicant): In 2000, the NIH Osteoporosis Prevention, Diagnosis, and Therapy Consensus Development Conference identified bone accrual during childhood as "perhaps the most important determinant of life-long skeletal health". The 2004 Surgeon General's Report on Bone Health and Osteoporosis reiterated the importance of optimal peak bone mass for lifelong skeletal health, as well as the potential negative effects of genetic abnormalities, nutritional deficiencies, chronic disease, and lack of exercise on bone accrual during growth. Importantly, both the Surgeon General's Report and the NIH Consensus Statement called for research to identify strategies to maximize bone health in children, to address the impact of chronic diseases on bone accrual, and to determine the effects of bone therapies on the growing skeleton. In recent years, there have been dramatic increases in translational bone research with significant advances in genetics, osteoimmunology, bone biomechanics, and studies of molecular signaling and nuclear receptors in bone differentiation and development. The 4th International Conference on Children's Bone Health (ICCBH4) will take place in June 2007 in Montreal, Canada. The objectives of the ICCBH4 meeting are (1) to examine the latest advances in basic, translational and clinical research relating to bone development and children's bone health, (2) to allow trainees and junior faculty to present their work to an international audience, and (3) to have attendees provide substantial input and public comment on the International Society for Clinical Densitometry evidence-based guidelines for the assessment of bone density in children. The Scientific Program Committee has developed a program that includes state-of-art presentations, workshops, and sessions on secondary osteoporosis, nutrition, genetics, fracture epidemiology, bone biopsies, and novel bone therapies in children. This R13 proposal seeks funding to support travel expenses for 20 trainees and junior investigators. Recipients for this award will be selected based on the quality of their first-author abstracts submitted to the ICCBH4 review panel, as well as a letter of support from their research mentor, verifying their training / junior faculty status. Participation in the meeting by ICCBH4 award recipients will promote their development as independent investigators in basic, translation and clinical research related to bone health in children, and will foster interdisciplinary and collaborative research in this rapidly evolving field of medicine. The 2004 Surgeon General's Report on Bone Health identified bone accrual during childhood as a critical determinant of lifelong skeletal health and called for research to maximize bone accrual in children. This proposal requests funds to support travel expenses for 20 trainees and junior investigators to attend the 4th International Conference on Children's Bone Health; this support will promote their development as independent investigators in basic, translation and clinical research related to bone health in children.